aPKC in neuronal differentiation, maturation and function
Hapak SM, Rothlin CV, Ghosh S. aPKC in neuronal differentiation, maturation and function. Neuronal Signaling 2019, 3: ns20190019. PMID: 32269838, PMCID: PMC7104321, DOI: 10.1042/ns20190019.BooksProtein kinase C (PKC) familyAtypical protein kinase CsProtein kinase CsKey metabolic functionsNervous system developmentHuman neuropsychiatric diseasesC familyCellular responsesAPKCsNeural developmentNeuronal differentiationFunctional roleMetabolic functionsNervous systemNeuronal maturationNeuronal functionGenetic deletionKinaseGlucose uptakeDifferentiationLikely candidateMaturationNeuropsychiatric diseasesSubfamiliesPRKCIApical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function
Scott J, Thakar S, Mao Y, Qin H, Hejran H, Lee SY, Yu T, Klezovitch O, Cheng H, Mu Y, Ghosh S, Vasioukhin V, Zou Y. Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. IScience 2019, 20: 25-41. PMID: 31546104, PMCID: PMC6817635, DOI: 10.1016/j.isci.2019.09.005.Peer-Reviewed Original ResearchAtypical protein kinase CsApical-basal polarity proteinsPolarity proteinsPlanar cell polarity proteinsCell polarity proteinsConditional knockoutSynapse formationProtein kinase CsSmith-Magenis syndromeGlutamatergic synapse developmentSynapse numberKnockout embryosSignaling ComponentsSynapse developmentNormal synapse formationLgl1ProteinPostsynaptic densityCultured cortical neuronsKnockoutSynaptosome fractionVangl2EmbryosImpaired plasticityCortical neurons