2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reduction
2007
Naltrexone and Cognitive Behavioral Coping Skills Therapy for the Treatment of Alcohol Drinking and Eating Disorder Features in Alcohol‐Dependent Women: A Randomized Controlled Trial
O'Malley SS, Sinha R, Grilo CM, Capone C, Farren CK, McKee SA, Rounsaville BJ, Wu R. Naltrexone and Cognitive Behavioral Coping Skills Therapy for the Treatment of Alcohol Drinking and Eating Disorder Features in Alcohol‐Dependent Women: A Randomized Controlled Trial. Alcohol Clinical And Experimental Research 2007, 31: 625-634. PMID: 17374042, DOI: 10.1111/j.1530-0277.2007.00347.x.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAlcohol DrinkingAlcoholismAttitudeBody Mass IndexBulimiaCognitive Behavioral TherapyCombined Modality TherapyDepressionFeeding and Eating DisordersFemaleGamma-GlutamyltransferaseHumansNaltrexoneNarcotic AntagonistsPsychiatric Status Rating ScalesTreatment OutcomeConceptsCognitive Behavioral Coping Skills TherapyAlcohol-dependent womenEfficacy of naltrexoneCoping skills therapyAlcohol dependenceOutpatient research clinicSkills therapyCo-occurring psychiatric conditionsEating Disorder FeaturesDSM-IV criteriaPercentage of participantsPrimary outcomeControlled TrialsAlcohol drinkingMedication conditionResearch clinicNaltrexonePsychiatric conditionsSecondary analysisImportant gender differencesTotal abstinenceHeavy drinkingPathologyWomenDrinking outcomes