2019
Cracking the Cell Death Code
Rothlin CV, Ghosh S. Cracking the Cell Death Code. Cold Spring Harbor Perspectives In Biology 2019, 12: a036343. PMID: 31548182, PMCID: PMC7197433, DOI: 10.1101/cshperspect.a036343.Peer-Reviewed Original Research
2003
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 2003, 4: 499-515. PMID: 14706341, DOI: 10.1016/s1535-6108(03)00304-0.Peer-Reviewed Original ResearchMeSH KeywordsBeta CateninCadherinsCaveolaeCaveolin 1CaveolinsCell AdhesionCell MovementCell NucleusCytoskeletal ProteinsDNA-Binding ProteinsDown-RegulationEndocytosisEpidermal Growth FactorErbB ReceptorsGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansIntercellular JunctionsNeoplasm MetastasisRNA, AntisenseSignal TransductionSnail Family Transcription FactorsTrans-ActivatorsTranscription FactorsTranscriptional ActivationTumor Cells, CulturedConceptsTranscriptional activityCaveolin-1Cell-cell adhesion proteinsCaveolin-1 functionCell-cell adhesionEGF receptor overexpressionE-cadherinCaveolin-dependent endocytosisTCF/LEFTranscriptional repressor SnailComplex cellular changesCaveolin-1 expressionChronic EGF treatmentTumor cell invasionEGF-induced effectsCaveolin-1 downregulationAdhesion proteinsNegative regulationTranscriptional downregulationAntisense RNAGSK-3betaE-cadherin expressionEGF treatmentHuman tumor cellsCell invasion
2001
Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation
Ghosh S, Cox J. Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation. Molecular Biology Of The Cell 2001, 12: 3864-3874. PMID: 11739786, PMCID: PMC60761, DOI: 10.1091/mbc.12.12.3864.Peer-Reviewed Original ResearchConceptsCytoskeletal associationPhosphatase inhibitorErythroid ankyrinErythroid cellsEmbryonic erythroid cellsRole of phosphorylationAE1 anion exchangerTreatment of cellsBind spectrinAnkyrin isoformsAnkyrinCytoskeletal spectrinDynamic rearrangementPhosphorylationSoluble poolVivo consequencesSpectrinComplex formationSerineRapid cyclesIsoformsCellsPoolInhibitorsComplexes