2017
Systolic Blood Pressure Response in SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes): A Possible Explanation for Discordant Trial Results
Huang C, Dhruva SS, Coppi AC, Warner F, Li S, Lin H, Nasir K, Krumholz HM. Systolic Blood Pressure Response in SPRINT (Systolic Blood Pressure Intervention Trial) and ACCORD (Action to Control Cardiovascular Risk in Diabetes): A Possible Explanation for Discordant Trial Results. Journal Of The American Heart Association 2017, 6: e007509. PMID: 29133522, PMCID: PMC5721802, DOI: 10.1161/jaha.117.007509.Peer-Reviewed Original ResearchConceptsSystolic blood pressure responseBlood pressure responseTreatment groupsCause deathVisit variabilityDiscordant trialsBlood pressure trialStandard treatment groupPressure responseACCORD participantsPressure trialSBP responseHeart failureMean SBPPrimary outcomeSBPDiscordant resultsMean differenceSimilar interventionsTrial resultsTrialsSimilar mean differencesTreatment effectsSignificant differencesStroke
2010
DNA repair and personalized breast cancer therapy
Li S, Sjolund A, Harris L, Sweasy JB. DNA repair and personalized breast cancer therapy. Environmental And Molecular Mutagenesis 2010, 51: 897-908. PMID: 20872853, PMCID: PMC2962983, DOI: 10.1002/em.20606.Peer-Reviewed Original ResearchConceptsBreast cancer therapyBreast tumor subtypesPersonalized breast cancer therapyTumor subtypesClinical trialsCancer therapyBreast cancer subtypesResponse of tumorsPersonalized cancer therapyChemotherapeutic responseCancer subtypesTherapyChemotherapeutic agentsDNA repair statusRepair statusDNA repair profilesDNA repair deficiencySubtypesRepair deficiencyDrug responseIndividualized mannerTumorsTrialsBiomarkersDNA repair mechanisms