2024
Role of Valosin-Containing Protein (VCP) in Ciliary Morphology and ADPKD: Exploring VCP as a Novel Genetic Interactor in Disease Progression
Pioppini C, Bhardwaj R, Fedeles S, Yilmaz D, Krappitz M. Role of Valosin-Containing Protein (VCP) in Ciliary Morphology and ADPKD: Exploring VCP as a Novel Genetic Interactor in Disease Progression. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024w6rq11tc. DOI: 10.1681/asn.2024w6rq11tc.Peer-Reviewed Original Research
2012
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells
Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Haßdenteufel S, Tatzelt J, Kreutzer B, Edelmann L, Krause E, Rettig J, Somlo S, Zimmermann R, Dudek J. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. Journal Of Cell Science 2012, 125: 1958-1969. PMID: 22375059, PMCID: PMC4074215, DOI: 10.1242/jcs.096727.Peer-Reviewed Original ResearchConceptsPost-translational transportTail-anchored proteinsSEC61A1 geneEndoplasmic reticulumTransport of polypeptidesCo-translational transportSemi-permeabilized cellsPrecursor proteinSEC62 geneSec61 channelPresecretory proteinsMembrane integrationProtein transportMammalian cellsKnockdown approachHuman cellsGenesHeLa cellsProteinPolypeptideReticulumCellsSec63pSec61αSec63