Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function
Scott J, Thakar S, Mao Y, Qin H, Hejran H, Lee SY, Yu T, Klezovitch O, Cheng H, Mu Y, Ghosh S, Vasioukhin V, Zou Y. Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. IScience 2019, 20: 25-41. PMID: 31546104, PMCID: PMC6817635, DOI: 10.1016/j.isci.2019.09.005.Peer-Reviewed Original ResearchAtypical protein kinase CsApical-basal polarity proteinsPolarity proteinsPlanar cell polarity proteinsCell polarity proteinsConditional knockoutSynapse formationProtein kinase CsSmith-Magenis syndromeGlutamatergic synapse developmentSynapse numberKnockout embryosSignaling ComponentsSynapse developmentNormal synapse formationLgl1ProteinPostsynaptic densityCultured cortical neuronsKnockoutSynaptosome fractionVangl2EmbryosImpaired plasticityCortical neurons