2017
Diverse Class 2 CRISPR-Cas Effector Proteins for Genome Engineering Applications
Pyzocha NK, Chen S. Diverse Class 2 CRISPR-Cas Effector Proteins for Genome Engineering Applications. ACS Chemical Biology 2017, 13: 347-356. PMID: 29121460, PMCID: PMC6768076, DOI: 10.1021/acschembio.7b00800.Peer-Reviewed Original ResearchConceptsGenome engineering applicationsCRISPR-Cas genome editing technologiesMicrobial adaptive immune systemGenome editing technologyEffector enzymeNucleic acid cleavageEditing technologyUnique propertiesModern molecular biologyEngineering applicationsEffector proteinsMammalian cellsMolecular biologyAdaptive immune systemWide diversityTechnologyEnzymeApplicationsFunctionalityAcid cleavageImmune systemBiologyProteinDNADiversity
2013
New Gene Evolution: Little Did We Know
Long M, VanKuren NW, Chen S, Vibranovski MD. New Gene Evolution: Little Did We Know. Annual Review Of Genetics 2013, 47: 307-333. PMID: 24050177, PMCID: PMC4281893, DOI: 10.1146/annurev-genet-111212-133301.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDrosophila melanogasterEvolution, MolecularForecastingGene DosageGene DuplicationGene Expression RegulationGene Regulatory NetworksGene Transfer, HorizontalGenesGenes, InsectGenes, PlantGenetic StructuresHumansMammalsModels, GeneticPhenotypePhylogenyRecombination, GeneticRNA, UntranslatedSelection, GeneticSex CharacteristicsTranscription, GeneticConceptsNew gene originationNew genesGene originationGenetic systemNew gene evolutionNew gene structuresGene evolutionPhenotypic evolutionGene structureDifferent organismsBiological diversityPhenotypic functionsGenesGenomeOriginationEvolutionDecades of effortOrganismsDiversityComprehensive pictureCritical componentNew genes as drivers of phenotypic evolution
Chen S, Krinsky BH, Long M. New genes as drivers of phenotypic evolution. Nature Reviews Genetics 2013, 14: 645-660. PMID: 23949544, PMCID: PMC4236023, DOI: 10.1038/nrg3521.Peer-Reviewed Original ResearchConceptsNew genesPhenotypic evolutionLineage-specific essential genesBiological processesUnexpected genetic diversityEvolution of phenotypesFundamental biological processesGene evolutionGenetic circuitryDrosophila sppEssential genesField of geneticsGenetic diversityGenetic systemBiological diversityMolecular explanationGenesIndispensable roleKey PointsThe studySpeciesDiversityEssential componentEvolutionMammalsCentral importance