2015
Transcranial Direct Current Brain Stimulation Increases Ability to Resist Smoking
Falcone M, Bernardo L, Ashare RL, Hamilton R, Faseyitan O, McKee SA, Loughead J, Lerman C. Transcranial Direct Current Brain Stimulation Increases Ability to Resist Smoking. Brain Stimulation 2015, 9: 191-196. PMID: 26572280, PMCID: PMC4789149, DOI: 10.1016/j.brs.2015.10.004.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationDorsolateral prefrontal cortexLeft dorsolateral prefrontal cortexActive transcranial direct current stimulationMA anodal stimulationAnodal stimulationSmoking cessation treatmentSmoking behavior changeSelf-reported smokingDirect current stimulationSecondary outcomesCessation treatmentWashout periodFirst cigaretteCigarette cravingOvernight abstinenceTDCS sessionsSmoking sessionCigarette consumptionSmokingTherapeutic potentialCurrent stimulationPrefrontal cortexCognitive control circuitsCathodal stimulation
2012
Developing and Validating a Human Laboratory Model to Screen Medications for Smoking Cessation
McKee SA, Weinberger AH, Shi J, Tetrault J, Coppola S. Developing and Validating a Human Laboratory Model to Screen Medications for Smoking Cessation. Nicotine & Tobacco Research 2012, 14: 1362-1371. PMID: 22492085, PMCID: PMC3482010, DOI: 10.1093/ntr/nts090.Peer-Reviewed Original ResearchConceptsSubsequent ad libitum smokingSmoking cessation medicationsAd libitum smokingCessation medicationsNicotine deprivationSmoking cessationNovel smoking cessation medicationsRatings of cravingSmoking lapse behaviorHuman laboratory modelSecondary outcomesClinical efficacyClinical findingsFirst cigaretteMedication effectsSmokingMedication developmentCigarette effectsMedicationsLapse behaviorSmoking lapseTranslational toolScreen medicationsMonetary reinforcementTranslational work
2010
Stress decreases the ability to resist smoking and potentiates smoking intensity and reward
McKee SA, Sinha R, Weinberger AH, Sofuoglu M, Harrison E, Lavery M, Wanzer J. Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. Journal Of Psychopharmacology 2010, 25: 490-502. PMID: 20817750, PMCID: PMC3637660, DOI: 10.1177/0269881110376694.Peer-Reviewed Original ResearchConceptsSelf-administration sessionsFirst cigaretteTobacco cravingNovel human laboratory modelAdrenal (HPA) axis reactivitySmoking lapse behaviorHuman laboratory modelImpact of stressNegative emotionsTobacco relapseDaily smokersSubsequent smokingImagery inductionAxis reactivitySmokingSubjects designSeparate daysPhysiologic reactivityMonetary reinforcementLapse behaviorTopography systemRelapseGreater satisfactionReduced abilityStress inductionNicotine and food deprivation decrease the ability to resist smoking
Leeman RF, O’Malley S, White MA, McKee SA. Nicotine and food deprivation decrease the ability to resist smoking. Psychopharmacology 2010, 212: 25-32. PMID: 20585761, PMCID: PMC3111597, DOI: 10.1007/s00213-010-1902-z.Peer-Reviewed Original ResearchConceptsSubsequent ad libitum smokingNicotine deprivationAd libitum smokingFood deprivationSmoking lapse behaviorSelf-administration periodEffect of foodSmokers' abilityMore cigarettesFirst cigaretteHuman laboratory paradigmDaily smokersTobacco cravingFood intakeCessation failureSmokingConclusionsThese findingsFood cuesMonetary reinforcementCigarettesNicotineSex differencesDeprivationLaboratory sessionsOutcomes
2008
Developing human laboratory models of smoking lapse behavior for medication screening
McKee SA. Developing human laboratory models of smoking lapse behavior for medication screening. Addiction Biology 2008, 14: 99-107. PMID: 18855800, PMCID: PMC2732001, DOI: 10.1111/j.1369-1600.2008.00135.x.Peer-Reviewed Original ResearchConceptsMedication screeningHuman laboratory modelSmoking behaviorMedication developmentSubsequent ad libitum smokingAd libitum smokingDrug Administration approvalSelf-administration sessionsMedication signalsCessation medicationsLapse behaviorAdministration approvalFirst cigaretteAbstinence outcomesQuit attemptsSmoking relapseUS FoodSmokingSmokersRelapseImportant targetTranslational workCigarettesScreeningMechanistic evaluation
2007
Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: A preliminary study
Toll BA, Schepis TS, O’Malley S, McKee SA, Krishnan-Sarin S. Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: A preliminary study. Drug And Alcohol Dependence 2007, 89: 302-305. PMID: 17320313, PMCID: PMC2475673, DOI: 10.1016/j.drugalcdep.2007.01.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectAgedAntidepressive Agents, Second-GenerationBehavior TherapyBupropionCircadian RhythmDelayed-Action PreparationsFemaleHumansMaleMiddle AgedMotivationNicotineOutcome Assessment, Health CarePrognosisSecondary PreventionSmokingSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderConceptsFirst cigaretteSmoking relapseEnd of treatmentCessation treatment outcomeInitial cigaretteWithdrawal symptomsClinical trialsQuit dayTreatment outcomesNovel predictorRelapseCigarettesPreliminary studyTime pointsGreater decreaseCravingSubjective responsesSubjective reactivityDaysFuture studiesSignificant changesWithdrawalPredictorsResponseBupropion
2006
Modeling the effect of alcohol on smoking lapse behavior
McKee SA, Krishnan-Sarin S, Shi J, Mase T, O’Malley S. Modeling the effect of alcohol on smoking lapse behavior. Psychopharmacology 2006, 189: 201-210. PMID: 17013640, PMCID: PMC2862311, DOI: 10.1007/s00213-006-0551-8.Peer-Reviewed Original ResearchConceptsFirst cigaretteSelf-administration sessionsNovel human laboratory modelPoor smoking cessation outcomesSmoking cessation outcomesSmoking lapse behaviorHuman laboratory modelEffects of alcoholSecondary outcomesAlcohol drinkersLapse behaviorMore cigarettesNicotine withdrawalCessation outcomesRisk factorsDaily smokersSubsequent smokingTobacco cravingPlacebo beverageTobacco relapseSmoking sessionHeavy social drinkersPriming drinkAlcohol consumptionAlcohol use