Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids
K. D, Li Z, Lu AY, Sun F, Chen S, Rothe M, Menzel R, Sun F, Horvitz HR. Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids. Cell 2015, 161: 1152-1163. PMID: 25981666, PMCID: PMC4441829, DOI: 10.1016/j.cell.2015.04.026.Peer-Reviewed Original ResearchConceptsHigh-resolution crystal structuresMembrane fluidityFatty acidsHeat adaptationNuclear hormone receptorsFat-7Lipid desaturationMolecular basisTemperature shiftFatty acid oxidationDesaturase levelsForms of lifeFundamental processesHormone receptorsAcid oxidationUnprecedented modeExpressionCommon inherited disorderAdaptationEukaryotesCaenorhabditisInherited disorderAcidCrystal structureRegulation