2024
Septic Shock
Abdel‐Razeq S. Septic Shock. 2024, 665-695. DOI: 10.1002/9781119820260.ch38.Peer-Reviewed Original ResearchSeptic shockDysregulated inflammatory response to infectionPhysiological adaptations to pregnancyDiagnosis of septic shockInflammatory response to infectionClinical presentation of shockAdaptation to pregnancyIntravenous fluid resuscitationEarly diagnosis of septic shockInadequate tissue oxygenationIntensive care unitPresentation of shockResponse to infectionFetal outcomesClinical presentationClammy skinFluid resuscitationMetabolic acidosisCirculatory failureBiochemical abnormalitiesEarly diagnosisClinical syndromeFluid homeostasisCare unitImprove outcomes
2023
Delivery outcomes in the subsequent pregnancy following the conservative management of placenta accreta spectrum disorder: a systematic review and meta-analysis
JAVINANI A, QADERI S, HESSAMI K, SHAINKER S, SHAMSHIRSAZ A, Fox K, MUSTAFA H, SUBRAMANIAM A, KHANDELWAL M, SANDLIN A, DUZYJ C, LYELL D, ZUCKERWISE L, NEWTON J, KINGDOM J, HARRISON R, SHRIVASTAVA V, GREINER A, Loftin R, GENC M, ATASI L, ABDEL-RAZEQ S, BENNETT K, CARUSI D, EINERSON B, GILNER J, CARVER A, SILVER R, SHAMSHIRSAZ A. Delivery outcomes in the subsequent pregnancy following the conservative management of placenta accreta spectrum disorder: a systematic review and meta-analysis. American Journal Of Obstetrics And Gynecology 2023, 230: 485-492.e7. PMID: 37918506, DOI: 10.1016/j.ajog.2023.10.047.Peer-Reviewed Original ResearchPlacenta accreta spectrum disordersAdverse maternal outcomesSubsequent pregnancy outcomeConservative managementPregnancy outcomesSubsequent pregnancyMaternal outcomesCesarean hysterectomySystematic reviewComposite adverse maternal outcomeFavorable pregnancy outcomeUterine-sparing techniquesInverse variance methodSpectrum disorderRandom-effects modelMaternal morbiditySurgical complicationsPostpartum hemorrhageAdverse outcomesResection surgerySuch high incidenceDelivery outcomesHigh incidencePregnancyProvider preparation
2022
Ultrasound Image Quality Comparison Between a Handheld Ultrasound Transducer and Mid-Range Ultrasound Machine
Salimi N, Gonzalez-Fiol A, Yanez N, Fardelmann K, Harmon E, Kohari K, Abdel-Razeq S, Magriples U, Alian A. Ultrasound Image Quality Comparison Between a Handheld Ultrasound Transducer and Mid-Range Ultrasound Machine. POCUS Journal 2022, 7: 154-159. PMID: 36896280, PMCID: PMC9979954, DOI: 10.24908/pocus.v7i1.15052.Peer-Reviewed Original Research
2021
763 Hemostasis changes among COVID-19 gravidas during SARS-CoV-2 pandemic on rotational thromboelastography
Abdel-Razeq S, Alien A, Lundsberg L, Culhane J. 763 Hemostasis changes among COVID-19 gravidas during SARS-CoV-2 pandemic on rotational thromboelastography. American Journal Of Obstetrics And Gynecology 2021, 224: s477. PMCID: PMC7848490, DOI: 10.1016/j.ajog.2020.12.786.Peer-Reviewed Original Research
2020
Drug use associated tricuspid valve infective endocarditis in pregnancy
Lin D, Mullan CW, Deshmukh U, Bahtiyar MO, Hosier H, Lipkind H, Abdel‐Razeq S, Ranjan S, Lancaster G, Pietras C. Drug use associated tricuspid valve infective endocarditis in pregnancy. Journal Of Cardiac Surgery 2020, 35: 2392-2395. PMID: 32720414, DOI: 10.1111/jocs.14888.Peer-Reviewed Original ResearchConceptsDrug useTricuspid valve infective endocarditisWeeks 6 days' gestationAppropriate intravenous antibioticsTricuspid valve endocarditisLife-threatening complicationsIntravenous drug useNeonatal critical careIntravenous antibioticsCesarean deliveryPerioperative periodValve endocarditisCardiac surgeryInfective endocarditisCritical careDays gestationPatient managementPregnant femalesEndocarditisMultidisciplinary collaborationPatientsGestationComplicationsPregnancySurgery
2019
Cesarean Scar Pregnancy, Incidence, and Recurrence: Five-Year Experience at a Single Tertiary Care Referral Center
Grechukhina O, Deshmukh U, Fan L, Kohari K, Abdel-Razeq S, Bahtiyar M, Sfakianaki A. Cesarean Scar Pregnancy, Incidence, and Recurrence: Five-Year Experience at a Single Tertiary Care Referral Center. Obstetric Anesthesia Digest 2019, 39: 98-99. DOI: 10.1097/01.aoa.0000557687.83837.90.Peer-Reviewed Original ResearchCesarean scar pregnancyScar pregnancyTreatment modalitiesSingle tertiary care referral centerTertiary care referral centerYale-New Haven HospitalLife-threatening complicationsNumerous treatment modalitiesTertiary care centerOptimal treatment modalityFive-year experiencePrevious hysterotomySac implantsPregnancy outcomesReferral centerPatient counselingCare centerTreatment decisionsPregnancyAvailable literaturePresent studyModalitiesHysterotomyComplicationsRecurrenceResults From an Multidisciplinary Severe Maternal Morbidity Review at a Tertiary Academic Medical Center [23P]
Campbell K, Grechukhina O, Abdel-Razeq S, Raab C, Pettker C, Lipkind H. Results From an Multidisciplinary Severe Maternal Morbidity Review at a Tertiary Academic Medical Center [23P]. Obstetrics And Gynecology 2019, 133: 176s-176s. DOI: 10.1097/01.aog.0000559487.48795.79.Peer-Reviewed Original ResearchSevere maternal morbidityPreventable severe maternal morbidityTertiary academic medical centerMean maternal ageWomen age 40Academic medical centerObstetric safetyPlacental hemorrhageHypertensive disordersMaternal morbidityObstetric hemorrhagePatient characteristicsMaternal deathsOutside hospitalPotential preventabilityPregnant womenMaternal agePeripartum periodSMM casesCommon causeMedical CenterMaternity careMorbidity reviewAge 40PI women
2018
Septic Shock
Abdel‐Razeq S, Norwitz E. Septic Shock. 2018, 599-629. DOI: 10.1002/9781119129400.ch38.Peer-Reviewed Original ResearchSystemic inflammatory response syndromeAcute respiratory distress syndromeSeptic shockPercent of patientsGeneralized inflammatory responseInflammatory response syndromeInadequate tissue oxygenationRespiratory distress syndromeVascular smooth muscleVariety of insultsMicrobiologic pathogensFetal outcomesSevere sepsisCirculatory failureDistress syndromeResponse syndromeClinical spectrumClinical syndromeInflammatory responsePregnant hostsSmooth muscleTissue oxygenationPhysiologic adaptationsHost responseFluid homeostasisPhysiology of Pregnancy
Oliveira K, Abdel-Razeq S. Physiology of Pregnancy. Current Trauma Reports 2018, 4: 211-217. DOI: 10.1007/s40719-018-0134-2.Peer-Reviewed Original ResearchTrauma patientsPhysiologic changesPregnant trauma patientsNormal physiologic changesPhysiologic systemsPhysiology of pregnancyRelevant clinical findingsPregnant patientsClinical findingsHematologic systemTraumatic injuryGastrointestinal systemRecent FindingsWhileGenitourinary systemReviewThe purposeTrauma practitionersCardiovascular systemRespiratory systemPregnancyPatientsMusculoskeletal systemSummaryThis articleComplex physiologyLandmark studiesReview165 Cytomegalovirus, Rubella, Toxoplasmosis, Herpes Simplex Virus, and Varicella
Abdel-Razeq S, Cross S, Lipkind H, Copel J. 165 Cytomegalovirus, Rubella, Toxoplasmosis, Herpes Simplex Virus, and Varicella. 2018, 666-681.e3. DOI: 10.1016/b978-0-323-44548-1.00165-0.ChaptersCentral nervous system abnormalitiesNervous system abnormalitiesHerpes simplex virusTiming of infectionMaternal infectionFetal hydropsGrowth restrictionMultiple sequelaeSystem abnormalitiesSimplex virusVaricellaInfectionVariable responseVirusCommon effectToxoplasmosisSequelaeHydropsRubellaCytomegalovirusAbnormalities833: Severe maternal morbidity associated with hypertensive disorders of pregnancy after regionalization of perinatal care in New York City
Ackerman C, Pettker C, Goffman D, Campbell K, Platner M, Zu X, Abdel-Razeq S, Chung S, Lipkind H. 833: Severe maternal morbidity associated with hypertensive disorders of pregnancy after regionalization of perinatal care in New York City. American Journal Of Obstetrics And Gynecology 2018, 218: s496. DOI: 10.1016/j.ajog.2017.11.366.Peer-Reviewed Original Research
2014
Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth
Zuckerwise L, Nayeri U, Abdel-Razeq S, Copel J, Bahtiyar M. Doppler abnormalities in monochorionic diamniotic twin pregnancies with discordant growth. Journal Of Perinatology 2014, 35: 387-389. PMID: 25521562, DOI: 10.1038/jp.2014.223.Peer-Reviewed Original ResearchConceptsDoppler flow velocity waveformsFlow velocity waveformsDiscordant growthVelocity waveformsTwin gestationsSmall fetusesAbnormal umbilical artery Doppler flow velocity waveformsUmbilical artery Doppler flow velocity waveformsMonochorionic diamniotic twin gestationsMonochorionic diamniotic twin pregnanciesNeonatal intensive care unitDiamniotic twin gestationsMCDA twin pairsDiamniotic twin pregnanciesEnd-diastolic flowLow Apgar scoreBirth weight discordanceDiscordant fetal growthIntensive care unitTwin transfusion syndromeDoppler velocity waveformsT-testElectronic medical recordsTwin pairsStudent's t-test
2013
733: Mixed bacteria generate a differential intra-amniotic inflammatory response compared to infections with a single microbial species
Dulay A, Buhimschi C, Shook L, Zhao G, Bahtiyar M, Pettker C, Sfakianaki A, Lipkind H, Abdel-Razeq S, Buhimschi I. 733: Mixed bacteria generate a differential intra-amniotic inflammatory response compared to infections with a single microbial species. American Journal Of Obstetrics And Gynecology 2013, 208: s309. DOI: 10.1016/j.ajog.2012.10.071.Peer-Reviewed Original Research836: Limiting exposure of a select group of fetuses to intra-amniotic infection (IAI) may improve short-term neonatal outcome in pregnancies complicated by PPROM
Archabald K, Buhimschi I, Bahtiyar M, Dulay A, Abdel-Razeq S, Pettker C, Lipkind H, Hardy J, McCarthy M, Zhao G, Bhandari V, Buhimschi C. 836: Limiting exposure of a select group of fetuses to intra-amniotic infection (IAI) may improve short-term neonatal outcome in pregnancies complicated by PPROM. American Journal Of Obstetrics And Gynecology 2013, 208: s349-s350. DOI: 10.1016/j.ajog.2012.10.174.Peer-Reviewed Original Research
2012
51: Evidence for the presence of super-interleukin-6 (superIL-6) trans-signaling complex in amniotic fluid (AF) and its participation in the intraamniotic inflammatory response to infection
Abdel-Razeq S, Buhimschi I, Trotta K, Zhao G, Bahtiyar M, Pettker C, Buhimschi C. 51: Evidence for the presence of super-interleukin-6 (superIL-6) trans-signaling complex in amniotic fluid (AF) and its participation in the intraamniotic inflammatory response to infection. American Journal Of Obstetrics And Gynecology 2012, 206: s32-s33. DOI: 10.1016/j.ajog.2011.10.077.Peer-Reviewed Original Research48: Amniotic fluid (AF) soluble myeloid differentiation (MD)-2 factor as regulator of intraamniotic inflammation in infection-induced preterm birth
Dulay A, Buhimschi C, Zhao G, Lee S, Abdel-Razeq S, Bahtiyar M, Buhimschi I. 48: Amniotic fluid (AF) soluble myeloid differentiation (MD)-2 factor as regulator of intraamniotic inflammation in infection-induced preterm birth. American Journal Of Obstetrics And Gynecology 2012, 206: s31-s32. DOI: 10.1016/j.ajog.2011.10.074.Peer-Reviewed Original Research582: Haptoglobin (Hp) switch-on pattern as a biomarker of exposure to intra-amniotic inflammation in twin pregnancies
Buhimschi C, Ali U, Trotta K, Zhao G, Campbell K, Duzyj C, Papanna R, Abdel-Razeq S, Lipkind H, Bhandari V, Buhimschi I. 582: Haptoglobin (Hp) switch-on pattern as a biomarker of exposure to intra-amniotic inflammation in twin pregnancies. American Journal Of Obstetrics And Gynecology 2012, 206: s265. DOI: 10.1016/j.ajog.2011.10.600.Peer-Reviewed Original Research814: Evidence that endoglin and transforming growth factor-beta (TGFβ) participate in epithelial-to-mesenchymal transition (EMT) of extravillous trophoblasts in placenta accreta
Duzyj C, Buhimschi I, Laky C, Cozzini G, Zhao G, Wehrum M, Pettker C, Abdel-Razeq S, Buhimschi C. 814: Evidence that endoglin and transforming growth factor-beta (TGFβ) participate in epithelial-to-mesenchymal transition (EMT) of extravillous trophoblasts in placenta accreta. American Journal Of Obstetrics And Gynecology 2012, 206: s357. DOI: 10.1016/j.ajog.2011.10.832.Peer-Reviewed Original Research39: The invasive phenotype of the placenta accrete extravillous trophoblasts (EVTs) is characterized by epithelial-mesenchymal-transition (EMT) and loss of E-cadherin (E-CAD)
Duzyj C, Laky C, Cozzini G, Zhao G, Abdel-Razeq S, Funai E, Buhimschi I, Buhimschi C. 39: The invasive phenotype of the placenta accrete extravillous trophoblasts (EVTs) is characterized by epithelial-mesenchymal-transition (EMT) and loss of E-cadherin (E-CAD). American Journal Of Obstetrics And Gynecology 2012, 206: s26. DOI: 10.1016/j.ajog.2011.10.065.Peer-Reviewed Original Research
2011
Modulation of Amniotic Fluid Activin‐A and Inhibin‐A in Women With Preterm Premature Rupture of the Membranes and Infection‐Induced Preterm Birth
Rosenberg VA, Buhimschi IA, Dulay AT, Abdel‐Razeq S, Oliver EA, Duzyj CM, Lipkind H, Pettker CM, Buhimschi CS. Modulation of Amniotic Fluid Activin‐A and Inhibin‐A in Women With Preterm Premature Rupture of the Membranes and Infection‐Induced Preterm Birth. American Journal Of Reproductive Immunology 2011, 67: 122-131. PMID: 21992678, PMCID: PMC3253234, DOI: 10.1111/j.1600-0897.2011.01074.x.Peer-Reviewed Original ResearchConceptsPreterm premature rupturePreterm birthPremature ruptureVillous explantsRecombinant activinInflammation-induced preterm birthRelease of activinIntra-amniotic infectionPlacental villous explantsIL-8 releasePreterm laborInflammatory processInflammatory reactionGram-negative lipopolysaccharideInhibinFetal membranesHuman AFImportant modulatorAF samplesInfectionActivinLipopolysaccharidePPROMAmniochorionIntact membranes