Prothrombotic Phenotype of a Protein S Mutant Lacking Anticoagulant Activity
Springborn S, Ghosh S, Schulte M, Rothlin C, Branchford B. Prothrombotic Phenotype of a Protein S Mutant Lacking Anticoagulant Activity. Blood 2021, 138: 2098. DOI: 10.1182/blood-2021-153904.Peer-Reviewed Original ResearchProtein STAM familyPlatelet activationReceptor tyrosine kinasesCremaster muscle microvasculatureProtein CPulmonary embolism modelWild-type littermatesWild-type animalsTyrosine kinaseVascular injuryMuscle microvasculaturePlatelet responsivenessProthrombotic phenotypeInjury siteCoagulation factor VTail veinEmbolism modelHeterozygous littermatesLaser injuryVitamin KHomozygous miceMiceAnticoagulant activityNovo Nordisk