Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
Cosgrove KP, Esterlis I, McKee S, Bois F, Alagille D, Tamagnan GD, Seibyl JP, Krishnan-Sarin S, Staley JK. Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers. Nicotine & Tobacco Research 2010, 12: 535-539. PMID: 20371741, PMCID: PMC2861889, DOI: 10.1093/ntr/ntq040.Peer-Reviewed Original ResearchConceptsPain sensitivityCold pressor taskTobacco smokersNicotinic acetylcholine receptorsPain toleranceAcute withdrawalSmoking abstinenceOccipital cortexAnterior cingulateAcetylcholine receptorsAbstinent tobacco smokersHuman tobacco smokersTobacco smoking abstinenceTomography brain imagingSingle photon emissionIA SPECTIA-85380Smoking withdrawalAntinociceptive effectPainful stimuliAcute abstinencePercent changeSimilar associationSmokersBrain imaging