A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells
Riestra A, Gandhi S, Sweredoski M, Moradian A, Hess S, Urban S, Johnson P. A Trichomonas vaginalis Rhomboid Protease and Its Substrate Modulate Parasite Attachment and Cytolysis of Host Cells. PLOS Pathogens 2015, 11: e1005294. PMID: 26684303, PMCID: PMC4684317, DOI: 10.1371/journal.ppat.1005294.Peer-Reviewed Original ResearchConceptsT. vaginalis pathogenesisRhomboid proteasesHost cellsCell surface membrane proteinsIntramembrane serine proteasesDifferent subcellular localizationsSurface membrane proteinsAmino acid residuesSmall amino acidsEukaryotic parasitesTransmembrane domainBioinformatics approachMembrane proteinsSubcellular localizationSurface proteomeSubstrate specificityMolecular mechanismsGolgi apparatusAcid residuesProtease substratesCleavage assaysCleavage siteAmino acidsCell surfaceParasite attachment