2015
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells
Hernandez AL, Kitz A, Wu C, Lowther DE, Rodriguez DM, Vudattu N, Deng S, Herold KC, Kuchroo VK, Kleinewietfeld M, Hafler DA. Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells. Journal Of Clinical Investigation 2015, 125: 4212-4222. PMID: 26524592, PMCID: PMC4639983, DOI: 10.1172/jci81151.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsAntibodies, NeutralizingAutoimmunityCD4-Positive T-LymphocytesCells, CulturedCoculture TechniquesColitisCytokinesForkhead Transcription FactorsGene Expression ProfilingGenes, ReporterGraft vs Host DiseaseHeterograftsHumansImmediate-Early ProteinsInflammationInterferon-gammaLeukocytes, MononuclearMaleMiceProtein Serine-Threonine KinasesRNA InterferenceRNA, Small InterferingSodium ChlorideSodium Chloride, DietaryT-Lymphocytes, RegulatoryConceptsHigh-salt dietTreg functionIFNγ secretionCD4 effector cellsHuman Treg functionRegulatory T cellsAdoptive transfer modelAnti-IFNγ antibodyHost disease modelType 1 diabetesInduction of proinflammatoryTreg pathwayExperimental colitisXenogeneic graftEffector cellsMultiple sclerosisProinflammatory responseT cellsTregsMurine modelSuppressive activitySuppressive functionSerum/glucocorticoid-regulated kinaseAutoimmunityGlucocorticoid-regulated kinase
2001
Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models
Rothstein D, Livak M, Kishimoto K, Ariyan C, Qian H, Fecteau S, Sho M, Deng S, Zheng X, Sayegh M, Basadonna G. Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models. The Journal Of Immunology 2001, 166: 322-329. PMID: 11123308, DOI: 10.4049/jimmunol.166.1.322.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntibodies, BlockingAntibodies, MonoclonalB-LymphocytesCD40 LigandCD8-Positive T-LymphocytesCell MovementCytokinesDrug Therapy, CombinationGraft SurvivalIslets of Langerhans TransplantationLeukocyte Common AntigensMaleMiceMice, Inbred BALB CMice, Inbred C57BLModels, ImmunologicalMonocytesProtein IsoformsSignal TransductionSkin TransplantationTransplantation ToleranceConceptsCostimulatory blockadeCD40 ligand blockadeStringent transplant modelSkin allograft survivalBlockade of CD28Induction of toleranceTh2 cytokine expressionLong-term engraftmentImmunogenic allograftAllograft survivalAllograft toleranceAllograft rejectionC57BL/6 recipientsCD8 cellsIslet allograftsTh1 cytokinesTransplant modelCostimulatory pathwayCytokine expressionCD40 ligandMurine modelB cellsTerm engraftmentBlockadeEngraftment