2023
Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury
Wen Y, Su E, Xu L, Menez S, Moledina D, Obeid W, Palevsky P, Mansour S, Devarajan P, Cantley L, Cahan P, Parikh C, Project K, Injury T. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury. Science Translational Medicine 2023, 15: eade7287. PMID: 38091407, DOI: 10.1126/scitranslmed.ade7287.Peer-Reviewed Original ResearchA randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel groupIntegrated Analysis of Blood and Urine Biomarkers to Identify Acute Kidney Injury Subphenotypes and Associations With Long-term Outcomes
Bhatraju P, Prince D, Mansour S, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Kaufman J, Kimmel P, Coca S, Parikh C, Wurfel M, Himmelfarb J. Integrated Analysis of Blood and Urine Biomarkers to Identify Acute Kidney Injury Subphenotypes and Associations With Long-term Outcomes. American Journal Of Kidney Diseases 2023, 82: 311-321.e1. PMID: 37178093, PMCID: PMC10523857, DOI: 10.1053/j.ajkd.2023.01.449.Peer-Reviewed Original ResearchConceptsMajor adverse kidney eventsLong-term outcomesAKI subphenotypesKidney injuryClinical outcomesUrinary biomarkersHigh riskChronic kidney disease progressionLong-term clinical outcomesCox proportional hazards modelAdverse kidney eventsLong-term sequalaeHospital-level factorsKidney disease progressionChronic kidney diseaseKaplan-Meier curvesSerum creatinine concentrationEpithelial cell injuryHeterogeneous clinical syndromeProportional hazards modelLong-term riskAKI patientsAKI subgroupKDIGO stageMedian follow
2022
Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study
Vasquez-Rios G, Moledina D, Jia Y, McArthur E, Mansour S, Thiessen-Philbrook H, Shlipak M, Koyner J, Garg A, Parikh C, Coca S. Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study. Journal Of Cardiothoracic Surgery 2022, 17: 338. PMID: 36567329, PMCID: PMC9790121, DOI: 10.1186/s13019-022-02066-4.Peer-Reviewed Original ResearchConceptsKidney injury molecule-1Cardiovascular eventsCardiac surgeryCKD eventsCohort studyPlasma kidney injury molecule-1Chronic kidney disease (CKD) incidenceKidney disease incidenceKidney function dataPre-operative concentrationsInjury molecule-1Evaluation of patientsHigh-risk adultsLong-term outcomesHigh-risk individualsTumor necrosis factor receptorNecrosis factor receptorKidney eventsMedian followPlasma sTNFR1Hazard ratioClinical outcomesKidney biomarkersPlasma biomarkersClinical covariatesDeceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort
Reese PP, Doshi MD, Hall IE, Besharatian B, Bromberg JS, Thiessen-Philbrook H, Jia Y, Kamoun M, Mansour SG, Akalin E, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Deceased-Donor Acute Kidney Injury and Acute Rejection in Kidney Transplant Recipients: A Multicenter Cohort. American Journal Of Kidney Diseases 2022, 81: 222-231.e1. PMID: 36191727, PMCID: PMC9868058, DOI: 10.1053/j.ajkd.2022.08.011.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibodiesBiopsy-proven acute rejectionAcute kidney injuryNeutrophil gelatinase-associated lipocalinDe novo DSAGraft failurePrimary outcomeAcute rejectionKidney recipientsKidney injurySecondary outcomesAcute Kidney Injury Network criteriaClinical acute kidney injuryNovo donor-specific antibodiesSignificant associationKidney injury molecule-1Recipient alloimmune responsesUrinary IL-18Donor-specific antibodiesFirst posttransplant yearKidney transplant recipientsInjury molecule-1Gelatinase-associated lipocalinDeceased donor kidneysFine-Gray model
2021
Post-transplant Diabetes Mellitus in Kidney Transplant Recipients: A Multicenter Study
Malik RF, Jia Y, Mansour SG, Reese PP, Hall IE, Alasfar S, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Philbrook H, Parikh CR. Post-transplant Diabetes Mellitus in Kidney Transplant Recipients: A Multicenter Study. Kidney360 2021, 2: 1296-1307. PMID: 35369651, PMCID: PMC8676388, DOI: 10.34067/kid.0000862021.Peer-Reviewed Original ResearchConceptsPost-transplant diabetes mellitusKidney Donor Profile IndexGraft failureKidney transplantRecipient ageRisk factorsDevelopment of PTDMDeath-censored graft failureAdult kidney recipientsCause graft failureDocumentation of diabetesMulticenter longitudinal cohortOlder recipient ageYear post-KTKidney transplant recipientsHigher baseline BMIDetailed chart reviewElectronic medical recordsKidney recipientsMaintenance immunosuppressionPost-KTBaseline BMIHCV infectionHLA mismatchesKT recipientsDeceased-Donor Acute Kidney Injury and BK Polyomavirus in Kidney Transplant Recipients
Hall IE, Reese PP, Mansour SG, Mohan S, Jia Y, Thiessen-Philbrook HR, Brennan DC, Doshi MD, Muthukumar T, Akalin E, Harhay MN, Schröppel B, Singh P, Weng FL, Bromberg JS, Parikh CR. Deceased-Donor Acute Kidney Injury and BK Polyomavirus in Kidney Transplant Recipients. Clinical Journal Of The American Society Of Nephrology 2021, 16: 765-775. PMID: 33692117, PMCID: PMC8259491, DOI: 10.2215/cjn.18101120.Peer-Reviewed Original ResearchConceptsDonor AKIBKV DNAemiaGraft failureLower riskOPTN databaseKidney Donor Profile IndexCox proportional hazards modelMean recipient ageAcute kidney injuryAdjusted hazard ratioKidney transplant recipientsTransplantation Network databaseRecipient-related factorsProportional hazards modelIschemia-reperfusion processAllograft failureAllograft integrityKidney recipientsBKV infectionKidney injuryKidney transplantationRecipient ageTransplant recipientsHazard ratioProspective cohortContemporary incidence and risk factors of post transplant Erythrocytosis in deceased donor kidney transplantation
Alasfar S, Hall IE, Mansour SG, Jia Y, Thiessen-Philbrook HR, Weng FL, Singh P, Schröppel B, Muthukumar T, Mohan S, Malik RF, Harhay MN, Doshi MD, Akalin E, Bromberg JS, Brennan DC, Reese PP, Parikh CR. Contemporary incidence and risk factors of post transplant Erythrocytosis in deceased donor kidney transplantation. BMC Nephrology 2021, 22: 26. PMID: 33435916, PMCID: PMC7802150, DOI: 10.1186/s12882-021-02231-2.Peer-Reviewed Original ResearchConceptsKidney Donor Profile IndexRAAS inhibitorsRisk factorsLower kidney donor profile indexDeceased donor kidney transplantationWorld Health Organization criteriaHigh kidney donor profile indexCurrent transplant practiceHigh-quality kidneysPost-transplant erythrocytosisDonor kidney transplantationMajority of patientsLarge recent cohortPolycystic kidney diseaseRisk of PTEsKidney recipientsTransplant erythrocytosisCerebrovascular eventsKidney transplantationPTE patientsConclusionsThe incidenceGraft failureContemporary incidenceDeceased donorsKidney disease
2020
Prediction of outcomes after acute kidney injury in hospitalised patients: protocol for a systematic review
Arora T, Martin M, Grimshaw A, Mansour S, Wilson FP. Prediction of outcomes after acute kidney injury in hospitalised patients: protocol for a systematic review. BMJ Open 2020, 10: e042035. PMID: 33371041, PMCID: PMC7757434, DOI: 10.1136/bmjopen-2020-042035.Peer-Reviewed Original ResearchConceptsAcute kidney injuryPrediction of outcomeSystematic reviewKidney injuryOutcomes of AKIResolution of AKIProgression of AKILong-term outcomesBias assessment toolRisk of biasMultivariable predictive modelMeta-Analyses (PRISMA) guidelinesPreferred Reporting ItemsFull-text reviewPrediction model RiskAKI careCohort studyNegative long-term outcomesThird reviewerReporting ItemsAbstract screeningComprehensive searchPatientsCommon diseaseData extractionUromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes.
Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes. Transplantation 2020, 105: 876-885. PMID: 32769629, PMCID: PMC8805736, DOI: 10.1097/tp.0000000000003299.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBiomarkersCells, CulturedDelayed Graft FunctionFemaleGlomerular Filtration RateGraft SurvivalHistocompatibility Antigens Class IIHumansKidneyKidney TransplantationMacrophagesMaleMiceMiddle AgedOsteopontinProspective StudiesRisk AssessmentRisk FactorsTime FactorsTissue DonorsUnited StatesUromodulinConceptsGraft failureGraft functionGraft outcomePrimary outcomeMajor histocompatibilityDeath-censored graft failureDeceased donor kidney transplantationCause graft failureImproved graft survivalRecipient graft outcomesKidney graft outcomeGlomerular filtration rateDeceased donor kidneysTime of procurementGraft survivalKidney transplantationDirection of associationDeceased donorsFiltration rateKidney qualityLower riskExtensive injuryDonor urineSimilar associationMouse macrophagesResults from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery
Menez S, Moledina DG, Garg AX, Thiessen-Philbrook H, McArthur E, Jia Y, Liu C, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Wilson FP, Coca SG, Parikh CR. Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery. Kidney International 2020, 99: 716-724. PMID: 32721447, PMCID: PMC8077034, DOI: 10.1016/j.kint.2020.06.037.Peer-Reviewed Original ResearchConceptsEstimated glomerular filtration rateChronic kidney diseaseBaseline estimated glomerular filtration rateCardiac surgeryCKD incidenceKidney diseaseBlood biomarkersN-terminal pro-B-type natriuretic peptideDevelopment of CKDPro-B-type natriuretic peptideReplication cohortAcute kidney injury groupLong-term kidney outcomesKidney injury molecule-1Acute kidney injuryPrimary composite outcomeInjury molecule-1Post-operative levelsGlomerular filtration rateTumor necrosis factor receptor 1Necrosis factor receptor 1Basic fibroblast growth factorFactor receptor 1Fibroblast growth factorAKI studiesUrine Injury Biomarkers Are Not Associated With Kidney Transplant Failure.
Koyawala N, Reese PP, Hall IE, Jia Y, Thiessen-Philbrook HR, Mansour SG, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, Weng FL, Parikh CR. Urine Injury Biomarkers Are Not Associated With Kidney Transplant Failure. Transplantation 2020, 104: 1272-1279. PMID: 31568213, PMCID: PMC7384615, DOI: 10.1097/tp.0000000000002948.Peer-Reviewed Original ResearchConceptsAcute kidney injuryDonor Acute Kidney InjuryGraft failureInjury biomarkersSerum creatinineGraft outcomeKidney injuryComposite outcomeDeath-censored graft failureRisk of GFKidney injury molecule-1Cox proportional hazards modelLiver-type fatty acidSimilar allograft survivalStructural kidney damageKidney transplant recipientsInjury molecule-1Kidney transplant failureGlomerular filtration rateProportional hazards modelAKI kidneysAllograft survivalTransplant recipientsChart reviewNeutrophil gelatinaseAssociation of Deceased Donor Acute Kidney Injury With Recipient Graft Survival
Liu C, Hall IE, Mansour S, Philbrook H, Jia Y, Parikh CR. Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival. JAMA Network Open 2020, 3: e1918634. PMID: 31913491, PMCID: PMC6991314, DOI: 10.1001/jamanetworkopen.2019.18634.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryRecipient graft survivalDeath-censored graft failureCause graft failureAKI kidneysDeceased donorsGraft failureGraft survivalOrgan procurement organizationsAKI statusGraft functionKidney injuryPrimary nonfunctionMean agePropensity score-matched cohort studyTerminal serum creatinine levelPropensity score-matched analysisFollowing secondary outcomesDelayed graft functionSerum creatinine levelsProcurement organizationsDeceased donor kidneysDates of analysisAKI stage
2019
The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running
Mansour SG, Martin TG, Obeid W, Pata RW, Myrick KM, Kukova L, Jia Y, Bjornstad P, El-Khoury JM, Parikh CR. The Role of Volume Regulation and Thermoregulation in AKI during Marathon Running. Clinical Journal Of The American Society Of Nephrology 2019, 14: 1297-1305. PMID: 31413064, PMCID: PMC6730516, DOI: 10.2215/cjn.01400219.Peer-Reviewed Original ResearchConceptsCore body temperatureBody temperaturePercent of runnersAcute tubular injuryPlasma copeptin concentrationsMajority of runnersContinuous core body temperatureAKIN criteriaDays postmarathonPrior marathonsTransient AKICopeptin concentrationsTubular injuryInjury biomarkersPrimary outcomeProspective cohortNephron damageNegative sodiumUrine microscopyVolume lossUrine sedimentAKIAbstractTextSweat sodiumCopeptin
2018
Deceased-donor acute kidney injury is not associated with kidney allograft failure
Hall IE, Akalin E, Bromberg JS, Doshi MD, Greene T, Harhay MN, Jia Y, Mansour SG, Mohan S, Muthukumar T, Reese PP, Schröppel B, Singh P, Thiessen-Philbrook HR, Weng FL, Parikh CR. Deceased-donor acute kidney injury is not associated with kidney allograft failure. Kidney International 2018, 95: 199-209. PMID: 30470437, PMCID: PMC6331055, DOI: 10.1016/j.kint.2018.08.047.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryCause graft failureGraft survivalGraft failureGraft functionKidney injuryComposite outcomeDeceased donorsDonor-recipient gender combinationsLong-term allograft survivalKidney Donor Profile IndexDonor AKI stageExpanded-criteria donationKidney allograft failureUtilization of kidneysGlomerular filtration rateCold ischemia timePre-specified variablesKidney machine perfusionAKI stageAllograft failureAllograft survivalCardiac deathIschemia time
2017
Kidney Injury and Repair Biomarkers in Marathon Runners
Mansour SG, Verma G, Pata RW, Martin TG, Perazella MA, Parikh CR. Kidney Injury and Repair Biomarkers in Marathon Runners. American Journal Of Kidney Diseases 2017, 70: 252-261. PMID: 28363731, PMCID: PMC5526736, DOI: 10.1053/j.ajkd.2017.01.045.Peer-Reviewed Original ResearchConceptsCreatinine levelsDay 0Kidney injuryTubular injuryUrine albuminSerum creatinineKidney functionUrine biomarkersBiomarker levelsSerum creatine kinase levelsMarathon runnersAKI Network criteriaAKI stage 1Stage 1 AKISerum creatinine levelsRenal tubular epithelial cellsLimited clinical dataCreatine kinase levelsTubular epithelial cellsDL increaseMean ageMicroscopy scoreGranular castsClinical dataObservational study
2016
Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation
Besse W, Mansour S, Jatwani K, Nast CC, Brewster UC. Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation. BMC Nephrology 2016, 17: 125. PMID: 27600725, PMCID: PMC5013576, DOI: 10.1186/s12882-016-0330-7.Peer-Reviewed Case Reports and Technical NotesConceptsParvovirus B19 infectionAcute parvovirus B19 infectionFocal segmental glomerulosclerosisHuman immunodeficiency virusAPOL1 risk allelesB19 infectionRisk allelesCollapsing variant of focal segmental glomerulosclerosisVariant of focal segmental glomerulosclerosisPublished case reportsHuman immunodeficiency virus (HIV) infectionCaribbean-American womenInfection of podocytesAcute parvovirus infectionImmunodeficiency virus infectionRapid clinical courseFetal demiseForms of FSGSLight microscopy findingsClinical courseHIV-negativeImmunodeficiency virusRenal biopsyKidney biopsyParvovirus B19