2022
Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species
Peng L, Fang Z, Renauer PA, McNamara A, Park JJ, Lin Q, Zhou X, Dong MB, Zhu B, Zhao H, Wilen CB, Chen S. Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species. Cell Reports 2022, 40: 111160. PMID: 35921835, PMCID: PMC9294034, DOI: 10.1016/j.celrep.2022.111160.Peer-Reviewed Original ResearchConceptsAntibody responseCoronavirus speciesSequential vaccinationSARS-CoVAntigen-specific antibody responsesSARS-CoV-2 DeltaAdaptive immune cellsEffective immune responsePotent antibody responsesCOVID-19 vaccineSARS-CoV-2MRNA vaccine candidatesActivated B cellsSingle-cell RNA sequencing profilesRNA sequencing profilesSimultaneous vaccinationAntibody immunityVaccination scheduleImmune profileImmune cellsImmune responseVaccine candidatesMERS-CoV.Animal modelsB cells
2021
Metaviromic identification of discriminative genomic features in SARS-CoV-2 using machine learning
Park JJ, Chen S. Metaviromic identification of discriminative genomic features in SARS-CoV-2 using machine learning. Patterns 2021, 3: 100407. PMID: 34812427, PMCID: PMC8598947, DOI: 10.1016/j.patter.2021.100407.Peer-Reviewed Original ResearchAmino acid resolutionSARS-CoV-2 genomeGenomic featuresGenetic elementsCoronavirus genomeGenomeFunctional studiesSequence targetsGenomic profilesUnbiased collectionMajor threatPathogenic virusesUnappreciated featureAnimal originInterpretable signaturesRapid characterizationPathogenic regionsSARS-CoVB cellsSystematic mapRdRpNucleotidesEpitope predictionProteinPathogenicity