2015
Endosomal regulation of contact inhibition through the AMOT:YAP pathway
Cox CM, Mandell EK, Stewart L, Lu R, Johnson DL, McCarter SD, Tavares A, Runyan R, Ghosh S, Wilson JM. Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Molecular Biology Of The Cell 2015, 26: 2673-2684. PMID: 25995376, PMCID: PMC4501364, DOI: 10.1091/mbc.e15-04-0224.Peer-Reviewed Original ResearchConceptsEndosomal membranesYAP activitySubconfluent cellsOrgan growth controlTranscription coactivator YesPhosphorylation-dependent regulationIntegral membrane proteinsConfluent cellsAmot proteinsEndosomal regulationContact-mediated inhibitionCytoplasmic domainEndotubinMembrane proteinsOvergrowth phenotypeInduces translocationAngiomotinYAP interactionDirect bindingGrowth controlContact inhibitionFamily membersCell growthYAPYAP pathway
2003
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 2003, 4: 499-515. PMID: 14706341, DOI: 10.1016/s1535-6108(03)00304-0.Peer-Reviewed Original ResearchMeSH KeywordsBeta CateninCadherinsCaveolaeCaveolin 1CaveolinsCell AdhesionCell MovementCell NucleusCytoskeletal ProteinsDNA-Binding ProteinsDown-RegulationEndocytosisEpidermal Growth FactorErbB ReceptorsGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHumansIntercellular JunctionsNeoplasm MetastasisRNA, AntisenseSignal TransductionSnail Family Transcription FactorsTrans-ActivatorsTranscription FactorsTranscriptional ActivationTumor Cells, CulturedConceptsTranscriptional activityCaveolin-1Cell-cell adhesion proteinsCaveolin-1 functionCell-cell adhesionEGF receptor overexpressionE-cadherinCaveolin-dependent endocytosisTCF/LEFTranscriptional repressor SnailComplex cellular changesCaveolin-1 expressionChronic EGF treatmentTumor cell invasionEGF-induced effectsCaveolin-1 downregulationAdhesion proteinsNegative regulationTranscriptional downregulationAntisense RNAGSK-3betaE-cadherin expressionEGF treatmentHuman tumor cellsCell invasion