Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia.
Kothapalli R, Bailey R, Kusmartseva I, Mane S, Epling-Burnette P, Loughran T. Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia. International Journal Of Oncology 2003, 22: 33-9. PMID: 12469182, DOI: 10.3892/ijo.22.1.33.Peer-Reviewed Original ResearchMeSH KeywordsCathepsin CCathepsin WCathepsinsCystatin CCystatinsCysteine EndopeptidasesDown-RegulationEndopeptidasesGene Expression Regulation, LeukemicGranzymesHumansLeukemia, LymphoidSerine EndopeptidasesT-Lymphocytes, CytotoxicConceptsRNase protection assaysGene expressionPeripheral blood mononuclear cellsGroup of genesDifferential gene expressionNormal peripheral blood mononuclear cellsBlood mononuclear cellsNorthern blot analysisLGL leukemiaSmall subunitCaspase-8Protein perforinConstitutive expressionMicroarray technologyMononuclear cellsCytotoxic proteasesGenesProtection assaysCysteine proteinasesLarge granular lymphocyte leukemiaBlot analysisLGL leukemia patientsGranular lymphocyte leukemiaAlpha-1 antitrypsinExpression