Infrequent ras activation in chronic myelogenous leukemia (CML): activating 61st codon mutation in the CML-derived cell line, IM-9.
Needleman S, Gutheil J, Kapil V, Mane S. Infrequent ras activation in chronic myelogenous leukemia (CML): activating 61st codon mutation in the CML-derived cell line, IM-9. Leukemia 1989, 3: 827-9. PMID: 2682048.Peer-Reviewed Original ResearchConceptsAcute nonlymphoblastic leukemiaChronic myelogenous leukemiaMyelogenous leukemiaCell linesLymphoblastic cell linesRas gene activationN-rasCML-derived cell linesNonlymphoblastic leukemiaHematopoietic progenitor cellsIM-9LeukemiaProgenitor cellsProto-oncogene cNeoplasmsCodon mutationCell DNAInfrequent eventRas genesc-myc amplification coexistent with activating N-ras point mutation in the biphenotypic leukemic cell line RED-3.
Mallet M, Mane S, Meltzer S, Needleman S. c-myc amplification coexistent with activating N-ras point mutation in the biphenotypic leukemic cell line RED-3. Leukemia 1989, 3: 511-5. PMID: 2659902.Peer-Reviewed Original ResearchConceptsCell linesMYC activationAcute myelogenous leukemiaN-ras point mutationsActivating point mutationC-MycN-rasAML patientsAcute leukemiaHL-60AML cellsMyelogenous leukemiaAggressive acute leukemiasLineage infidelityHuman tumorsDerivative cell linesPoint mutationsPatientsLeukemiaActivationSmall proportionCellsRed 3Protooncogene cMalignancy