An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation
Lim C, Gandhi S, Biniossek M, Feng L, Schilling O, Urban S, Chen X. An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation. Cell Reports 2015, 13: 315-325. PMID: 26440886, PMCID: PMC4607668, DOI: 10.1016/j.celrep.2015.09.001.Peer-Reviewed Original ResearchConceptsGermline stem cellsDE-cadherinCell maintenanceTesticular nicheGermline stem cell maintenanceStem cell maintenanceCell dedifferentiationStem cellsAdult stem cellsSpecific aminopeptidase activityMutant phenotypeSpermatogonial DedifferentiationStem cell lossNiche factorsVivo functionExtrinsic cuesNicheAminopeptidase activityDedifferentiationImportant targetCellsMaintenanceOverexpressionMutationsPhenotype