2013
Competing molecular interactions of aPKC isoforms regulate neuronal polarity
Parker SS, Mandell EK, Hapak SM, Maskaykina IY, Kusne Y, Kim JY, Moy JK, St. John PA, Wilson JM, Gothard KM, Price TJ, Ghosh S. Competing molecular interactions of aPKC isoforms regulate neuronal polarity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 14450-14455. PMID: 23940317, PMCID: PMC3761571, DOI: 10.1073/pnas.1301588110.Peer-Reviewed Original ResearchConceptsAtypical protein kinase CNeuronal polarityAPKC isoformsProtein kinase CCell polarityPolarized neuronsAlternative transcriptsKinase CPar3Supernumerary axonsIsoformsEmbryonic hippocampal neuronsMolecular interactionsOverexpressionPresumptive axonsMolecular modelHippocampal neuronsPolarityPKMTranscriptsRegulatorIntermolecular competitionInteractsNeuronsDisrupts
2001
Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation
Ghosh S, Cox J. Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation. Molecular Biology Of The Cell 2001, 12: 3864-3874. PMID: 11739786, PMCID: PMC60761, DOI: 10.1091/mbc.12.12.3864.Peer-Reviewed Original ResearchConceptsCytoskeletal associationPhosphatase inhibitorErythroid ankyrinErythroid cellsEmbryonic erythroid cellsRole of phosphorylationAE1 anion exchangerTreatment of cellsBind spectrinAnkyrin isoformsAnkyrinCytoskeletal spectrinDynamic rearrangementPhosphorylationSoluble poolVivo consequencesSpectrinComplex formationSerineRapid cyclesIsoformsCellsPoolInhibitorsComplexes