2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reduction
2014
Factor structure and clinical utility of the Beck Depression Inventory in patients with binge eating disorder and obesity
Udo T, McKee SA, Grilo CM. Factor structure and clinical utility of the Beck Depression Inventory in patients with binge eating disorder and obesity. General Hospital Psychiatry 2014, 37: 120-125. PMID: 25537344, PMCID: PMC4361288, DOI: 10.1016/j.genhosppsych.2014.11.011.Peer-Reviewed Original ResearchConceptsBeck Depression InventoryObese patientsMood disordersClinical utilityDepression InventoryDisorder psychopathologyHigh negative predictive valueMajor depressive disorderNegative predictive valueTreatment-seeking obese patientsExcellent internal consistencyDepressive disorderSelf-report questionnairesDepression symptomsPredictive valuePatientsThree-factor structureScreening instrumentDisordersObesityVariable associationsInternal consistencyHeightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals—Results of a pilot study
Udo T, Weinberger AH, Grilo CM, Brownell KD, DiLeone RJ, Lampert R, Matlin SL, Yanagisawa K, McKee SA. Heightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals—Results of a pilot study. Obesity Research & Clinical Practice 2014, 8: e258-e265. PMID: 24847667, PMCID: PMC4031442, DOI: 10.1016/j.orcp.2013.05.006.Peer-Reviewed Original ResearchConceptsNon-obese individualsHigh-calorie food itemsVagal activityObese individualsHF-HRVHigh-frequency heart rate variabilityHeart rate variabilityConsumption of foodPalatable foodFood itemsAppetitive behaviorCue reactivityPilot studyFood presentationRate variabilityFood cuesFood deprivationObesePotential roleMood statesHRVFurther investigationPresentationInductionMood inductionMenopause and metabolic syndrome in obese individuals with binge eating disorder
Udo T, McKee SA, White MA, Masheb RM, Barnes RD, Grilo CM. Menopause and metabolic syndrome in obese individuals with binge eating disorder. Eating Behaviors 2014, 15: 182-185. PMID: 24854801, PMCID: PMC4032475, DOI: 10.1016/j.eatbeh.2014.01.003.Peer-Reviewed Original ResearchConceptsAge-matched menPostmenopausal womenPremenopausal womenMetabolic syndromeMetabolic abnormalitiesPoor glycemic controlElevated total cholesterolLow HDL levelsChronic medical conditionsHigh-risk populationSymptoms of BEDMetabolic functionsObese menObese womenBlood pressureGlycemic controlTotal cholesterolHDL levelsObese individualsMenopausal transitionGlucose levelsMedical conditionsEarly interventionTreatment studiesElevated levels
2013
The factor structure of the metabolic syndrome in obese individuals with binge eating disorder
Udo T, McKee SA, White MA, Masheb RM, Barnes RD, Grilo CM. The factor structure of the metabolic syndrome in obese individuals with binge eating disorder. Journal Of Psychosomatic Research 2013, 76: 152-157. PMID: 24439692, PMCID: PMC3953028, DOI: 10.1016/j.jpsychores.2013.10.007.Peer-Reviewed Original ResearchConceptsObese individualsMetabolic syndromeMetabolic measuresHigh-risk populationType II diabetesBlood pressurePatient groupExcess weightSubgroup analysisCardiovascular diseaseRisk populationsGlucose regulationTreatment studiesVARCLUS procedurePopulation studiesFactor structureSyndromeBingeDisordersMetSDiverse populationsFour-factor structureIndividualsStatistical Analysis SystemObesitySex differences in biopsychosocial correlates of binge eating disorder: a study of treatment-seeking obese adults in primary care setting
Udo T, McKee SA, White MA, Masheb RM, Barnes RD, Grilo CM. Sex differences in biopsychosocial correlates of binge eating disorder: a study of treatment-seeking obese adults in primary care setting. General Hospital Psychiatry 2013, 35: 587-591. PMID: 23969142, PMCID: PMC3845204, DOI: 10.1016/j.genhosppsych.2013.07.010.Peer-Reviewed Original ResearchConceptsPrimary care settingBiopsychosocial correlatesTreatment-seeking obese patientsPsychosocial factorsSex differencesCare settingsObese menObese adultsClinical studiesFrequent strenuous exercisePsychological impairmentDisorder featuresOnset of overweightCommunity-based studySignificant sex differencesDevelopmental historyTreatment studiesObese patientsBlood pressureMetabolic syndromeBingePrimary careStrenuous exerciseActive screeningGlucose levels
2012
Modeling the effects of positive and negative mood on the ability to resist eating in obese and non-obese individuals
Udo T, Grilo CM, Brownell KD, Weinberger AH, DiLeone RJ, McKee SA. Modeling the effects of positive and negative mood on the ability to resist eating in obese and non-obese individuals. Eating Behaviors 2012, 14: 40-46. PMID: 23265400, PMCID: PMC3633072, DOI: 10.1016/j.eatbeh.2012.10.010.Peer-Reviewed Original ResearchDoes co-morbid depression alter the inverse relationship between obesity and substance use disorders?
Gearhardt AN, Harrison EL, McKee SA. Does co-morbid depression alter the inverse relationship between obesity and substance use disorders? Drug And Alcohol Dependence 2012, 124: 185-188. PMID: 22285319, PMCID: PMC3359394, DOI: 10.1016/j.drugalcdep.2012.01.002.Peer-Reviewed Original ResearchConceptsSubstance use disordersCo-morbid depressionDrug use disordersUse disordersRisk factorsMajor depressionOverweight/obesity statusCommon risk factorsInverse relationshipNormal weightObesity statusExcess food consumptionPsychiatric disordersDepression disorderObesityDrug useReward circuitryU.S. adultsSubstance useDisordersDepressionAdultsFood consumptionRepresentative sampleCurrent study