2017
Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal
Hughes LD, Bosurgi L, Ghosh S, Rothlin CV. Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal. Frontiers In Immunology 2017, 8: 1743. PMID: 29312294, PMCID: PMC5732325, DOI: 10.3389/fimmu.2017.01743.BooksApoptotic cellsApoptotic cell clearanceBillions of cellsExposure of phosphatidylserinePtdSer exposurePlasma membraneConstant remodelingOuter leafletSilent removalApoptotic bodiesUbiquitous signalCell clearanceMassive turnoverShedding of cellsTissue repairGrowth factorMechanisms of disposalApoptosisCellsEmergent propertiesPhagocytesHomeostasisBarrier surfacesPhosphatidylserineImmunological settings
2015
PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels
Lu R, Dalgalan D, Mandell EK, Parker SS, Ghosh S, Wilson JM. PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Molecular Biology Of The Cell 2015, 26: 1523-1531. PMID: 25694446, PMCID: PMC4395131, DOI: 10.1091/mbc.e14-12-1613.Peer-Reviewed Original ResearchConceptsClaudin-2 levelsSmall GTPase Rab14Claudin-2 protein levelsClaudin-2Junction proteinsTransepithelial resistanceEpithelial polarityIntracellular punctaTight junction componentsTight junction proteinsPlasma membraneNormal assemblyRab14 expressionRab14Junction componentsPKCιKnockdownEpithelial barrier functionProtein levelsTight junctionsZO-1ProteinParacellular permeabilityClaudin-1APKC