2016
High HIV prevalence and the internet as a source of HIV-related service information at a community-based organization in Peru: a cross-sectional study of men who have sex with men
Passaro RC, Haley CA, Sanchez H, Vermund SH, Kipp AM. High HIV prevalence and the internet as a source of HIV-related service information at a community-based organization in Peru: a cross-sectional study of men who have sex with men. BMC Public Health 2016, 16: 871. PMID: 27557857, PMCID: PMC4997688, DOI: 10.1186/s12889-016-3561-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultCommunity Health ServicesCross-Sectional StudiesHIV InfectionsHomosexuality, MaleHumansInformation Seeking BehaviorInformation ServicesInternetLogistic ModelsMaleMarketing of Health ServicesOdds RatioPatient Acceptance of Health CarePeer GroupPeruPrevalenceRisk-TakingSex WorkersSexual BehaviorSexual PartnersYoung AdultConceptsHIV prevalenceHIV servicesCross-sectional studyHIV careCommunity-based organizationsMethodsA cross-sectional studyMultivariable logistic regression modelSource of HIVHigh-risk personsSex workersHigh HIV prevalenceGeneral adult populationSex workers groupSexual risk behaviorsResource-limited settingsLogistic regression modelsHIV diagnosisWorker groupsHigh riskAdult populationInfected individualsPerson groupRisk behaviorsRisk profileMSMRisk Factors for Loss to Follow-Up among People Who Inject Drugs in a Risk Reduction Program at Karachi, Pakistan. A Case-Cohort Study
Samo RN, Agha A, Shah SA, Altaf A, Memon A, Blevins M, Qian HZ, Vermund SH. Risk Factors for Loss to Follow-Up among People Who Inject Drugs in a Risk Reduction Program at Karachi, Pakistan. A Case-Cohort Study. PLOS ONE 2016, 11: e0147912. PMID: 26840414, PMCID: PMC4739707, DOI: 10.1371/journal.pone.0147912.Peer-Reviewed Original ResearchConceptsCase-cohort studyMale PWIDHarm reduction programsRisk reduction programsRisk factorsReduction programsNeedle/syringe exchangeProspective cohort studyMultivariable logistic regressionResource-limited settingsHistory of incarcerationCohort studyMedian ageIncidence rateSyringe exchangePWIDMale peopleYounger ageLogistic regressionYoung menMonthsKarachiMenActive outreachProgrammatic challenges
2015
Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline
Brentlinger PE, Silva WP, Vermund SH, Valverde E, Buene M, Moon TD. Practical Management of HIV-Associated Anemia in Resource-Limited Settings: Prospective Observational Evaluation of a New Mozambican Guideline. AIDS Research And Human Retroviruses 2015, 32: 12-25. PMID: 26178574, PMCID: PMC4692124, DOI: 10.1089/aid.2015.0030.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAnthelminticsAnti-HIV AgentsAntimalarialsAntitubercular AgentsCD4 Lymphocyte CountCoinfectionDeveloping CountriesDisease ManagementFemaleHelminthiasisHemoglobinsHIV InfectionsHumansLost to Follow-UpMalaria, FalciparumMaleMozambiquePractice Guidelines as TopicProspective StudiesRural PopulationTuberculosis, PulmonaryConceptsHIV-associated anemiaAdverse drug reactionsDrug reactionsHemoglobin responseGuideline revisionsIron deficiencyLower body mass indexCo-trimoxazole prophylaxisDiscontinuation of zidovudineLaboratory-confirmed malariaProspective observational evaluationRural Zambézia ProvinceT-cell countsT-lymphocyte countsSmear-positive tuberculosisBody mass indexResource limited settingsResource-limited settingsLogistic regression modelsAnaemic HIVStudy cliniciansAntiretroviral therapyEsophageal candidiasisPresumptive treatmentAnemia managementPrevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania
Liu E, McCree R, Mtisi E, Fawzi WW, Aris E, Lema IA, Hertzmark E, Chalamilla G, Li N, Vermund SH, Spiegelman D. Prevalence and risk factors of cervical squamous intraepithelial lesions among HIV-infected women in Dar es Salaam, Tanzania. International Journal Of STD & AIDS 2015, 27: 219-225. PMID: 25957324, DOI: 10.1177/0956462415584466.Peer-Reviewed Original ResearchConceptsCervical squamous intraepithelial lesionsSquamous intraepithelial lesionsHIV disease stageCell countIntraepithelial lesionsDisease stageHigh-grade squamous intraepithelial lesionsAdvanced HIV disease stageCervical cancer prevention servicesLow CD4 cell countsCD4 cell countCancer prevention servicesCross-sectional studyResource-limited settingsCervical inflammationLow CD4Median CD4HIV careMedian ageCervical screeningPapanicolaou smearsRisk factorsTreatment clinicsPrevention servicesHIV
2014
Poor Clinical Outcomes for HIV Infected Children on Antiretroviral Therapy in Rural Mozambique: Need for Program Quality Improvement and Community Engagement
Vermund SH, Blevins M, Moon TD, José E, Moiane L, Tique JA, Sidat M, Ciampa PJ, Shepherd BE, Vaz LM. Poor Clinical Outcomes for HIV Infected Children on Antiretroviral Therapy in Rural Mozambique: Need for Program Quality Improvement and Community Engagement. PLOS ONE 2014, 9: e110116. PMID: 25330113, PMCID: PMC4203761, DOI: 10.1371/journal.pone.0110116.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyAntiretroviral therapyInfant diagnosisClinical outcomesEarly infant diagnosisPoor clinical outcomeYears of ageResource-limited settingsUnknown clinical outcomesCohort mortality ratesQuality improvement effortsART initiationCART initiationRural MozambiqueHIV servicesAdults 15HIV prevalenceKaplan-MeierHigher hemoglobinMedication pickupClinical dataOutcome treatmentNational guidelinesCase findingZambézia Province
2013
Bacteremia as a Cause of Fever in Ambulatory, HIV-Infected Mozambican Adults: Results and Policy Implications from a Prospective Observational Study
Moon TD, Silva WP, Buene M, Morais L, Valverde E, Vermund SH, Brentlinger PE. Bacteremia as a Cause of Fever in Ambulatory, HIV-Infected Mozambican Adults: Results and Policy Implications from a Prospective Observational Study. PLOS ONE 2013, 8: e83591. PMID: 24386229, PMCID: PMC3875454, DOI: 10.1371/journal.pone.0083591.Peer-Reviewed Original ResearchConceptsProspective observational studyAmbulatory HIVFebrile patientsObservational studySusceptibility patternsLarge prospective observational studyT-lymphocyte countsSpecific antimicrobial therapyCause of feverCases of bacteremiaFirst-line antibioticsPeripheral health unitsAntimicrobial susceptibility patternsNon-physician cliniciansNon-typhoid SalmonellaResource-limited settingsBlood culture specimensLow CD4Presumptive antibioticsClinical characteristicsRecent feverClinical profileLower hemoglobinPrescribing practicesAntimicrobial therapyOptimizing PMTCT service delivery in rural North-Central Nigeria: Protocol and design for a cluster randomized study
Aliyu MH, Blevins M, Audet C, Shepherd BE, Hassan A, Onwujekwe O, Gebi UI, Kalish M, Lindegren ML, Vermund SH, Wester CW. Optimizing PMTCT service delivery in rural North-Central Nigeria: Protocol and design for a cluster randomized study. Contemporary Clinical Trials 2013, 36: 187-197. PMID: 23816493, PMCID: PMC3786261, DOI: 10.1016/j.cct.2013.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Retroviral AgentsCD4 Lymphocyte CountCost-Benefit AnalysisFamilyFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaternal-Child Health CentersMentorsNigeriaPatient SatisfactionPoint-of-Care SystemsPregnancyPrenatal CareResearch DesignRural PopulationSocioeconomic FactorsConceptsAntiretroviral therapyPMTCT servicesChild transmissionHIV service integrationPMTCT service deliveryPMTCT service provisionChild HIV transmissionPrevention of motherCell count testingSimilar resource-limited settingsRural health facilitiesRural North-Central NigeriaResource-limited settingsPatient care responsibilitiesPMTCT careMore HIVHIV infectionCare CD4Cell count resultsHIV transmissionPregnant womenUNAIDS/Health facilitiesHealth providersInfluential community members
2010
Cost comparison of microscopy vs. empiric treatment for malaria in southwestern nigeria: a prospective study
Parikh R, Amole I, Tarpley M, Gbadero D, Davidson M, Vermund SH. Cost comparison of microscopy vs. empiric treatment for malaria in southwestern nigeria: a prospective study. Malaria Journal 2010, 9: 371. PMID: 21176228, PMCID: PMC3152770, DOI: 10.1186/1475-2875-9-371.Peer-Reviewed Original ResearchConceptsEmpiric treatmentAnti-malarial drugsClinical diagnosisClinical malariaGiemsa smearsMajority of patientsUniversity Teaching HospitalCases of malariaRapid diagnostic testsResource-limited settingsCost of diagnosisBody achesHospital chargesProspective studyTreatment optionsPatient costsPediatric regimenTeaching hospitalDiagnostic confirmationEmpirical treatmentThick smearsClinician judgmentAntimalarial drugsDrug resistanceMalaria
2009
Predictors of Rapid HIV Testing Acceptance and Successful Nevirapine Administration in Zambian Labor Wards
Megazzini KM, Chintu N, Vermund SH, Redden DT, Krebs DW, Simwenda M, Tambatamba B, Sinkala M, Stringer JS. Predictors of Rapid HIV Testing Acceptance and Successful Nevirapine Administration in Zambian Labor Wards. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 52: 273-279. PMID: 19568175, DOI: 10.1097/qai.0b013e3181ab6e7c.Peer-Reviewed Original ResearchConceptsNevirapine administrationHIV testingHIV statusHIV testing acceptanceChild transmission servicesTime of admissionProvision of HIVResource-limited settingsSusceptible womenEligible womenPrimigravida womenHIV counselingCervical dilationLabour wardTesting acceptanceEligibility criteriaTesting ratesInert tabletsWomenHIVAdministrationCounselingPredictorsHoursStatus
2008
Predictors of Adherence to Antiretroviral Therapy in Rural Zambia
Carlucci JG, Kamanga A, Sheneberger R, Shepherd BE, Jenkins CA, Spurrier J, Vermund SH. Predictors of Adherence to Antiretroviral Therapy in Rural Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2008, 47: 615-622. PMID: 18209678, PMCID: PMC2743102, DOI: 10.1097/qai.0b013e318165dc25.Peer-Reviewed Original ResearchConceptsRural health facilitiesHIV/AIDS careRural ZambiaBetter clinical outcomesBody mass indexHIV drug resistancePredictors of adherenceResource-limited settingsAntiretroviral therapyAIDS stagePatient demographicsPill countPharmacy recordsClinical outcomesMass indexAdherence ratesClinical indicesAIDS careAdherence levelsHealth facilitiesOptimize outcomesPatient's homeMission hospitalPatientsStudy participantsBuilding Global Health Through a Center-Without-Walls: The Vanderbilt Institute for Global Health
Vermund SH, Sahasrabuddhe VV, Khedkar S, Jia Y, Etherington C, Vergara A. Building Global Health Through a Center-Without-Walls: The Vanderbilt Institute for Global Health. Academic Medicine 2008, 83: 154-164. PMID: 18303361, PMCID: PMC2564795, DOI: 10.1097/acm.0b013e318160b76c.Peer-Reviewed Original ResearchConceptsGlobal healthResource-limited settingsHealth sciences graduate studentsExtramural supportHealth servicesMedical careHealth encompassesClinical fellowsDisease controlSchool of MedicineHealth ProjectNational InstituteResearch training programsTropical MedicineHealth researchPublic healthVanderbilt InstituteHealthGlobal health researchInternational health projectsTraining programService initiativesMedicineCenterInstitute
2007
Complete Blood Cell Count as a Surrogate CD4 Cell Marker for HIV Monitoring in Resource-Limited Settings
Chen RY, Westfall AO, Hardin JM, Miller-Hardwick C, Stringer JS, Raper JL, Vermund SH, Gotuzzo E, Allison J, Saag MS. Complete Blood Cell Count as a Surrogate CD4 Cell Marker for HIV Monitoring in Resource-Limited Settings. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2007, 44: 525-530. PMID: 17259910, DOI: 10.1097/qai.0b013e318032385e.Peer-Reviewed Original ResearchConceptsBirmingham Veterans Affairs Medical CenterTotal lymphocyte countCells/microLCD4 countVeterans Affairs Medical CenterComplete blood cell countAntiretroviral treatment statusLow CD4 cellsBody mass indexBlood cell countCells/Receiver operator characteristic curveResource limited settingsObservational databaseResource-limited settingsCD4 cellsLymphocyte count
2004
Antiretroviral therapy in sub-Saharan Africa: adherence lessons from tuberculosis and leprosy
Reid SE, Reid CA, Vermund SH. Antiretroviral therapy in sub-Saharan Africa: adherence lessons from tuberculosis and leprosy. International Journal Of STD & AIDS 2004, 15: 713-716. PMID: 15537453, DOI: 10.1258/0956462042395195.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyInfected personsAntiretroviral treatment programAntiretroviral drug therapyHuman immunodeficiency virusResource-limited settingsAdherence strategiesImmunodeficiency virusSaharan AfricaAdequate adherenceDrug therapyDrug costsLeprosy controlTreatment programTherapyTuberculosisLeprosyAdherenceControl programsPriorities for Antiretroviral Therapy Research in Sub-Saharan Africa
Zulu I, Schuman P, Musonda R, Chomba E, Mwinga K, Sinkala M, Chisembele M, Mwaba P, Kasonde D, Vermund SH. Priorities for Antiretroviral Therapy Research in Sub-Saharan Africa. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2004, 36: 831-834. PMID: 15213567, PMCID: PMC2745050, DOI: 10.1097/00126334-200407010-00010.Peer-Reviewed Original ResearchConceptsAntiretroviral clinical trialsClinical trialsActive antiretroviral therapyAvailability of HAARTImpact of nonadherenceResource-constrained countriesResource-limited settingsHome-based care servicesAntiretroviral therapyPublic health contextART availabilityDrug costsClinical careTherapy researchConsensus conferenceViral resistanceResearch prioritiesCare servicesGeneric medicationsSuch trialsTherapeutic resourcesTrialsHAARTHIVUrgent research priority
2003
Developing a Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Therapeutic Research Agenda for Resource-Limited Countries: A Consensus Statement
Vermund SH, Powderly WG, Association of IDSA O. Developing a Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome Therapeutic Research Agenda for Resource-Limited Countries: A Consensus Statement. Clinical Infectious Diseases 2003, 37: s4-s12. PMID: 12822127, DOI: 10.1086/375367.Peer-Reviewed Original ResearchConceptsResource-limited countriesAntiretroviral therapyResource-limited settingsDelivery of ARTImmunodeficiency syndrome careClinical Trials NetworkHealth care providersResource limited countriesHealth care practitionersHealth care advocatesHIV diseaseHIV/Consensus statementTreatment accessCare providersCare practitionersTrials NetworkART provisionCare advocatesTherapyMillions of peoplePharmaceutical expertsPatient monitoringCommunity representativesDiseasePrevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia
Stringer EM, Sinkala M, Stringer J, Mzyece E, Makuka I, Goldenberg RL, Kwape P, Chilufya M, Vermund SH. Prevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia. AIDS 2003, 17: 1377-1382. PMID: 12799559, PMCID: PMC2745990, DOI: 10.1097/00002030-200306130-00012.Peer-Reviewed Original ResearchConceptsPrevention of motherResource-limited settingsHIV infectionVoluntary counselingChild HIV transmissionPerinatal HIV infectionHIV prevention programsNVP therapyChild transmissionPatient attritionHIV transmissionPregnant womenPrevention programsNevirapineHIVHealth employeesThousands of womenTransmission routesLusakaMothersInfectionPreventionWomenCounselingInfants