2014
Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma
Kusne Y, Carrera-Silva EA, Perry AS, Rushing EJ, Mandell EK, Dietrich JD, Errasti AE, Gibbs D, Berens ME, Loftus JC, Hulme C, Yang W, Lu Z, Aldape K, Sanai N, Rothlin CV, Ghosh S. Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Science Signaling 2014, 7: ra75. PMID: 25118327, PMCID: PMC4486020, DOI: 10.1126/scisignal.2005196.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinogenesisDrug Delivery SystemsEnzyme-Linked Immunosorbent AssayEpidermal Growth FactorErbB ReceptorsErlotinib HydrochlorideFlow CytometryFluorescent Antibody TechniqueGlioblastomaHumansImmunoblottingImmunohistochemistryImmunoprecipitationKaplan-Meier EstimateMiceNF-kappa BParacrine CommunicationProtein Kinase CQuinazolinesReverse Transcriptase Polymerase Chain ReactionSignal TransductionTumor Necrosis Factor-alphaConceptsAtypical protein kinase CEpidermal growth factor receptorEGFR kinase inhibitorsHuman glioblastoma tumor cellsReceptor tyrosine kinasesProtein kinase CTNFα-dependent activationKinase inhibitorsTranscription factor nuclear factor κBGlioblastoma tumor cellsGrowth factor receptorKinase activityMolecular approachesTyrosine kinaseKinase CNuclear factor κBFactor receptorGlioblastoma microenvironmentFactor κBProinflammatory cytokine TNFαAbundanceTumor necrosis factorGlioblastoma therapyTumor growthGrade IV glioblastoma
2006
Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survival
Ghosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P, Verma IM, Hunter T. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survival. Cancer Cell 2006, 10: 215-226. PMID: 16959613, DOI: 10.1016/j.ccr.2006.08.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCell SurvivalDNA DamageFibroblastsMAP Kinase Signaling SystemMiceMice, KnockoutMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Monomeric GTP-Binding ProteinsNeuropeptidesNF-kappa BProto-Oncogene Proteins c-aktRas Homolog Enriched in Brain ProteinRNA, Small InterferingTranscription, GeneticTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinTumor Necrosis Factor-alphaTumor Suppressor ProteinsConceptsNF-kappaB activationNF-kappaB transcriptional activationNF-κB activationNF-kappaB functionNF-kappaB signalingCell survivalPI-3K pathwayImportant survival factorActivity-dependent mannerTuberous sclerosis gene TSC1MTOR pathwayERK1/2 MAP kinasesReduced survivalSurvival factorK pathwayMTOR activityTSC2 expressionSurvivalCell survival responseGenes TSC1TNFalpha stimulationActivationInhibitionMAP kinaseInduction pathway