2008
Fetal inflammatory response in women with proteomic biomarkers characteristic of intra‐amniotic inflammation and preterm birth
Buhimschi C, Dulay A, Abdel‐Razeq S, Zhao G, Lee S, Hodgson E, Bhandari V, Buhimschi I. Fetal inflammatory response in women with proteomic biomarkers characteristic of intra‐amniotic inflammation and preterm birth. BJOG An International Journal Of Obstetrics & Gynaecology 2008, 116: 257-267. PMID: 18947340, PMCID: PMC3791329, DOI: 10.1111/j.1471-0528.2008.01925.x.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisCord blood IL-6 levelsBlood IL-6 levelsIntra-amniotic inflammationIL-6 levelsIL-6 ratioFetal inflammatory responseInflammatory statusCord bloodInflammatory responseProteomic biomarkersGestational ageAF IL-6 levelsCord blood IL-6Tertiary referral university hospitalAmniotic fluid biomarkersProspective observational cohortBlood IL-6Neonates of womenInterleukin-6 levelsReferral university hospitalIntra-amniotic infectionEarlier gestational ageDifferential inflammatory responsePositive blood cultures6: Comprehensive proteomic mapping of cord blood to identify novel biomarkers and functional protein networks characteristic of early onset neonatal sepsis (EONS)
Buhimschi C, Bhandari V, Dulay A, Lee S, Zhao G, Pettker C, Abdel-Razeq S, Thung S, Han Y, Buhimschi I. 6: Comprehensive proteomic mapping of cord blood to identify novel biomarkers and functional protein networks characteristic of early onset neonatal sepsis (EONS). American Journal Of Obstetrics And Gynecology 2008, 199: s3. DOI: 10.1016/j.ajog.2008.09.032.Peer-Reviewed Original ResearchFetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation
Buhimschi C, Abdel-Razeq S, Cackovic M, Pettker C, Dulay A, Bahtiyar M, Zambrano E, Martin R, Norwitz E, Bhandari V, Buhimschi I. Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation. American Journal Of Perinatology 2008, 25: 359-372. PMID: 18512201, PMCID: PMC2724874, DOI: 10.1055/s-2008-1078761.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisIntra-amniotic inflammationFetal heart rate monitoring patternsHistological chorioamnionitisPreterm birthPredictive valueAcute histological chorioamnionitisFetuses of womenHuman Development criteriaUseful clinical indicatorNegative predictive valuePositive predictive valueMonitoring patternsNeonatal sepsisPremature neonatesGestational ageLaboratory criteriaAntibiotic treatmentClinical indicatorsChild healthSensitive predictorInflammationAdmissionNeonatesInitial evaluation
2007
199: Early onset neonatal sepsis (EONS): Accompanied by an increased interleukin-6 (IL-6) cytokine index, linked to histological chorioamnionitis
Buhimschi C, Thung S, Bahtiyar M, Rosenberg V, Dulay A, Abdel-Razeq S, Pettker C, Luo G, Zhao G, Sfakianaki A, Lipkind H, Funai E, Bhandari V, Buhimschi I. 199: Early onset neonatal sepsis (EONS): Accompanied by an increased interleukin-6 (IL-6) cytokine index, linked to histological chorioamnionitis. American Journal Of Obstetrics And Gynecology 2007, 197: s67. DOI: 10.1016/j.ajog.2007.10.212.Peer-Reviewed Original ResearchEarly-onset neonatal sepsisOnset neonatal sepsisHistological chorioamnionitisNeonatal sepsisCytokine indexChorioamnionitisSepsis50: Nucleated red blood cells (NRBC) are a direct response to mediators of inflammation in newborns with early onset neonatal sepsis (EONS)
Dulay A, buhimschi I, Zhao G, Luo G, Abdel-Razeq S, Cackovic M, Rosenberg V, Pettker C, Thung S, Bahtiyar M, Bhandari V, Buhimschi C. 50: Nucleated red blood cells (NRBC) are a direct response to mediators of inflammation in newborns with early onset neonatal sepsis (EONS). American Journal Of Obstetrics And Gynecology 2007, 197: s22. DOI: 10.1016/j.ajog.2007.10.056.Peer-Reviewed Original Research
2006
Fetal heart rate monitoring patterns (FHR-MP) to predict early-onset neonatal sepsis in utero in pregnancies complicated by intra-amniotic infection/inflammation
Buhimschi C, Abdel-Razeq S, Pettker C, Cackovic M, Bahtiyar M, Norwitz E, Bhandari V, Buhimschi I. Fetal heart rate monitoring patterns (FHR-MP) to predict early-onset neonatal sepsis in utero in pregnancies complicated by intra-amniotic infection/inflammation. American Journal Of Obstetrics And Gynecology 2006, 195: s224. DOI: 10.1016/j.ajog.2006.10.814.Peer-Reviewed Original Research