2022
Clinically adjudicated deceased donor acute kidney injury and graft outcomes
Mansour SG, Khoury N, Kodali R, Virmani S, Reese PP, Hall IE, Jia Y, Yamamoto Y, Thiessen-Philbrook HR, Obeid W, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Singh P, Weng FL, Moledina DG, Greenberg JH, Wilson FP, Parikh CR. Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLOS ONE 2022, 17: e0264329. PMID: 35239694, PMCID: PMC8893682, DOI: 10.1371/journal.pone.0264329.Peer-Reviewed Original ResearchConceptsDonor Acute Kidney InjuryAcute kidney injuryGraft failureAKI phenotypesKidney injuryUrine biomarkersLack of associationAKI casesGraft functionHigher DGFPotential kidneyGraft outcomeDeceased donorsOrgan utilizationMCP-1YKL-40Donor StudyEGFRDGFAncillary analysisAvailable chartsBiomarkersInjuryPhenotypeAssociation
2021
Urinary EGF and MCP-1 and risk of CKD after cardiac surgery
Menez S, Ju W, Menon R, Moledina DG, Thiessen Philbrook H, McArthur E, Jia Y, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Coca SG, Garg AX, Bomback AS, Kellum JA, Kretzler M, Parikh CR, . Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021, 6: e147464. PMID: 33974569, PMCID: PMC8262289, DOI: 10.1172/jci.insight.147464.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overCardiac Surgical ProceduresChemokine CCL2Disease ProgressionEpidermal Growth FactorFemaleGene Expression ProfilingHumansIncidenceMalePostoperative ComplicationsProportional Hazards ModelsRenal Insufficiency, ChronicRNA, MessengerRNA-SeqSingle-Cell AnalysisConceptsAcute kidney injuryCardiac surgeryMCP-1CKD outcomesUrinary EGFLong-term kidney outcomesChronic kidney disease riskTRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) ConsortiumKidney disease riskMCP-1 levelsRisk of CKDAmerican Heart AssociationPostoperative urine samplesHealth Research InstituteLong-term careCKD incidenceKidney outcomesKidney injuryKidney Precision Medicine ProjectComposite outcomeTubular damageHeart AssociationCCL2 expressionGlomerular functionKidney Center
2017
Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review
Mansour SG, Puthumana J, Coca SG, Gentry M, Parikh CR. Biomarkers for the detection of renal fibrosis and prediction of renal outcomes: a systematic review. BMC Nephrology 2017, 18: 72. PMID: 28219345, PMCID: PMC5319065, DOI: 10.1186/s12882-017-0490-0.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-2Renal outcomesRenal functionRenal fibrosisStage ISystematic reviewWorse renal outcomeChronic kidney diseaseBiomarkers of fibrosisChemoattractant protein-1Diverse patient populationsGrowth factor βUrine biomarkersKidney diseaseMCP-1Patient populationDisease progressionMetalloproteinase-2FibrosisModerate positive correlationStage IIPatientsUnifying pathwayBiomarkersReliability of blood