2013
Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus
Castorina A, D’Amico A, Scuderi S, Leggio G, Drago F, D’Agata V. Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience 2013, 250: 546-556. PMID: 23906635, DOI: 10.1016/j.neuroscience.2013.07.053.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternBrain-Derived Neurotrophic FactorCyclic AMP Response Element-Binding ProteinDopamine and cAMP-Regulated Phosphoprotein 32FibrinolysinGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHippocampusImmunohistochemistryLearningMaleMemoryMiceMice, KnockoutOncogene Protein v-aktPhosphorylationPrefrontal CortexReal-Time Polymerase Chain ReactionReceptors, Dopamine D3RNA, MessengerRNA, Ribosomal, 18STissue Plasminogen Activator
2011
Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate
Giunta S, Castorina A, Scuderi S, Patti C, D’Agata V. Epidermal growth factor receptor (EGFR) and neuregulin (Neu) activation in human airway epithelial cells exposed to nickel acetate. Toxicology In Vitro 2011, 26: 280-287. PMID: 22210268, DOI: 10.1016/j.tiv.2011.12.012.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorPhosphorylated proteinsGrowth factor receptorFactor receptorBcl-2Suppression of apoptosisAirway epithelial cellsEpithelial cellsReduced EGFRBax protein expressionApoptosis initiationEpithelial cell lineBEAS-2B cellsCell deathDNA fragmentationDNA damageAirway epithelial cell lineHuman airway epithelial cellsExpression levelsProteinApoptosisProtein expressionCell linesInitiation of carcinogenesisPotential involvement