CTHRC1+ fibroblasts and SPP1+ macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma
Li E, Cheung H, Ma S. CTHRC1+ fibroblasts and SPP1+ macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma. Scientific Reports 2024, 14: 17412. PMID: 39075108, PMCID: PMC11286765, DOI: 10.1038/s41598-024-68109-z.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaTumor-associated macrophagesTumor microenvironmentEpithelial mesenchymal transitionDuctal adenocarcinomaImmune-suppressive tumor microenvironmentPro-tumorigenic tumor microenvironmentPancreatic cancer casesHeterogeneous tumor microenvironmentCombination of single-cellCancer-associated myofibroblastsSurgical resectionMyeloid cellsCurrent therapiesCancer casesLethal cancersSurvival rateExtracellular matrixTreat cancerMesenchymal transitionTherapeutic targetAdenocarcinomaCellular populationsCancerIntercellular interactionsHEARTSVG: a fast and accurate method for identifying spatially variable genes in large-scale spatial transcriptomics
Yuan X, Ma Y, Gao R, Cui S, Wang Y, Fa B, Ma S, Wei T, Ma S, Yu Z. HEARTSVG: a fast and accurate method for identifying spatially variable genes in large-scale spatial transcriptomics. Nature Communications 2024, 15: 5700. PMID: 38972896, PMCID: PMC11228050, DOI: 10.1038/s41467-024-49846-1.Peer-Reviewed Original ResearchConceptsSpatially variable genesVariable genesSpatial expression patternsSpatial transcriptomics technologiesSpatial transcriptomics researchTranscriptome researchTranscriptomic technologiesBiological functionsExpression patternsSpatial transcriptomicsGenesState-of-the-art methodsColorectal cancer dataInformation‐incorporated sparse hierarchical cancer heterogeneity analysis
Han W, Zhang S, Ma S, Ren M. Information‐incorporated sparse hierarchical cancer heterogeneity analysis. Statistics In Medicine 2024, 43: 2280-2297. PMID: 38553996, DOI: 10.1002/sim.10071.Peer-Reviewed Original ResearchOrganochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study
Rusiecki J, McAdam J, Denic-Roberts H, Sjodin A, Davis M, Jones R, Hoang T, Ward M, Ma S, Zhang Y. Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study. Environmental Health 2024, 23: 28. PMID: 38504322, PMCID: PMC10949709, DOI: 10.1186/s12940-024-01068-0.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancer riskNested case-control studyPapillary thyroid cancerCase-control studyOdds ratioBody mass index categoriesOrganochlorine pesticidesConfidence intervalsFindings of increased riskRisk of papillary thyroid cancerConditional logistic regressionPre-diagnostic serum samplesIndividually-matched controlsThyroid cancerFollicular variant papillary thyroid cancerSerum concentrationsVariant papillary thyroid cancerEffect modificationU.S. military personnelBirth cohortPapillary thyroid cancer casesBirth yearIndex categoriesDecreased riskEffects of organochlorine pesticidesEndocrine disrupting chemical mixture exposure and risk of papillary thyroid cancer in U.S. military personnel: A nested case-control study
Denic-Roberts H, McAdam J, Sjodin A, Davis M, Jones R, Ward M, Hoang T, Ma S, Zhang Y, Rusiecki J. Endocrine disrupting chemical mixture exposure and risk of papillary thyroid cancer in U.S. military personnel: A nested case-control study. The Science Of The Total Environment 2024, 922: 171342. PMID: 38428594, PMCID: PMC11034764, DOI: 10.1016/j.scitotenv.2024.171342.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancer riskEndocrine disrupting chemicalsRisk of papillary thyroid cancerNested case-control studyPolychlorinated biphenylsOne-quartile increaseCase-control studyPapillary thyroid cancerOdds ratioWhite raceEvaluate associationsThyroid cancer riskBrominated flame retardantsEDC mixturesHistological subtypesChemical mixture exposureNon-statistically significant increaseBody mass indexQuantile g-computationOrganochlorine pesticidesSerum sampling timesCancer riskThyroid cancerU.S. military personnelStandard error