2007
Role of APOBEC3G/F-Mediated Hypermutation in the Control of Human Immunodeficiency Virus Type 1 in Elite Suppressors
Gandhi S, Siliciano J, Bailey J, Siliciano R, Blankson J. Role of APOBEC3G/F-Mediated Hypermutation in the Control of Human Immunodeficiency Virus Type 1 in Elite Suppressors. Journal Of Virology 2007, 82: 3125-3130. PMID: 18077705, PMCID: PMC2259015, DOI: 10.1128/jvi.01533-07.Peer-Reviewed Original ResearchConceptsElite suppressorsAntiretroviral therapyHuman immunodeficiency virus type 1 (HIV-1) replicationHIV-1-infected individualsHuman immunodeficiency virus type 1Immunodeficiency virus type 1Control of viremiaActive antiretroviral therapyType 1 replicationVirus type 1Host defense mechanismsViral loadCopies/Clinical significanceAPOBEC3 activityType 1APOBEC3 familyViremiaPatientsTherapyProviral genomeCytidine deaminasesF proteinDefense mechanismsNovel assay
2006
Isolation and Characterization of Replication-Competent Human Immunodeficiency Virus Type 1 from a Subset of Elite Suppressors
Blankson J, Bailey J, Thayil S, Yang H, Lassen K, Lai J, Gandhi S, Siliciano J, Williams T, Siliciano R. Isolation and Characterization of Replication-Competent Human Immunodeficiency Virus Type 1 from a Subset of Elite Suppressors. Journal Of Virology 2006, 81: 2508-2518. PMID: 17151109, PMCID: PMC1865922, DOI: 10.1128/jvi.02165-06.Peer-Reviewed Original ResearchConceptsReplication-competent HIV-1Human immunodeficiency virus type 1Immunodeficiency virus type 1Elite suppressorsVirus type 1HIV-1Replication-Competent Human Immunodeficiency Virus Type 1Untreated human immunodeficiency virus type 1Type 1Active antiretroviral therapyUndetectable viral loadReplication-competent virusAntiretroviral therapyImmunologic controlViral loadCoculture assaysPatientsDefective virusCurrent assaysFull-length sequencingVirusIsolatesAssaysPhenotypic analysisViremia