2024
The genetics of severe depression
Franklin C, Achtyes E, Altinay M, Bailey K, Bhati M, Carr B, Conroy S, Husain M, Khurshid K, Lencz T, McDonald W, Mickey B, Murrough J, Nestor S, Nickl-Jockschat T, Nikayin S, Reeves K, Reti I, Selek S, Sanacora G, Trapp N, Viswanath B, Wright J, Sullivan P, Zandi P, Potash J. The genetics of severe depression. Molecular Psychiatry 2024, 1-10. PMID: 39406997, DOI: 10.1038/s41380-024-02731-1.Peer-Reviewed Original ResearchGenome-wide association studiesSevere depressionGenome-wide significant lociWhole-exome sequencing studiesAssociated with dysphoriaGenome-wide lociGenome-wide interrogationExome sequencing studiesEarly-onset illnessDegree of impairmentDepressive disorderMDD phenotypesSignificant lociAssociation studiesClinical markers of severitySequencing studiesMDDLociRare variantsClinically actionable findingsEstimates of heritabilityDepressionFamily-basedSevere formGenetics
2021
Evaluating the Role of Ketamine/Esketamine in the Management of Major Depressive Disorder with Suicide Risk
Nikayin S, Sanacora G. Evaluating the Role of Ketamine/Esketamine in the Management of Major Depressive Disorder with Suicide Risk. CNS Drugs 2021, 35: 1069-1079. PMID: 34491545, DOI: 10.1007/s40263-021-00851-8.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDepressive disorderSuicidal ideationFirst large-scale trialKetamine/esketamineTreatment of patientsRole of ketamineSerious suicidal thoughtsActive suicidal ideationLarge-scale trialsAcute settingImminent riskClinical trialsPivotal studiesEsketamineClinical meaningfulnessRecent approvalPatientsSuicidal thoughtsSuicide riskNovel therapeuticsDisordersTrialsDepressed individualsIdeation