Featured Publications
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report
Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report. Nature Communications 2022, 13: 1547. PMID: 35301314, PMCID: PMC8930970, DOI: 10.1038/s41467-022-29104-y.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionVirologic responsePersistent SARS-CoV-2 infectionResistance mutationsPre-treatment specimensB-cell deficiencyRemdesivir resistanceRemdesivir therapyViral sheddingCase reportAntiviral agentsPatientsCombinatorial therapyInfectionTherapyWhole-genome sequencingTreatmentImportance of monitoringDe novo emergenceFold increaseRNA-dependent RNA polymeraseNovo emergencePotential benefitsMutationsIndolent
2023
Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC
Dyal J, Gandhi S, Cossaboom C, Leach A, Patel K, Golden M, Canterino J, Landry M, Cannon D, Choi M, Krapiunaya I, Klena J, Shoemaker T. Lymphocytic Choriomeningitis Virus in Person Living with HIV, Connecticut, USA, 2021 - Volume 29, Number 9—September 2023 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2023, 29: 1886-1889. PMID: 37610188, PMCID: PMC10461659, DOI: 10.3201/eid2909.230087.Peer-Reviewed Original Research
2015
A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells
Riestra A, Gandhi S, Sweredoski M, Moradian A, Hess S, Urban S, Johnson P. A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells. PLOS Pathogens 2015, 11: e1005294. PMID: 26684303, PMCID: PMC4684317, DOI: 10.1371/journal.ppat.1005294.Peer-Reviewed Original ResearchConceptsT. vaginalis pathogenesisRhomboid proteasesHost cellsCell surface membrane proteinsIntramembrane serine proteasesDifferent subcellular localizationsSurface membrane proteinsAmino acid residuesSmall amino acidsEukaryotic parasitesTransmembrane domainBioinformatics approachMembrane proteinsSubcellular localizationSurface proteomeSubstrate specificityMolecular mechanismsGolgi apparatusAcid residuesProtease substratesCleavage assaysCleavage siteAmino acidsCell surfaceParasite attachment
2013
Evolution of an Attenuated HIV-1 Isolate in an Elite Suppressor
Salgado M, Gandhi S, Buckheit R, Berkenblit G, Blankson J. Evolution of an Attenuated HIV-1 Isolate in an Elite Suppressor. AIDS Research And Human Retroviruses 2013, 30: 284-288. PMID: 24117037, PMCID: PMC3938915, DOI: 10.1089/aid.2013.0229.Peer-Reviewed Original Research