Featured Publications
Cell death in development, maintenance, and diseases of the nervous system
Mercau ME, Patwa S, Bhat KPL, Ghosh S, Rothlin CV. Cell death in development, maintenance, and diseases of the nervous system. Seminars In Immunopathology 2022, 44: 725-738. PMID: 35508671, DOI: 10.1007/s00281-022-00938-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCell deathTissue-level responsesNervous system homeostasisNervous systemCentral nervous system tumorsMolecular modalitiesAcute brain injuryNervous system tumorsChronic neurodegenerative diseasesSystem homeostasisDead cellsNew therapeutic strategiesNeurodegenerative diseasesMechanisms of disposalGlial cellsNovel understandingAdult neurogenesisSystem tumorsBrain injuryPathological responseDisease statesTherapeutic strategiesCellsRecent studiesDeath
2019
aPKC in neuronal differentiation, maturation and function
Hapak SM, Rothlin CV, Ghosh S. aPKC in neuronal differentiation, maturation and function. Neuronal Signaling 2019, 3: ns20190019. PMID: 32269838, PMCID: PMC7104321, DOI: 10.1042/ns20190019.BooksProtein kinase C (PKC) familyAtypical protein kinase CsProtein kinase CsKey metabolic functionsNervous system developmentHuman neuropsychiatric diseasesC familyCellular responsesAPKCsNeural developmentNeuronal differentiationFunctional roleMetabolic functionsNervous systemNeuronal maturationNeuronal functionGenetic deletionKinaseGlucose uptakeDifferentiationLikely candidateMaturationNeuropsychiatric diseasesSubfamiliesPRKCI