2010
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression
Teo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, Chanda SK, Verma IM, Tergaonkar V. Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression. Nature Cell Biology 2010, 12: 758-767. PMID: 20622870, DOI: 10.1038/ncb2080.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternCell LineCell Line, TumorChromatin ImmunoprecipitationChromatography, GelHeLa CellsHumansI-kappa B KinaseImmunohistochemistryImmunoprecipitationKaplan-Meier EstimateMiceNF-kappa BPhosphorylationPolymerase Chain ReactionProtein BindingRNA, Small InterferingShelterin ComplexTelomere-Binding ProteinsTissue Array Analysis
2006
Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survival
Ghosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P, Verma IM, Hunter T. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survival. Cancer Cell 2006, 10: 215-226. PMID: 16959613, DOI: 10.1016/j.ccr.2006.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell SurvivalDNA DamageFibroblastsMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Monomeric GTP-Binding ProteinsNeuropeptidesNF-kappa BProto-Oncogene Proteins c-aktRas Homolog Enriched in Brain ProteinRNA, Small InterferingTranscription, GeneticTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinTumor Necrosis Factor-alphaTumor Suppressor ProteinsConceptsNF-kappaB activationNF-kappaB transcriptional activationNF-κB activationNF-kappaB functionNF-kappaB signalingCell survivalPI-3K pathwayImportant survival factorActivity-dependent mannerTuberous sclerosis gene TSC1MTOR pathwayERK1/2 MAP kinasesReduced survivalSurvival factorK pathwayMTOR activityTSC2 expressionSurvivalCell survival responseGenes TSC1TNFalpha stimulationActivationInhibitionMAP kinaseInduction pathway