2011
Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice
Wang Y, Camirand G, Lin Y, Froicu M, Deng S, Shlomchik WD, Lakkis FG, Rothstein DM. Regulatory T Cells Require Mammalian Target of Rapamycin Signaling To Maintain Both Homeostasis and Alloantigen-Driven Proliferation in Lymphocyte-Replete Mice. The Journal Of Immunology 2011, 186: 2809-2818. PMID: 21270412, PMCID: PMC5584652, DOI: 10.4049/jimmunol.0903805.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCell SurvivalGene Knock-In TechniquesHomeostasisIsoantigensLymphocyte ActivationLymphocyte CountLymphocyte DepletionLymphoid TissueMiceMice, Inbred BALB CMice, Inbred C57BLSignal TransductionSirolimusSkin TransplantationT-Lymphocytes, RegulatoryTOR Serine-Threonine KinasesConceptsPercent of TregRegulatory T cellsHost disease modelT cellsTolerogenic agentsMammalian targetConversion of TregsEffect of RapaFoxp3(-) T cellsNumber of TregsSolid organ transplantationDisease modelsAlloantigen-induced proliferationWild-type miceRAPA therapyTreg depletionTreg survivalCD4 cellsLymphopenic hostsImmunosuppressive drugsTregsOrgan transplantationAnimal modelsBaseline numberTconv
2006
Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo
Salvalaggio PR, Camirand G, Ariyan CE, Deng S, Rogozinski L, Basadonna GP, Rothstein DM. Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo. The Journal Of Immunology 2006, 176: 2292-2298. PMID: 16455985, DOI: 10.4049/jimmunol.176.4.2292.Peer-Reviewed Original ResearchConceptsCTLA-4 expressionLong-term engraftmentBALB/cCTLA-4Allograft toleranceCD4 cellsAnti-CD45RB treatmentAcute rejectionCD25 depletionDonor AgUnrelated alloantigensPeritransplant periodAntigen exposureEffector cellsPoor outcomeUnrelated AgAg exposureTransplantationEngraftmentDay 17Day 0Therapeutic enhancementMiceAlloantigensTemporal relationship