2016
Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial
Aliyu MH, Blevins M, Audet CM, Kalish M, Gebi UI, Onwujekwe O, Lindegren ML, Shepherd BE, Wester CW, Vermund SH. Integrated prevention of mother-to-child HIV transmission services, antiretroviral therapy initiation, and maternal and infant retention in care in rural north-central Nigeria: a cluster-randomised controlled trial. The Lancet HIV 2016, 3: e202-e211. PMID: 27126487, PMCID: PMC4852280, DOI: 10.1016/s2352-3018(16)00018-7.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdolescentAdultAnti-HIV AgentsCD4 Lymphocyte CountDelivery of Health Care, IntegratedEarly Intervention, EducationalFamilyFemaleHIV InfectionsHumansInfantInfectious Disease Transmission, VerticalMaleMothersNevirapineNigeriaPregnancyPregnancy Complications, InfectiousPrenatal CareRural PopulationYoung AdultConceptsChild HIV transmissionAntiretroviral therapyStandard of careRural North-Central NigeriaWeeks post partumIntervention groupAntiretroviral prophylaxisEligible womenHIV statusHIV transmissionSecondary level health care facilitiesChild HIV transmission servicesClinical stage 1 diseasePost partumEunice Kennedy Shriver National InstituteMedian CD4 countPMTCT service deliveryAntiretroviral therapy initiationCD4 cell countPrevention of motherStage 1 diseaseUnknown HIV statusElimination of motherNorth Central NigeriaEarly infant diagnosis
2013
Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia
Vermund SH, Fidler SJ, Ayles H, Beyers N, Hayes RJ. Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s221-s227. PMID: 23764639, PMCID: PMC3739051, DOI: 10.1097/qai.0b013e318299c3f4.Peer-Reviewed Original ResearchConceptsHIV Prevention Trials NetworkHPTN 071 (PopART) studyHPTN 071HIV incidenceHIV transmissionHome-based HIV testingVoluntary medical male circumcisionGeneralized epidemic settingsLinkage of HIVUniversal antiretroviral therapyChild HIV transmissionPrevention of motherHIV viral loadCommunity health workersMedical male circumcisionCommunity-randomized trialIntervention strategiesCombination prevention strategiesAntiretroviral therapyHIV acquisitionSeropositive personsTuberculosis servicesHIV testingViral loadTuberculosis transmissionOptimizing PMTCT service delivery in rural North-Central Nigeria: Protocol and design for a cluster randomized study
Aliyu MH, Blevins M, Audet C, Shepherd BE, Hassan A, Onwujekwe O, Gebi UI, Kalish M, Lindegren ML, Vermund SH, Wester CW. Optimizing PMTCT service delivery in rural North-Central Nigeria: Protocol and design for a cluster randomized study. Contemporary Clinical Trials 2013, 36: 187-197. PMID: 23816493, PMCID: PMC3786261, DOI: 10.1016/j.cct.2013.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Retroviral AgentsCD4 Lymphocyte CountCost-Benefit AnalysisFamilyFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaternal-Child Health CentersMentorsNigeriaPatient SatisfactionPoint-of-Care SystemsPregnancyPrenatal CareResearch DesignRural PopulationSocioeconomic FactorsConceptsAntiretroviral therapyPMTCT servicesChild transmissionHIV service integrationPMTCT service deliveryPMTCT service provisionChild HIV transmissionPrevention of motherCell count testingSimilar resource-limited settingsRural health facilitiesRural North-Central NigeriaResource-limited settingsPatient care responsibilitiesPMTCT careMore HIVHIV infectionCare CD4Cell count resultsHIV transmissionPregnant womenUNAIDS/Health facilitiesHealth providersInfluential community membersTranslation of Biomedical Prevention Strategies for HIV
Vermund SH, Tique JA, Cassell HM, Pask ME, Ciampa PJ, Audet CM. Translation of Biomedical Prevention Strategies for HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s12-s25. PMID: 23673881, PMCID: PMC3725750, DOI: 10.1097/qai.0b013e31829202a2.Peer-Reviewed Original ResearchConceptsPrevention of motherPrevention strategiesClean injection equipmentChild HIV transmissionBiomedical approachBiomedical prevention strategiesRisk of acquisitionHIV prevention strategiesBehavioral risk reductionHigh-prevalence regionsRisk of transmissionCircumcision of menBlood product safetyChild transmissionHIV transmissionAntiretroviral drugsPrevalence regionsHIV preventionHIVFamily planningMore childrenPreventionRisk reductionInjection equipmentSaharan Africa
2008
Prevention of mother-to-child HIV transmission and management of paediatric HIV infection in Jamaica.
Vermund SH, Krogstad PA. Prevention of mother-to-child HIV transmission and management of paediatric HIV infection in Jamaica. West Indian Medical Journal 2008, 57: 187-8. PMID: 19583116.Peer-Reviewed Original ResearchConceptsPediatric HIV infectionChild HIV transmissionPrevention of motherHIV infectionHIV transmissionInfectionPreventionDo Targeted HIV Programs Improve Overall Care for Pregnant Women?
Potter D, Goldenberg RL, Chao A, Sinkala M, Degroot A, Stringer JS, Bulterys M, Vermund SH. Do Targeted HIV Programs Improve Overall Care for Pregnant Women? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2008, 47: 79-85. PMID: 17984757, PMCID: PMC2745056, DOI: 10.1097/qai.0b013e31815d2f71.Peer-Reviewed Original ResearchConceptsPrevalence odds ratiosHIV programsPMTCT programme implementationChild HIV transmissionPrevention of motherConfidence intervalsRoutine clinical servicesDisease-specific researchHealth policy makersAntenatal clinicSyphilis treatmentHIV transmissionPregnant womenOverall careOdds ratioFirst visitCare impactClinical servicesService programsImplementation of researchScreeningProgram implementationClinicVisitsCare
2007
Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine
H BH, Sinkala M, Stringer EM, Cantrell RA, Mtonga V, Bulterys M, Zulu I, Kankasa C, Wilfert C, Weidle PJ, Vermund SH, Stringer J. Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine. AIDS 2007, 21: 957-964. PMID: 17457089, PMCID: PMC2745970, DOI: 10.1097/qad.0b013e32810996b2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountDrug Administration ScheduleEpidemiologic MethodsFemaleHIV InfectionsHumansInfectious Disease Transmission, VerticalNevirapinePregnancyPregnancy Complications, InfectiousReverse Transcriptase InhibitorsTreatment FailureTreatment OutcomeConceptsSingle-dose nevirapineClinical treatment failureCD4 cell responseAntiretroviral therapyTreatment failureNVP exposureTreatment outcomesCell responsesShort-term treatment outcomesPrior exposureChild HIV transmissionPrevention of motherCD4 cell changesPoor treatment outcomesNon-nucleoside reverseSignificant differencesWorld Health Organization guidelinesHealth Organization guidelinesART initiationCohort evaluationMultivariable analysisHIV transmissionHIV treatmentRisk factorsImmune response
2005
Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia
Stringer JS, Sinkala M, Maclean CC, Levy J, Kankasa C, DeGroot A, Stringer EM, Acosta EP, Goldenberg RL, Vermund SH. Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia. AIDS 2005, 19: 1309-1315. PMID: 16052086, PMCID: PMC2745046, DOI: 10.1097/01.aids.0000180102.88511.7d.Peer-Reviewed Original ResearchConceptsMother-infant pairsHIV testingCord bloodSurveillance populationAntenatal HIV testingPerinatal HIV preventionProportion of HIVChild HIV transmissionHIV test resultsMain outcome measuresNewborn cord bloodHIV prevention programsHIV serologyInfant dosePublic sector facilitiesSeropositive womenAntenatal careHIV transmissionPrescribed regimenCascade of eventsLabor onsetPopulation effectivenessSurveillance periodHIV preventionOutcome measures
2004
Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings
Stringer J, Sinkala M, Goldenberg RL, Kumwenda R, Acosta EP, Aldrovandi GM, Stout JP, Vermund SH. Universal nevirapine upon presentation in labor to prevent mother-to-child HIV transmission in high prevalence settings. AIDS 2004, 18: 939-943. PMID: 15060442, PMCID: PMC2745979, DOI: 10.1097/00002030-200404090-00012.Peer-Reviewed Original ResearchConceptsChild HIV transmissionUnknown HIV serostatusHIV serostatusHIV transmissionPreliminary efficacyLabour wardHIV DNA polymerase chain reactionSingle-dose nevirapinePrevention of motherProspective cohort studyEvidence of infectionHigh-prevalence settingsWeeks of lifeNevirapine administrationNevirapine coverageChild transmissionCohort studyComparison cohortAdherence ratesPrevalence settingsPolymerase chain reactionCord bloodDNA polymerase chain reactionHIVInfant specimens
2003
Mother-to-child HIV transmission prevention in Thailand: physician zidovudine use and willingness to provide care
Bhatta MP, Stringer JS, Phanuphak P, Vermund SH. Mother-to-child HIV transmission prevention in Thailand: physician zidovudine use and willingness to provide care. International Journal Of STD & AIDS 2003, 14: 404-410. PMID: 12816669, DOI: 10.1258/095646203765371303.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsAttitude of Health PersonnelDrug UtilizationFamily PracticeFemaleGynecologyHealth Knowledge, Attitudes, PracticeHIV InfectionsHumansInfectious Disease Transmission, VerticalLogistic ModelsMaleMultivariate AnalysisObstetricsPhysiciansPractice Patterns, Physicians'PregnancyPregnancy Complications, InfectiousSurveys and QuestionnairesThailandZidovudineConceptsZidovudine useObstetric careChild HIV transmission preventionMultivariable logistic regression analysisPerinatal zidovudine prophylaxisCaesarean section deliveryChild HIV transmissionHIV-positive womenHIV transmission preventionPredictors of failureThai physiciansLogistic regression analysisAntiretroviral useAntiretroviral therapySection deliveryAntenatal careCaesarean sectionVaginal deliveryZidovudine prophylaxisHIV transmissionPregnant womenElective terminationPelvic examinationTransmission preventionHIVPrevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia
Stringer EM, Sinkala M, Stringer J, Mzyece E, Makuka I, Goldenberg RL, Kwape P, Chilufya M, Vermund SH. Prevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia. AIDS 2003, 17: 1377-1382. PMID: 12799559, PMCID: PMC2745990, DOI: 10.1097/00002030-200306130-00012.Peer-Reviewed Original ResearchConceptsPrevention of motherResource-limited settingsHIV infectionVoluntary counselingChild HIV transmissionPerinatal HIV infectionHIV prevention programsNVP therapyChild transmissionPatient attritionHIV transmissionPregnant womenPrevention programsNevirapineHIVHealth employeesThousands of womenTransmission routesLusakaMothersInfectionPreventionWomenCounselingInfants