Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria
Gandhi S, Baker R, Cho S, Stanchev S, Strisovsky K, Urban S. Designed Parasite-Selective Rhomboid Inhibitors Block Invasion and Clear Blood-Stage Malaria. Cell Chemical Biology 2020, 27: 1410-1424.e6. PMID: 32888502, PMCID: PMC7680425, DOI: 10.1016/j.chembiol.2020.08.011.Peer-Reviewed Original ResearchConceptsRhomboid proteolysisRhomboid intramembrane proteasesAtypical substrate specificityHost cell invasionHigh-resolution structuresRhomboid proteasesIntramembrane proteasesRhomboid inhibitorsSubstrate specificityBlocks invasionRapid invasionDisease contextsSteric clashesProteolysisUltrastructural analysisProteaseInvasionPathophysiological processesPeptide boronatesBlood-stage malariaSteric exclusionParasitesMalaria culturesSequenceTargeting