2020
Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA
Yuan S, Peng L, Park JJ, Hu Y, Devarkar SC, Dong MB, Shen Q, Wu S, Chen S, Lomakin IB, Xiong Y. Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA. Molecular Cell 2020, 80: 1055-1066.e6. PMID: 33188728, PMCID: PMC7833686, DOI: 10.1016/j.molcel.2020.10.034.Peer-Reviewed Original ResearchConceptsInternal ribosome entry site RNANonstructural protein 1Host protein synthesis machineryMRNA entry channelProtein synthesis machineryCryo-EM structureProtein 1Major pathogenicity factorsDifferential expression analysisMRNA-seq dataCellular transcriptomePreinitiation complexSynthesis machineryHuman lung originTranslation inhibitionPathogenicity factorsExpression analysisSite RNAHost viabilityNSP1Protein synthesisEntry channelViral proteinsUnknown mechanismViral RNA
2003
RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong
Chen X, Feng Q, Wu Z, Liu Y, Huang K, Shi R, Chen S, Lu W, Ding M, Collins R, Fung Y, Lau L, Yu A, Chen J. RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong. Biochemical And Biophysical Research Communications 2003, 308: 899-905. PMID: 12927804, DOI: 10.1016/s0006-291x(03)01511-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsAmino Acid SequenceBase SequenceCloning, MolecularConserved SequenceDNA-Directed RNA PolymerasesFoot-and-Mouth Disease VirusGenetic VariationHong KongModels, GeneticMolecular Sequence DataMutationPhylogenyProtein Structure, TertiaryReverse Transcriptase Polymerase Chain ReactionRNA-Dependent RNA PolymeraseRNA, ViralSequence Analysis, DNASequence Homology, Amino AcidConceptsRNA-dependent RNA polymerase gene sequencesNucleotide sequenceRNA polymerase gene sequencesViral RNA-dependent RNA polymeraseRNA-dependent RNA polymeraseAmino acid sequenceAmino acid residuesMouth disease virusPolymerase gene sequencesCommon ancestorEvolutionary treeRNA polymeraseGene sequencesSequence comparisonAcid sequenceSame geneN-terminusDisease virusAcid residuesGenesFunctional relevanceRepresentative isolatesHost immune systemFMDV isolatesHKN/2002