2024
Imaging a putative marker of brain cortisol regulation in alcohol use disorder
Verplaetse T, Hillmer A, Bhatt S, Rusowicz A, Li S, Nabulsi N, Matuskey D, Huang Y, McKee S, Cosgrove K. Imaging a putative marker of brain cortisol regulation in alcohol use disorder. Neurobiology Of Stress 2024, 29: 100609. PMID: 38304303, PMCID: PMC10832501, DOI: 10.1016/j.ynstr.2024.100609.Peer-Reviewed Original ResearchAlcohol use disorderAnterior cingulate cortexDrinking days/weekModerate to severe alcohol use disorderHealthy controlsHypothalamic-pituitary-adrenal (HPA) axisSevere alcohol use disorderPositron emission tomographyHPA axis dysfunctionHPA axis functionRelease of glucocorticoid hormonesAlcohol consumptionAssociated with drinkingVentromedial PFCCingulate cortexHigh-resolution research tomographHPA activityUse disorderDrinking episodesCortisol regulationAxis functionVmPFCPeripheral cortisolBrain availabilityDisordered backgroundThe role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications
Peltier M, Verplaetse T, Altemus M, Zakiniaeiz Y, Ralevski E, Mineur Y, Gueorguieva R, Picciotto M, Cosgrove K, Petrakis I, McKee S. The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications. Frontiers In Neuroendocrinology 2024, 73: 101119. PMID: 38184208, PMCID: PMC11185997, DOI: 10.1016/j.yfrne.2023.101119.Peer-Reviewed Original ResearchPosttraumatic stress disorderAlcohol use disorderStress disorderContext of PTSDPTSD/AUDConcurrent posttraumatic stress disorderUnderlying neurobiological mechanismsUse disordersAlcohol-related variablesNeurobiological mechanismsPTSD diagnosisTreatment developmentTreatment implicationsBody of literatureNovel interventionsClinical literatureRole of neurosteroidsDisordersTreatment outcomesYears of researchAlcohol consumptionExogenous pregnenolonePharmacological treatmentBiological variablesAllopregnanolone
2023
Liquor consumption is associated with other medical conditions in females who consume alcohol
Verplaetse T, Roberts W, Peltier M, Zakiniaeiz Y, Burke C, Pittman B, McKee S. Liquor consumption is associated with other medical conditions in females who consume alcohol. Drug And Alcohol Dependence Reports 2023, 6: 100132. PMID: 36994369, PMCID: PMC10040322, DOI: 10.1016/j.dadr.2023.100132.Peer-Reviewed Original ResearchMedical conditionsOdds of painSelf-reported doctorU.S. National Epidemiologic SurveyExtreme binge drinkingNational Epidemiologic SurveyConsumption of alcoholCardiovascular conditionsClinical careBinge drinkingEpidemiologic SurveyAlcohol consumptionPoor healthRelated conditionsRisky drinkingLiquor consumptionPainAUD statusCancerMalesRespiratoryContent beveragesFemalesHigh alcohol content beverageSex
2022
A novel human laboratory alcohol self-administration paradigm for medication screening: Modeling the ability to resist drinking and heavy drinking
McKee SA, Verplaetse TL. A novel human laboratory alcohol self-administration paradigm for medication screening: Modeling the ability to resist drinking and heavy drinking. Drug And Alcohol Dependence Reports 2022, 4: 100085. PMID: 36120181, PMCID: PMC9481061, DOI: 10.1016/j.dadr.2022.100085.Peer-Reviewed Original ResearchAlcohol use disorderAlcohol self-administration paradigmSelf-administration paradigmHeavy drinkingAlcohol consumptionMore alcoholAd libitum alcohol consumptionBlood alcohol levelsCross-over designPercent of participantsPreferred alcoholic beverageSelf-administration modelAlcoholic beveragesMedication screeningMedication signalsUse disordersAlcohol levelsGreater cravingFirst drinkDrinkingStress imageryParticipants
2021
Risk drinking levels and sex are associated with cancer and liver, respiratory, and other medical conditions
Verplaetse T, Roberts W, Peltier M, Zakiniaeiz Y, Burke C, Moore K, Pittman B, McKee S. Risk drinking levels and sex are associated with cancer and liver, respiratory, and other medical conditions. Drug And Alcohol Dependence Reports 2021, 1: 100007. PMID: 36843909, PMCID: PMC9948833, DOI: 10.1016/j.dadr.2021.100007.Peer-Reviewed Original ResearchRisk drinking levelsMedical conditionsDrinking levelsAlcohol useU.S. National Epidemiologic SurveySignificant medical conditionsHigh-risk drinking levelsAlcohol-related health consequencesNational Epidemiologic SurveyHeavy drinking femalesHeavy alcohol useHigh-risk drinkingRespiratory conditionsClinical careEpidemiologic SurveyAlcohol consumptionFemale abstainersMale abstainersOrgan systemsHealth consequencesRelated conditionsCancerSexHealth risksFemales
2020
A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States
Roberts W, Marotta PL, Verplaetse TL, Peltier MR, Burke C, Ramchandani VA, McKee SA. A prospective study of the association between rate of nicotine metabolism and alcohol use in tobacco users in the United States. Drug And Alcohol Dependence 2020, 216: 108210. PMID: 32805549, PMCID: PMC7609495, DOI: 10.1016/j.drugalcdep.2020.108210.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioRisk factorsAlcohol useTobacco usersNicotine metabolismTrans-3'-HydroxycotinineWave 1Biochemical risk factorsAlcohol consumption amountCurrent tobacco usersNicotine metabolism rateAssociated health outcomesSex differencesAlcohol use outcomesCigarette smokersNicotine exposureProspective studyOdds ratioTobacco useDrinking statusHealth StudyAlcohol consumptionNicotine useMetabolite ratiosHealth outcomesChanges in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation
Peltier MR, Verplaetse TL, Roberts W, Moore K, Burke C, Marotta PL, Phillips S, Smith PH, McKee SA. Changes in excessive alcohol use among older women across the menopausal transition: a longitudinal analysis of the Study of Women’s Health Across the Nation. Biology Of Sex Differences 2020, 11: 37. PMID: 32665024, PMCID: PMC7362573, DOI: 10.1186/s13293-020-00314-7.Peer-Reviewed Original ResearchConceptsMenopausal transitionExcessive alcohol useExcessive drinkingAlcohol useRandom effects logistic regressionAlcohol-related health consequencesSuch health problemsMethodsThe present studyPresent studyConclusionsThe present studyMenopausal transition stageSex-specific factorsHigher testosterone levelsBackgroundRecent dataEstradiol levelsPostmenopausal stageSex hormonesTestosterone levelsHormonal changesOlder womenAlcoholism criteriaAlcohol abuseAlcohol consumptionWomen's healthStudy of womenSex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years
Verplaetse TL, Cosgrove KP, Tanabe J, McKee SA. Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years. Journal Of Neuroscience Research 2020, 99: 309-323. PMID: 32333417, PMCID: PMC7584757, DOI: 10.1002/jnr.24625.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol consumptionNarrative reviewBrain functionAlcohol useRisk of AUDMagnetic resonance imagingPositron emission tomographyDiffusion tensor imagingHigh-risk drinkingFunctional magnetic resonanceImaging outcomesSex/genderProblematic alcohol consumptionUse disordersResonance imagingEmission tomographySex/gender differencesRobust increaseTensor imagingBrain imaging researchRecent neuroimaging literatureWomenEvent-related potentialsNeurobiological underpinnings
2018
Electronic Cigarette Use and Risk of Harmful Alcohol Consumption in the U.S. Population
Roberts W, Moore K, Peltier MR, Verplaetse TL, Oberleitner L, Hacker R, McKee SA. Electronic Cigarette Use and Risk of Harmful Alcohol Consumption in the U.S. Population. Alcohol Clinical And Experimental Research 2018, 42: 2385-2393. PMID: 30222189, PMCID: PMC6286236, DOI: 10.1111/acer.13889.Peer-Reviewed Original ResearchConceptsAlcohol use disorderE-cigarette useHarmful alcohol useE-cigarette usersHarmful alcohol consumptionAlcohol use outcomesElectronic cigarette useCigarette useAlcohol useE-cigarettesUse outcomesNondaily usersUse disordersAlcohol consumptionPast-year e-cigarette useHazardous drinkingAssociated Disabilities Interview ScheduleCigarette/e-cigarette useU.S. populationRelated Conditions Wave IIIDrinking frequencyTobacco cigarette useNational Epidemiologic SurveyBinge drinking frequencyQuantity/frequencyMobile alcohol biosensors and pharmacotherapy development research
Roberts W, McKee SA. Mobile alcohol biosensors and pharmacotherapy development research. Alcohol 2018, 81: 149-160. PMID: 31679765, PMCID: PMC6842067, DOI: 10.1016/j.alcohol.2018.07.012.Peer-Reviewed Original Research
2017
Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms
Roberts W, Verplaetse TL, Moore K, Oberleitner L, Picciotto MR, McKee SA. Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms. Journal Of Psychopharmacology 2017, 31: 906-914. PMID: 28351203, PMCID: PMC5823265, DOI: 10.1177/0269881117699618.Peer-Reviewed Original ResearchConceptsDepressive symptomsAlcohol cravingAlcohol useEffects of vareniclineRole of nAChRsHuman laboratory studiesDSM-IV criteriaSymptoms of depressionAlcohol use disorderLaboratory testing sessionsMore depressive symptomsMedication pretreatmentPlasma levelsPriming doseVareniclineUse disordersTreatment moderatorsAlcohol consumptionDepression symptomsHeavy drinkersAlcohol usersDrinking taskSymptomsLess drinkingDrinkers
2016
Effect of Lowering the Dose of Varenicline on Alcohol Self-administration in Drinkers With Alcohol Use Disorders
Verplaetse TL, Pittman BP, Shi JM, Tetrault JM, Coppola S, McKee SA. Effect of Lowering the Dose of Varenicline on Alcohol Self-administration in Drinkers With Alcohol Use Disorders. Journal Of Addiction Medicine 2016, 10: 166-173. PMID: 27159341, PMCID: PMC4880525, DOI: 10.1097/adm.0000000000000208.Peer-Reviewed Original ResearchConceptsAlcohol use disorderEffects of vareniclineAlcohol consumptionUse disordersVarenicline doseD dosePlasma levelsDose of vareniclineDoses of vareniclineFrequency of insomniaPlacebo-controlled investigationHigher plasma levelsDose of alcoholAlcohol Self-AdministrationSelf-administration periodMedication pretreatmentAdverse eventsEdition criteriaVareniclineLow doseSide effectsAlcohol cravingMeeting criteriaPhysiologic responsesAlcohol-related outcomes
2015
Influence of the A118G Polymorphism of the OPRM1 Gene and Exon 3 VNTR Polymorphism of the DRD4 Gene on Cigarette Craving After Alcohol Administration
Lechner WV, Knopik VS, McGeary JE, Spillane NS, Tidey JW, McKee SA, Metrik J, Leventhal AM, Rohsenow DJ, Kahler CW. Influence of the A118G Polymorphism of the OPRM1 Gene and Exon 3 VNTR Polymorphism of the DRD4 Gene on Cigarette Craving After Alcohol Administration. Nicotine & Tobacco Research 2015, 18: 632-636. PMID: 26092968, PMCID: PMC5896808, DOI: 10.1093/ntr/ntv136.Peer-Reviewed Original ResearchConceptsA118G polymorphismG polymorphismOPRM1 geneAlcohol administrationG carriersG alleleRepeated-measures design studyA118G genotypeG allele carriersDose of alcoholVNTR polymorphismMean age 39.2Greater increaseSmoking cessationAge 39.2Allele carriersCigarette cravingG genotypeHigh doseAlcohol consumptionHeavy drinkersThree-sessionDRD4 geneHeavy drinkingVNTR genotype
2014
Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task
Kahler CW, Metrik J, Spillane NS, Day A, Leventhal AM, McKee SA, Tidey JW, McGeary JE, Knopik VS, Rohsenow DJ. Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task. Psychopharmacology 2014, 231: 4649-4657. PMID: 24858377, PMCID: PMC4232980, DOI: 10.1007/s00213-014-3613-3.Peer-Reviewed Original ResearchConceptsHigh-dose alcoholAlcohol consumptionAcute smoking abstinenceLaboratory analogue taskHeavy alcohol drinkersLow-dose alcoholDose-response effectDose-dependent fashionDose-dependent effectEffect of doseAlcohol drinkersSmoking abstinenceAcute effectsPlacebo beverageSmoking behaviorSmoking urgesSmokingEffect of LowSeparate daysGreater riskLapse behaviorAlcohol effectsPlaceboAbstinenceAlcohol lead
2013
Increased Cigarette Tax is Associated with Reductions in Alcohol Consumption in a Longitudinal U.S. Sample
Young‐Wolff K, Kasza KA, Hyland AJ, McKee SA. Increased Cigarette Tax is Associated with Reductions in Alcohol Consumption in a Longitudinal U.S. Sample. Alcohol Clinical And Experimental Research 2013, 38: 241-248. PMID: 23930623, PMCID: PMC3830619, DOI: 10.1111/acer.12226.Peer-Reviewed Original ResearchConceptsAlcohol consumptionPublic health benefitsInverse associationCigarette taxesLongitudinal U.S. sampleHealth benefitsYoung adult smokersSmoking-related outcomesFrequency of bingeBaseline alcohol consumptionNational Epidemiological SurveyBinge drinking frequencyMale smokersAdult smokersAlcohol consumersStratified analysisCigarette taxationDrinking statusEpidemiological studiesMultiple linear regression analysisHazardous drinkersSmokersEpidemiological surveyHealth behaviorsLinear regression analysisA preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self‐administration
Udo T, Harrison EL, Shi J, Tetrault J, McKee SA. A preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self‐administration. American Journal On Addictions 2013, 22: 590-597. PMID: 24131167, PMCID: PMC3934424, DOI: 10.1111/j.1521-0391.2013.12014.x.Peer-Reviewed Original ResearchConceptsSelf-administration periodNicotine nasal sprayHeavy drinking smokersNasal sprayNicotine patchAlcohol responsesPriming drinkSerum nicotine levelsPlacebo-controlled studyNicotine replacement therapySubjective alcohol responsesPositive subjective responsesNumber of drinksPlacebo administrationReplacement therapyPriming doseSmoking relapseAlcohol consumptionPlacebo conditionPatch applicationNicotine levelsClinical settingPilot studySmokersSubjective responses
2012
Longitudinal Associations Between Smoking Cessation Medications and Alcohol Consumption Among Smokers in the International Tobacco Control Four Country Survey
McKee SA, Young‐Wolff K, Harrison EL, Cummings KM, Borland R, Kahler CW, Fong GT, Hyland A. Longitudinal Associations Between Smoking Cessation Medications and Alcohol Consumption Among Smokers in the International Tobacco Control Four Country Survey. Alcohol Clinical And Experimental Research 2012, 37: 804-810. PMID: 23240586, PMCID: PMC3610791, DOI: 10.1111/acer.12041.Peer-Reviewed Original ResearchConceptsSmoking cessation medicationsCessation medicationsNicotine replacementAlcohol consumptionInternational Tobacco Control Four Country SurveyFour Country SurveyNicotine replacement therapyReduced alcohol consumptionSmoking statusReplacement therapySmoking cessationMedication effectsMedicationsSmoking behaviorEpidemiological investigationsCountry SurveySmokersAvailable evidenceLongitudinal associationsBaseline drinkingEpidemiological sampleFrequent drinkingTelephone surveyVareniclineSmokingTobacco Quitlines Need to Assess and Intervene with Callers' Hazardous Drinking
Toll BA, Cummings KM, O'Malley SS, Carlin‐Menter S, McKee SA, Hyland A, Wu R, Hopkins J, Celestino P. Tobacco Quitlines Need to Assess and Intervene with Callers' Hazardous Drinking. Alcohol Clinical And Experimental Research 2012, 36: 1653-1658. PMID: 22703028, PMCID: PMC3436938, DOI: 10.1111/j.1530-0277.2012.01767.x.Peer-Reviewed Original ResearchConceptsSmoking cessation ratesCessation ratesBrief alcohol interventionHazardous drinkingHigh-risk drinkersQuitline callersTobacco quitlineCessation outcomesNIAAA guidelinesAlcohol interventionsLower smoking cessation ratesModerate alcohol consumptionShort-term followQuarter of smokersHazardous drinking patternsHigh rateSmoking cessationDaily smokersModerate drinkersSmoking relapseHazardous drinkersAlcohol consumptionSmokersDrinking patternsQuitlineSmoke-free bar policies and smokers’ alcohol consumption: Findings from the International Tobacco Control Four Country Survey
Kasza KA, McKee SA, Rivard C, Hyland AJ. Smoke-free bar policies and smokers’ alcohol consumption: Findings from the International Tobacco Control Four Country Survey. Drug And Alcohol Dependence 2012, 126: 240-245. PMID: 22704125, PMCID: PMC3660989, DOI: 10.1016/j.drugalcdep.2012.05.022.Peer-Reviewed Original ResearchConceptsSmoke-free policiesAlcohol consumptionInternational Tobacco Control Four Country SurveyFour Country SurveyBar policiesIndoor smoke-free policiesSecond-hand smokeHeavy smokersCigarette smokingAmount of alcoholHazardous drinkersSmoking bansPotential associationSmall reductionConcurrent useCountry SurveySmokersSmokingDrinking behaviorHealth risksRepresentative sampleHarmful effectsSingular useDrinkers
2010
Quitting smoking and change in alcohol consumption in the International Tobacco Control (ITC) Four Country Survey
Kahler CW, Borland R, Hyland A, McKee SA, O’Connor R, Fong GT, Cummings KM. Quitting smoking and change in alcohol consumption in the International Tobacco Control (ITC) Four Country Survey. Drug And Alcohol Dependence 2010, 110: 101-107. PMID: 20227840, PMCID: PMC2885485, DOI: 10.1016/j.drugalcdep.2010.02.008.Peer-Reviewed Original ResearchConceptsAlcohol consumptionInternational Tobacco Control Four Country SurveySmoking cessationFour Country SurveyAlcohol useHeavy drinkingSustained smoking cessationProspective cohort studyGreater reductionCohort studyHeaviness of smokingFrequent heavy drinkingDecreased oddsQuit attemptsSmokingHazardous drinkingCountry SurveyStudy wavesCessationDrinkingLower ratesAlcohol dataWeekly quantityMeaningful changePresent study