2019
Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine
Lee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR. Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine. Genes Brain & Behavior 2019, 19: e12601. PMID: 31364813, PMCID: PMC8045136, DOI: 10.1111/gbb.12601.Peer-Reviewed Original ResearchConceptsStress-induced reinstatementEffects of guanfacinePlace preferenceFemale miceInfralimbic cortexArc immunoreactivityΑ2-adrenergic receptor agonistAnterior insulaNeurobiological mechanismsLateral central amygdalaNovel treatment optionsChamber preferencePlace preference acquisitionSex-dependent changesStress-induced relapseDose-response patternNucleus accumbens coreNicotine-dependent behaviorsSmoking occursTreatment optionsNicotine rewardReceptor agonistCentral amygdalaNeuronal activationPreclinical studies
2018
A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco‐deprived and ‐satiated smokers
Roberts W, Verplaetse TL, Moore KE, Oberleitner LM, McKee SA. A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco‐deprived and ‐satiated smokers. Human Psychopharmacology Clinical And Experimental 2018, 33: e2660. PMID: 29878501, PMCID: PMC5995328, DOI: 10.1002/hup.2660.Peer-Reviewed Original ResearchConceptsContinuous performance taskInhibitory controlCognitive functioningPerformance taskTobacco withdrawalEffects of doxazosinSustained attentionCognitive performanceWithdrawal symptomsCognitive AssessmentSmoking outcomesMost measuresSelf-reported withdrawal symptomsReaction timeTaskParticipantsFunctioningPredrug levelsΑ1 antagonistTitration periodGreater improvementDoxazosinSmokingSymptomsPreliminary investigation
2017
Network Analysis of Intrinsic Functional Brain Connectivity in Male and Female Adult Smokers: A Preliminary Study
Maria M, Vanderweyen D, Camp C, Zhu X, McKee SA, Cosgrove KP, Hartwell KJ, Brady KT, Joseph JE. Network Analysis of Intrinsic Functional Brain Connectivity in Male and Female Adult Smokers: A Preliminary Study. Nicotine & Tobacco Research 2017, 20: 810-818. PMID: 29059410, PMCID: PMC5991199, DOI: 10.1093/ntr/ntx206.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNerve NetReinforcement, PsychologySex CharacteristicsSmokersSmokingTobacco Use DisorderConceptsFemale smokersMale smokersAdult smokersNicotine dependenceSalience network regionsIntrinsic functional brain connectivityFemale adult smokersHigh nicotine dependenceEffects of nicotineAge-matched controlsGraph theory measuresFunctional brain connectivityIntrinsic functional connectivitySex differencesSmoking interventionsNucleus accumbensRight insulaSmokersBrain network communicationFunctional connectivityBrain connectivityBlood oxygenFunctional magnetic resonance imaging (fMRI) experimentsConnector hubsBrain networks
2015
Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample
Lewis AS, Oberleitner LM, Morgan PT, Picciotto MR, McKee SA. Association of Cigarette Smoking With Interpersonal and Self-Directed Violence in a Large Community-Based Sample. Nicotine & Tobacco Research 2015, 18: 1456-1462. PMID: 26718905, PMCID: PMC5942535, DOI: 10.1093/ntr/ntv287.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol-Related DisordersCigarette SmokingCross-Sectional StudiesFemaleHumansMaleMiddle AgedRisk FactorsTobacco Use DisorderViolenceConceptsCigarette smoking statusSmoking statusCigarette smokingSelf-directed violenceRisk factorsDaily smokersViolence risk assessmentWave 1Substance useFormer cigarette smokersFormer daily smokersDaily cigarette smokingMajor risk factorNational Epidemiological SurveyCommunity-based sampleLogistic regression modelsRelevant demographic covariatesViolence risk factorsCessation strategiesCigarette smokersPsychiatric diagnosisEpidemiological surveySmokersSmokingAdult subjectsThe Yale Craving Scale: Development and psychometric properties
Rojewski AM, Morean ME, Toll BA, McKee SA, Krishnan-Sarin S, Green BG, Bartoshuk LM, O’Malley S. The Yale Craving Scale: Development and psychometric properties. Drug And Alcohol Dependence 2015, 154: 158-166. PMID: 26183404, PMCID: PMC4834029, DOI: 10.1016/j.drugalcdep.2015.06.040.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCravingFamily HealthFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesPsychometricsTobacco Use DisorderConceptsCeiling effectsPsychometric evaluationCraving ScaleDrinking scoresTreatment-seeking smokersInternal consistencyGood internal consistencyHeavy drinkersSmokingGroup comparisonsDrinking urgesStudy sampleDrinking outcomesSensation intensitySubjective cravingLabeled Magnitude ScaleCigarettesPsychometric propertiesScoresCurrent studyLatent factor structureTest-criterion relationshipsSound scaleSmokersDependent populationThe Relationship Between Childhood Physical and Emotional Abuse and Smoking Cessation Among U.S. Women and Men
Smith PH, Saddleson ML, Homish GG, McKee SA, Kozlowski LT, Giovino GA. The Relationship Between Childhood Physical and Emotional Abuse and Smoking Cessation Among U.S. Women and Men. Psychology Of Addictive Behaviors 2015, 29: 338-346. PMID: 25347015, PMCID: PMC4486346, DOI: 10.1037/adb0000033.Peer-Reviewed Original ResearchConceptsSerious psychological distressChildhood maltreatmentQuit attemptsActual quit attemptsCurrent cigarette smokersSuccessful quit attemptsU.S. adult smokersNational U.S. sampleLikelihood of smokingFemale smokersPsychological distressSmoking cessationCigarette smokersAdult smokersSmoking outcomesSmokingMore difficultyMaltreatmentSmokersU.S. sampleLower likelihoodTelephone surveyPath modelingMotivationWomenA Randomized Trial for Hazardous Drinking and Smoking Cessation for Callers to a Quitline
Toll BA, Martino S, O’Malley S, Fucito LM, McKee SA, Kahler CW, Rojewski AM, Mahoney MC, Wu R, Celestino P, Seshadri S, Koutsky J, Hyland A, Cummings KM. A Randomized Trial for Hazardous Drinking and Smoking Cessation for Callers to a Quitline. Journal Of Consulting And Clinical Psychology 2015, 83: 445-454. PMID: 25419583, PMCID: PMC5996380, DOI: 10.1037/a0038183.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCounselingFemaleHotlinesHumansMaleMiddle AgedNew YorkSmokingSmoking CessationTobacco Use DisorderTreatment OutcomeConceptsStandard careHazardous drinkingHigher smoking cessation ratesNew York State Smokers' QuitlineHeavy drinkingBrief motivational counselingSmoking cessation ratesState Smokers' QuitlineBrief alcohol interventionTelephone coachesCessation counselingTreat analysisCessation ratesRandomized trialsTelephone quitlinesCessation successSmoking cessationAcceptable adherenceMotivational counselingQuitlineAlcohol interventionsAlcohol useCareSmokersDrinking
2014
What is the evidence for hardening in the cigarette smoking population? Trends in nicotine dependence in the U.S., 2002–2012
Smith PH, Rose JS, Mazure CM, Giovino GA, McKee SA. What is the evidence for hardening in the cigarette smoking population? Trends in nicotine dependence in the U.S., 2002–2012. Drug And Alcohol Dependence 2014, 142: 333-340. PMID: 25064023, PMCID: PMC4158455, DOI: 10.1016/j.drugalcdep.2014.07.003.Peer-Reviewed Original ResearchConceptsLow-income smokersNicotine dependenceCigarette smoking populationMiddle-aged smokersDependence severitySerious psychological distressNicotine dependence severitySocio-demographic factorsCurrent smokersCigarette smokingSmoking populationSmokersTobacco consumptionGreater severityDrug useSmokingStudy periodPsychological distressSeverityNational surveyWomenAcute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task
Kahler CW, Metrik J, Spillane NS, Day A, Leventhal AM, McKee SA, Tidey JW, McGeary JE, Knopik VS, Rohsenow DJ. Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task. Psychopharmacology 2014, 231: 4649-4657. PMID: 24858377, PMCID: PMC4232980, DOI: 10.1007/s00213-014-3613-3.Peer-Reviewed Original ResearchConceptsHigh-dose alcoholAlcohol consumptionAcute smoking abstinenceLaboratory analogue taskHeavy alcohol drinkersLow-dose alcoholDose-response effectDose-dependent fashionDose-dependent effectEffect of doseAlcohol drinkersSmoking abstinenceAcute effectsPlacebo beverageSmoking behaviorSmoking urgesSmokingEffect of LowSeparate daysGreater riskLapse behaviorAlcohol effectsPlaceboAbstinenceAlcohol leadSmoking and mental illness in the US population
Smith PH, Mazure CM, McKee SA. Smoking and mental illness in the US population. Tobacco Control 2014, 23: e147. PMID: 24727731, PMCID: PMC4201650, DOI: 10.1136/tobaccocontrol-2013-051466.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleHealth Status DisparitiesHumansLongitudinal StudiesMaleMental DisordersMental Health ServicesMiddle AgedPrevalenceSmokingSmoking CessationSocioeconomic FactorsTobacco Use DisorderYoung AdultConceptsPsychiatric diagnosisCessation ratesQuit ratesSpecific diagnosisMental health service useEstimates of smokingHealth service useCurrent psychiatric diagnosisSpecific psychiatric diagnosesNational Epidemiologic SurveyTimes greater oddsPast-year psychiatric diagnosisHeavy smokingPsychiatric comorbiditySmoking ratesTobacco useTreatment useComorbid disordersSmokingGreater prevalenceService useEpidemiologic SurveyGreater oddsCohort surveyUS population
2012
How Can We Use Our Knowledge of Alcohol-Tobacco Interactions to Reduce Alcohol Use?
McKee SA, Weinberger AH. How Can We Use Our Knowledge of Alcohol-Tobacco Interactions to Reduce Alcohol Use? Annual Review Of Clinical Psychology 2012, 9: 649-674. PMID: 23157448, PMCID: PMC3651830, DOI: 10.1146/annurev-clinpsy-050212-185549.Peer-Reviewed Original ResearchSex‐specific differences in GABAA‐benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving
Esterlis I, McKee SA, Kirk K, Lee D, Bois F, Stiklus SM, Seibyl JP, Krishnan‐Sarin S, O'Malley SS, Staley JK, Cosgrove KP. Sex‐specific differences in GABAA‐benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving. Addiction Biology 2012, 18: 370-378. PMID: 22353491, PMCID: PMC3378766, DOI: 10.1111/j.1369-1600.2011.00403.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffective SymptomsAnalysis of VarianceAnimalsBrainFemaleFlumazenilGABA ModulatorsHumansMaleMiddle AgedNicotinePain PerceptionReceptors, GABA-ASex CharacteristicsSmoking CessationSubstance Withdrawal SyndromeTobacco Use DisorderTomography, Emission-Computed, Single-PhotonYoung AdultConceptsMale smokersFemale smokersPain sensitivitySmoking interactionSmoking cravingBrain GABA levelsTobacco smoking behaviorSingle photon emissionPain symptomsLast cigaretteSmoking cessationGABA levelsSex-specific differencesTobacco smokeCigarette cravingNicotine dependenceBenzodiazepine receptorsSmokersSmoking behaviorReceptor availabilityBrain regionsCravingSex-specific regulationSignificant differencesSex differencesSmoking Cue Reactivity in Adult Smokers with and without Depression: A Pilot Study
Weinberger AH, McKee SA, George TP. Smoking Cue Reactivity in Adult Smokers with and without Depression: A Pilot Study. American Journal On Addictions 2012, 21: 136-144. PMID: 22332857, PMCID: PMC3647350, DOI: 10.1111/j.1521-0391.2011.00203.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesCuesDepressive Disorder, MajorFemaleHumansMaleMiddle AgedPilot ProjectsSmokingTobacco Use DisorderConceptsMajor depressive disorderDiagnosis of MDDCue-induced urgesCue reactivityAdult smokersSmoking cuesPast major depressive disorderMDD historyPilot studySmoking cue reactivitySmoking-related behaviorsCurrent depressive symptomsCue-induced cravingPreferred brand cigarettesDepressive disorderDiagnosis groupsSmoking variablesDepressive symptomsCurrent symptomsSmoking behaviorSmoking urgesDepression symptomsSmokersSymptomsUseful procedure
2011
Effects of pregabalin on smoking behavior, withdrawal symptoms, and cognitive performance in smokers
Herman AI, Waters AJ, McKee SA, Sofuoglu M. Effects of pregabalin on smoking behavior, withdrawal symptoms, and cognitive performance in smokers. Psychopharmacology 2011, 220: 611-617. PMID: 21947318, PMCID: PMC3654651, DOI: 10.1007/s00213-011-2507-x.Peer-Reviewed Original ResearchConceptsPregabalin treatmentSmoking behaviorWithdrawal symptomsTreatment periodAd lib smoking behaviorCognitive performanceEffect of pregabalinTobacco withdrawal symptomsDays of treatmentPregabalin effectCrossover studyWashout periodNicotine withdrawalGABA neurotransmissionNicotine rewardSmoking periodTobacco withdrawalAbstinent smokersBrain glutamateClinical studiesNicotine addictionSmokersPregabalinConclusionsThese findingsGABA analoguesBlunted vagal reactivity predicts stress-precipitated tobacco smoking
Ashare RL, Sinha R, Lampert R, Weinberger AH, Anderson GM, Lavery ME, Yanagisawa K, McKee SA. Blunted vagal reactivity predicts stress-precipitated tobacco smoking. Psychopharmacology 2011, 220: 259-268. PMID: 21938416, PMCID: PMC3260347, DOI: 10.1007/s00213-011-2473-3.Peer-Reviewed Original ResearchConceptsAd lib smokingLF/HFVagal reactivityHF-HRVAbstinent smokersVagal toneSmoking behaviorSmoking cessation outcomesHigh-frequency heart rate variabilityHigh-frequency HRVBaseline HF-HRVHeart rate variabilityScript-driven imageryAltered stress responseTobacco smokingAutonomic functionConclusionsThe current findingsCessation outcomesSympathovagal balanceSmokingRate variabilityAutonomic reactivitySmokersRelapseCurrent findingsThe role of smoking expectancies in the relationship between PTSD symptoms and smoking behavior among women exposed to intimate partner violence
Ashare RL, Weinberger AH, McKee SA, Sullivan TP. The role of smoking expectancies in the relationship between PTSD symptoms and smoking behavior among women exposed to intimate partner violence. Addictive Behaviors 2011, 36: 1333-1336. PMID: 21849230, PMCID: PMC3179791, DOI: 10.1016/j.addbeh.2011.07.022.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAffectFemaleHumansNew EnglandSelf ReportSmokingSpouse AbuseStress Disorders, Post-TraumaticTobacco Use DisorderUrban HealthConceptsNicotine dependenceSmoking behaviorPTSD symptomsSmoking expectanciesIPV-exposed womenIntimate partner violencePTSD re-experiencing symptomsPublic health problemPTSD arousal symptomsHigh rateNegative health consequencesTobacco smokingPartner violencePTSD symptom clustersRe-experiencing symptomsHealth problemsSmokingSymptomsSymptom clustersHealth consequencesTreatment developmentCigarettesArousal symptomsWomenLast month
2009
Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study
McKee SA, Weinberger AH, Harrison EL, Coppola S, George TP. Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study. Schizophrenia Research 2009, 115: 317-324. PMID: 19700263, PMCID: PMC2784178, DOI: 10.1016/j.schres.2009.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBehavior, AddictiveDouble-Blind MethodFemaleHumansMaleMecamylamineMiddle AgedNeuropsychological TestsNicotinic AntagonistsReaction TimeSchizophreniaSelf AdministrationSmokingSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderYoung AdultConceptsAd lib smoking behaviorNicotine levelsSmoking behaviorControl smokersSmoking topographyNicotinic receptor antagonist mecamylamineNicotinic acetylcholine receptor antagonistHealthy control smokersHigh-affinity nAChRsIntensity of smokingAd lib smokingEffects of mecamylamineNumber of cigarettesPlacebo-controlled designAcetylcholine receptor antagonistNicotine exposureAntagonist mecamylamineCompensatory smokingReceptor antagonistSmoking intensityMecamylamineSmokersSmokingSchizophreniaPreliminary studyNicotine Deprivation and Trait Impulsivity Affect Smokers' Performance on Cognitive Tasks of Inhibition and Attention
Harrison EL, Coppola S, McKee SA. Nicotine Deprivation and Trait Impulsivity Affect Smokers' Performance on Cognitive Tasks of Inhibition and Attention. Experimental And Clinical Psychopharmacology 2009, 17: 91-98. PMID: 19331485, PMCID: PMC2863308, DOI: 10.1037/a0015657.Peer-Reviewed Original ResearchConceptsCognitive processingNicotine deprivationImpulsive smokersTrait impulsivityGo/No-Go taskBarratt Impulsiveness ScaleCognitive tasksInhibitory controlPerformance decrementsImpulsiveness ScaleTask IISubjects designImpulsivityGreater impairmentDaily smokersReaction timeDeprivation conditionsMixed model regression analysisTaskProcessingRelapse riskImpairmentSignificant deprivationImpulsivenessDeprivationExperimenting and daily smokers: Episodic patterns of alcohol and cigarette use
Harrison EL, Hinson RE, McKee SA. Experimenting and daily smokers: Episodic patterns of alcohol and cigarette use. Addictive Behaviors 2009, 34: 484-486. PMID: 19176271, PMCID: PMC2865434, DOI: 10.1016/j.addbeh.2008.12.013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DrinkingConsumer BehaviorFemaleHumansMaleOntarioSmokingTobacco Use DisorderYoung AdultConceptsCigarette useEpisodic patternPatterns of alcoholBinge levelsConsumption of drinksSmoking historyCigarette smokingTobacco dependenceDaily smokersNicotine dependenceSmoking episodesConcurrent alcoholSmokersSmokingMore drinksAlcohol useGroup differencesDrinksTypical drinkingDrinkingTotal numberHoursSelf-reported pleasureCigarettesCollege-age sample
2008
Developing human laboratory models of smoking lapse behavior for medication screening
McKee SA. Developing human laboratory models of smoking lapse behavior for medication screening. Addiction Biology 2008, 14: 99-107. PMID: 18855800, PMCID: PMC2732001, DOI: 10.1111/j.1369-1600.2008.00135.x.Peer-Reviewed Original ResearchConceptsMedication screeningHuman laboratory modelSmoking behaviorMedication developmentSubsequent ad libitum smokingAd libitum smokingDrug Administration approvalSelf-administration sessionsMedication signalsCessation medicationsLapse behaviorAdministration approvalFirst cigaretteAbstinence outcomesQuit attemptsSmoking relapseUS FoodSmokingSmokersRelapseImportant targetTranslational workCigarettesScreeningMechanistic evaluation