2015
Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence
Verplaetse TL, Weinberger AH, Smith PH, Cosgrove KP, Mineur YS, Picciotto MR, Mazure CM, McKee SA. Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence. Nicotine & Tobacco Research 2015, 17: 486-495. PMID: 25762760, PMCID: PMC4432402, DOI: 10.1093/ntr/ntu280.Peer-Reviewed Original ResearchConceptsSmoking cessationNoradrenergic systemClinical evidenceTobacco dependenceNoradrenergic activityMedication developmentPoor smoking cessation outcomesCause of morbiditySmoking cessation outcomesStress reactivitySex-specific mechanismsLower quit ratesNicotine-related reinforcementCurrent medicationsMedication effectivenessNicotine reinforcementCessation outcomesNoradrenergic agentsQuit ratesTreatment strategiesTobacco useNoradrenergic compoundsSmoking outcomesTreatment developmentWomen
2014
Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking
Wilson SJ, Delgado MR, McKee SA, Grigson PS, MacLean RR, Nichols TT, Henry SL. Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking. Cognitive, Affective, & Behavioral Neuroscience 2014, 14: 1196-1207. PMID: 24777394, PMCID: PMC4213351, DOI: 10.3758/s13415-014-0285-8.Peer-Reviewed Original ResearchConceptsNicotine-deprived smokersIndividual differencesNondrug rewardsMonetary outcomesVentral striatumReward-related brain activityMeaningful individual differencesFunctional magnetic resonance imagingReward-motivated behaviorsLarge individual differencesVentral striatal responsePoor smoking cessation outcomesSmoking cessation outcomesNondrug incentivesReward devaluationNeural responsesStriatal responsesNeurobiological mechanismsBrain activityNeurobiological responsesCessation outcomesRewardMonetary reinforcementIndividual variabilityClinical implications
2006
Modeling the effect of alcohol on smoking lapse behavior
McKee SA, Krishnan-Sarin S, Shi J, Mase T, O’Malley S. Modeling the effect of alcohol on smoking lapse behavior. Psychopharmacology 2006, 189: 201-210. PMID: 17013640, PMCID: PMC2862311, DOI: 10.1007/s00213-006-0551-8.Peer-Reviewed Original ResearchConceptsFirst cigaretteSelf-administration sessionsNovel human laboratory modelPoor smoking cessation outcomesSmoking cessation outcomesSmoking lapse behaviorHuman laboratory modelEffects of alcoholSecondary outcomesAlcohol drinkersLapse behaviorMore cigarettesNicotine withdrawalCessation outcomesRisk factorsDaily smokersSubsequent smokingTobacco cravingPlacebo beverageTobacco relapseSmoking sessionHeavy social drinkersPriming drinkAlcohol consumptionAlcohol use