2015
Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania
Liu E, McCree R, Mtisi E, Fawzi WW, Aris E, Lema IA, Hertzmark E, Chalamilla G, Li N, Vermund SH, Spiegelman D. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania. International Journal Of STD & AIDS 2015, 27: 219-225. PMID: 25957324, PMCID: PMC11340030, DOI: 10.1177/0956462415584466.Peer-Reviewed Original ResearchConceptsCervical squamous intraepithelial lesionsSquamous intraepithelial lesionsHIV disease stageCell countIntraepithelial lesionsDisease stageHigh-grade squamous intraepithelial lesionsAdvanced HIV disease stageCervical cancer prevention servicesLow CD4 cell countsCD4 cell countCancer prevention servicesCross-sectional studyResource-limited settingsCervical inflammationLow CD4Median CD4HIV careMedian ageCervical screeningPapanicolaou smearsRisk factorsTreatment clinicsPrevention servicesHIV
2014
Assessment of High-Risk Human Papillomavirus Infections Using Clinician- and Self-Collected Cervical Sampling Methods in Rural Women from Far Western Nepal
Johnson DC, Bhatta MP, Smith JS, Kempf MC, Broker TR, Vermund SH, Chamot E, Aryal S, Lhaki P, Shrestha S. Assessment of High-Risk Human Papillomavirus Infections Using Clinician- and Self-Collected Cervical Sampling Methods in Rural Women from Far Western Nepal. PLOS ONE 2014, 9: e101255. PMID: 24978811, PMCID: PMC4076302, DOI: 10.1371/journal.pone.0101255.Peer-Reviewed Original ResearchConceptsHigh-grade squamous intraepithelial lesionsRural Nepali womenHR-HPVSquamous cell carcinomaHuman papillomavirusHigh-risk human papillomavirus infectionHigh cervical cancer ratesOverall HR-HPV prevalenceSelf-collected cervical samplesHigh-risk HPV typesGrade squamous intraepithelial lesionNepali womenClinician-collected samplesHR-HPV mRNAHR-HPV prevalenceSelf-collected testsCervical cancer ratesHuman papillomavirus infectionSelf-collected samplesSquamous intraepithelial lesionsAuxiliary nurse midwivesPre-cancer lesionsCervico-vaginal specimensSelf-collection methodType-specific distribution
2012
Cervical Cancer Prevention in Low- and Middle-Income Countries: Feasible, Affordable, Essential
Sahasrabuddhe VV, Parham GP, Mwanahamuntu MH, Vermund SH. Cervical Cancer Prevention in Low- and Middle-Income Countries: Feasible, Affordable, Essential. Cancer Prevention Research 2012, 5: 11-17. PMID: 22158053, PMCID: PMC3586242, DOI: 10.1158/1940-6207.capr-11-0540.Peer-Reviewed Original ResearchConceptsCervical cancer preventionHuman immunodeficiency virusCervical cancerMiddle-income countriesCancer preventionPrevention servicesCervical cancer prevention servicesCancer prevention servicesCervical cancer screeningGynecologic issuesImmunodeficiency virusHuman papillomavirusCancer screeningEarly treatmentPelvic examHigh-income countriesWorldwide burdenCare deliveryNew casesScreening testHPVCancerLMICsEffective alternativePrevention
2011
Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India
Sahasrabuddhe VV, Bhosale RA, Kavatkar AN, Nagwanshi CA, Joshi SN, Jenkins CA, Shepherd BE, Kelkar RS, Sahay S, Risbud AR, Vermund SH, Mehendale SM. Comparison of visual inspection with acetic acid and cervical cytology to detect high‐grade cervical neoplasia among HIV‐infected women in India. International Journal Of Cancer 2011, 130: 234-240. PMID: 21387289, PMCID: PMC3516675, DOI: 10.1002/ijc.25971.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAdultCervix UteriColposcopyCross-Sectional StudiesCytodiagnosisDNA, ViralFemaleHIVHIV InfectionsHumansIndiaMass ScreeningPapanicolaou TestPolymerase Chain ReactionPredictive Value of TestsSensitivity and SpecificityUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsCervical cytologyHigh-grade squamous intraepithelial lesionsHigh-grade cervical neoplasiaNegative predictive value estimatesScreening testHPV-positive CIN2Atypical squamous cellsSquamous intraepithelial lesionsHuman immunodeficiency virusConventional cervical cytologyPredictive value estimatesSecondary prevention methodsNonpregnant HIVRigorous endpointsAntiretroviral therapyHIV/Intraepithelial lesionsCervical neoplasiaCervical cancerImmunodeficiency virusSquamous cellsHuman papillomavirusUndetermined significanceIntraepithelial cellsCare program
2006
Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia
Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Shepherd BE, Hicks ML, Stringer EM, Vermund SH. Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia. Gynecologic Oncology 2006, 103: 1017-1022. PMID: 16875716, PMCID: PMC2748907, DOI: 10.1016/j.ygyno.2006.06.015.Peer-Reviewed Original ResearchConceptsHigh-risk HPV typesSquamous intraepithelial lesionsSquamous cell carcinomaHPV typesIntraepithelial lesionsHIV/AIDS care servicesPrevalence of SILHigh-grade squamous intraepithelial lesionsLow-grade squamous intraepithelial lesionsCervical squamous intraepithelial lesionsMultivariable logistic regression modelingNon-pregnant HIVScreening of HIVDevelopment of HPVLogistic regression modelingResource-constrained settingsResource-constrained nationsMedian CD4Abnormal cytologyAntiretroviral therapyCytological lesionsHPV typingIndependent predictorsMedian ageCervical cancer
2003
Utility of cervicography in HIV-infected and uninfected adolescents
Moscicki AB, Durako SJ, Ma Y, Darragh T, Vermund SH. Utility of cervicography in HIV-infected and uninfected adolescents. Journal Of Adolescent Health 2003, 32: 204-213. PMID: 12606114, DOI: 10.1016/s1054-139x(02)00461-5.Peer-Reviewed Original ResearchConceptsPositive predictive valuePap smearUninfected groupHigh-risk adolescent populationAdequate Pap smearsLow positive predictive valueRepeat Papanicolaou smearsSingle Pap smearVisit 6 monthsHIV-positive youthHIV-negative youthPositive cervigramHIV infectionCervical cancerProspective studyVisit 1Papanicolaou smearsUninfected adolescentsHIVPredictive valueTime of analysisAdolescent populationCervicography
2001
Viral latency--the papillomavirus model.
Broker TR, Jin G, Croom-Rivers A, Bragg SM, Richardson M, Chow LT, Vermund SH, Alvarez RD, Pappas PG, Squires KE, Hoesley CJ. Viral latency--the papillomavirus model. 2001, 106: 443-51; discussion 452-3, 465-75. PMID: 11761260.Peer-Reviewed Original ResearchConceptsHPV typesHPV DNAAIDS cohortEnd-stage renal failureCervico-vaginal lavageKidney transplantation candidatesConsequence of immunosuppressionHuman papillomavirus infectionLower genital tractDifferent HPV typesLatent viral infectionFunctional immune systemHIV/AIDSSub-clinical stateHPV prevalenceHIV cohortHPV infectionKidney transplantationNested polymerase chain reaction amplificationPapillomavirus infectionRenal failureTransplantation candidatesHPV 6Immune depressionImmunosuppressive conditions
1994
Risk Factors For Squamous Intraepithelial Lesions On Pap Smear In Women At Risk For Human Immunodeficiency Virus Infection
Klein R, Ho G, Vermund S, Fleming I, Burk R. Risk Factors For Squamous Intraepithelial Lesions On Pap Smear In Women At Risk For Human Immunodeficiency Virus Infection. The Journal Of Infectious Diseases 1994, 170: 1404-1409. PMID: 7995978, DOI: 10.1093/infdis/170.6.1404.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Squamous CellCD4 Lymphocyte CountDNA, ViralFemaleHIV AntibodiesHIV InfectionsHumansImmunocompromised HostMiddle AgedMultivariate AnalysisNew YorkOdds RatioPapanicolaou TestPapillomaviridaePapillomavirus InfectionsPrevalenceRisk FactorsTumor Virus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginal SmearsConceptsSquamous intraepithelial lesionsHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionRisk factorsHPV infectionHIV infectionIntraepithelial lesionsPap smearVirus infectionHigh-risk HPV typesGenital HPV infectionHIV antibody testingIndependent risk factorSevere HIVSevere immunosuppressionHPV typesAntibody testingGenital HPVUnivariate analysisMultivariate analysisInfectionGenome detectionImmunosuppressionRiskLesions
1993
Chlamydial cervical infection in jailed women.
Holmes MD, Safyer SM, Bickell NA, Vermund SH, Hanff PA, Phillips RS. Chlamydial cervical infection in jailed women. American Journal Of Public Health 1993, 83: 551-5. PMID: 8460733, PMCID: PMC1694480, DOI: 10.2105/ajph.83.4.551.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceChlamydia InfectionsChlamydia trachomatisComorbidityCondomsEducational StatusFemaleHealth PolicyHumansInterviews as TopicMarital StatusMass ScreeningMultivariate AnalysisNew York CityPrevalencePrisonersRacial GroupsRisk FactorsSensitivity and SpecificityUterine Cervical DiseasesVaginal SmearsConceptsChlamydial infectionCervical infectionInfected womenC trachomatisRisk factorsChlamydia trachomatis cervical infectionChlamydial cervical infectionMucopurulent cervical dischargeIndependent risk factorC trachomatis infectionNew York City jailsPelvic tendernessCervical dischargePresumptive treatmentCervical culturesTrachomatis infectionPresumptive therapyPositive culturesAdult womenInfectionWomenPrevalenceTrachomatisCity jailsTreatment
1992
Genital Human Papillomavirus Infection in Women
Kelley K, Galbraith M, Vermund S. Genital Human Papillomavirus Infection in Women. Journal Of Obstetric Gynecologic & Neonatal Nursing 1992, 21: 503-515. PMID: 1337355, DOI: 10.1111/j.1552-6909.1992.tb01771.x.Peer-Reviewed Original ResearchConceptsGenital human papillomavirus (HPV) infectionHuman papillomavirus infectionHuman papillomavirusCervical neoplasiaHPV infectionPapillomavirus infectionHIV infectionPapanicolaou testRisk factorsPrevalence of HPVCervical intraepithelial lesionsPutative precursor lesionsOutcome of therapyEffective screening toolAbnormal cervical cellsHPV typesIntraepithelial lesionsCervical cancerCondylomata acuminataPrecursor lesionsClinicians' knowledgeNeoplasiaInfectionLiterature searchYoung women
1991
Human papillomavirus, gonorrhea, syphilis, and cervical dysplasia in jailed women.
Bickell NA, Vermund SH, Holmes M, Safyer S, Burk RD. Human papillomavirus, gonorrhea, syphilis, and cervical dysplasia in jailed women. American Journal Of Public Health 1991, 81: 1318-20. PMID: 1928533, PMCID: PMC1405301, DOI: 10.2105/ajph.81.10.1318.Peer-Reviewed Original ResearchConceptsHuman papillomavirusPap smearRoutine intake proceduresAbnormal Pap smearsBehavioral risk factorsNew York City jailsCervicovaginal lavageSerologic syphilisHPV infectionCervical diseaseCervical dysplasiaCervical cytologyRisk factorsIntake proceduresFemale detaineesWomenPapillomavirusSyphilisHigh rateCity jailsDiseaseSmearsIncarcerated womenLavageGonorrheaPlasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia.
Basu J, Palan PR, Vermund SH, Goldberg GL, Burk RD, Romney SL. Plasma ascorbic acid and beta-carotene levels in women evaluated for HPV infection, smoking, and cervix dysplasia. Cancer Epidemiology 1991, 15: 165-70. PMID: 1647869.Peer-Reviewed Original ResearchConceptsBeta-carotene levelsHPV infectionCervical dysplasiaClinical statusPap smearPeripheral venous blood samplesImportance of smokingRepeat Pap smearHuman papillomavirus infectionAbnormal Pap smearsVenous blood samplesGrades of severityPlasma ascorbic acidAscorbic acid levelsCervix dysplasiaColposcopy clinicHPV statusPapillomavirus infectionLavage specimenPlasma levelsMean plasmaDysplastic groupBlood samplesDysplasiaSmoking
1989
High Prevalence Rate of Human Papillomavirus Infection and Association With Abnormal Papanicolaou Smears in Sexually Active Adolescents
Rosenfeld WD, Vermund SH, Wentz SJ, Burk RD. High Prevalence Rate of Human Papillomavirus Infection and Association With Abnormal Papanicolaou Smears in Sexually Active Adolescents. JAMA Pediatrics 1989, 143: 1443-1447. PMID: 2556023, DOI: 10.1001/archpedi.1989.02150240065018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleHumansPapanicolaou TestPapillomaviridaeRisk FactorsSexTumor Virus InfectionsVaginal SmearsConceptsAbnormal Papanicolaou smearsHuman papillomavirusHPV infectionHPV DNACytologic abnormalitiesPapanicolaou smearsPrevalence ratesLow-grade cervical intraepithelial neoplasiaRoutine cervical cytologic screeningMultiple lifetime sexual partnersHuman papillomavirus infectionCervical intraepithelial neoplasiaHPV types 6/11Cervical epithelial abnormalitiesCervical cytologic screeningHigh prevalence ratesYears of ageLifetime sexual partnersCervicovaginal lavageHPV presentUninfected patientsPapillomavirus infectionCervical neoplasiaCytologic screeningIntraepithelial neoplasiaComparison of Cytobrush and cervicovaginal lavage sampling methods for the detection of genital human papillomavirus
Goldberg G, Vermund S, Schiffman M, Ritter D, Spitzer C, Burk R. Comparison of Cytobrush and cervicovaginal lavage sampling methods for the detection of genital human papillomavirus. American Journal Of Obstetrics And Gynecology 1989, 161: 1669-1672. PMID: 2557764, DOI: 10.1016/0002-9378(89)90947-2.Peer-Reviewed Original ResearchConceptsHuman papillomavirus deoxyribonucleic acidCervicovaginal lavageHuman papillomavirusGenital human papillomavirusFemale lower genital tractNoninvasive methodHuman papillomavirus infectionLower genital tractSensitive noninvasive methodExfoliated cervical cellsComparison of cytobrushSubstantial clinical importanceColposcopy clinicPapillomavirus infectionCervical neoplasiaGenital tractLavagePapillomavirusClinical importanceEtiologic agentCervical cellsPatientsDeoxyribonucleic acidSouthern blot hybridizationCells
1988
Detection of human papillomavirus deoxyribonucleic acid in exfoliated cervicovaginal cells as a predictor of cervical neoplasia in a high-risk population
Ritter D, Kadish A, Vermund S, Romney S, Villari D, Burk R. Detection of human papillomavirus deoxyribonucleic acid in exfoliated cervicovaginal cells as a predictor of cervical neoplasia in a high-risk population. American Journal Of Obstetrics And Gynecology 1988, 159: 1517-1525. PMID: 2849881, DOI: 10.1016/0002-9378(88)90587-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBiopsyCarcinoma, Squamous CellCervix UteriDNA, ViralFemaleForecastingHumansMiddle AgedPapanicolaou TestPapillomaviridaeRisk FactorsSensitivity and SpecificityTherapeutic IrrigationTumor Virus InfectionsUterine Cervical DiseasesUterine Cervical NeoplasmsVaginaVaginal SmearsConceptsHuman papillomavirus detectionHuman papillomavirus deoxyribonucleic acidHuman papillomavirus typesHuman papillomavirus type 16Cervical lesionsHuman papillomavirusPapillomavirus detectionPapillomavirus type 16Cervicovaginal lavageCytologic examinationPapillomavirus typesType 16Older womenHuman papillomavirus-negative womenPositive findingsCancerous lesionsAbnormal cytologic findingsHospital colposcopy clinicHuman papillomavirus infectionHigh-risk populationNegative cytologic resultsYears of ageHuman papillomavirus type 18Colposcopy clinicPapillomavirus infection