Shenping Wu
Senior Research Scientist in PharmacologyCards
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Pharmacology
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Senior Research Scientist in Pharmacology
Appointments
Pharmacology
Senior Research ScientistPrimaryMolecular Biophysics and Biochemistry
Research ScientistSecondary
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Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Shenping Wu's published research.
Publications Timeline
A big-picture view of Shenping Wu's research output by year.
Jun Liu, PhD
Elias Lolis, PhD
Jimin Wang, PhD
Victor Batista
22Publications
732Citations
Publications
2022
How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM
Wang J, Liu J, Gisriel CJ, Wu S, Maschietto F, Flesher DA, Lolis E, Lisi GP, Brudvig GW, Xiong Y, Batista VS. How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM. Journal Of Structural Biology 2022, 214: 107902. PMID: 36202310, PMCID: PMC10226527, DOI: 10.1016/j.jsb.2022.107902.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCryo-EM mapsAmino acid residuesAcid residuesCryo-electron microscopy mapIndividual amino acid residuesCyanobacteria Synechocystis spPCC 6803Synechocystis spMicroscopy mapsThermosynechococcus elongatusSARS-CoV-2 spike proteinLocal structural changesResiduesSpike proteinAtomic coordinatesElongatusSubunitsSpeciesProteinSpSimilar structureStructural changes
2019
Structural Studies αvβ8 Integrin by Single Particle Cryo-EM
Campbell M, Cormier A, Ito S, Wu S, Lou J, Marks J, Baron J, Nishimura S, Cheng Y. Structural Studies αvβ8 Integrin by Single Particle Cryo-EM. Microscopy And Microanalysis 2019, 25: 1312-1313. DOI: 10.1017/s1431927619007293.Peer-Reviewed Original ResearchCryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome
Armache J, Gamarra N, Johnson S, Leonard J, Wu S, Narlikar G, Cheng Y. Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome. ELife 2019, 8: e46057. PMID: 31210637, PMCID: PMC6611695, DOI: 10.7554/elife.46057.Peer-Reviewed Original ResearchCitationsAltmetric
2018
Cryo-EM structure of the Mechanotransduction Channel NOMPC
Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan L, Jan Y, Cheng Y. Cryo-EM structure of the Mechanotransduction Channel NOMPC. Biophysical Journal 2018, 114: 22a. DOI: 10.1016/j.bpj.2017.11.164.Peer-Reviewed Original Research
2014
Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter
Kim J, Wu S, Tomasiak T, Mergel C, Winter M, Stiller S, Robles-Colmanares Y, Stroud R, Tampé R, Craik C, Cheng Y. Subnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporter. Nature 2014, 517: 396-400. PMID: 25363761, PMCID: PMC4372080, DOI: 10.1038/nature13872.Peer-Reviewed Original ResearchCitationsAltmetricStructural Studies of the Yeast Prp8-Snu114 Complex
He Y, Wu S, Booth D, Agarrd D, Cheng Y, Guthrie C. Structural Studies of the Yeast Prp8-Snu114 Complex. Biophysical Journal 2014, 106: 47a. DOI: 10.1016/j.bpj.2013.11.338.Peer-Reviewed Original ResearchThe Mechanism of Nucleosome Spacing by a Dimeric Chromatin Remodeling Enzyme
Leonard J, Armache J, Naber N, Wu S, Pate E, Cooke R, Cheng Y, Narlikar G. The Mechanism of Nucleosome Spacing by a Dimeric Chromatin Remodeling Enzyme. Biophysical Journal 2014, 106: 69a-70a. DOI: 10.1016/j.bpj.2013.11.461.Peer-Reviewed Original Research
2013
Mechanistic Analysis of HP1 heterochromatin assembly
Narlikar G, Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Cooke R, Schuck P, Cheng Y. Mechanistic Analysis of HP1 heterochromatin assembly. The FASEB Journal 2013, 27: 456.3-456.3. DOI: 10.1096/fasebj.27.1_supplement.456.3.Peer-Reviewed Original ResearchConceptsHeterochromatin protein 1Form of heterochromatinAuto-inhibited statePost-translation modificationsHP1 proteinsHeterochromatin assemblyHeterochromatin proteinsChromatin complexesLysine 9Adjacent nucleosomesHistone H3Swi6Competent stateMolecular basisChromodomainChromatinEM structuresDiverse interactionsProtein 1NucleosomesBiochemical dataProteinMechanistic analysisTestable hypothesesAssemblyA conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly
Canzio D, Liao M, Naber N, Pate E, Larson A, Wu S, Marina D, Garcia J, Madhani H, Cooke R, Schuck P, Cheng Y, Narlikar G. A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly. Nature 2013, 496: 377-381. PMID: 23485968, PMCID: PMC3907283, DOI: 10.1038/nature12032.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAmino Acid SequenceAnimalsChromatin Assembly and DisassemblyChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneCryoelectron MicroscopyGene SilencingHeterochromatinHistonesMethylationModels, MolecularMolecular Sequence DataNucleosomesProtein Structure, TertiarySchizosaccharomycesSchizosaccharomyces pombe ProteinsXenopus laevis
2012
Electron Tomography of Paracrystalline 2D Arrays
Winkler H, Wu S, Taylor K. Electron Tomography of Paracrystalline 2D Arrays. Methods In Molecular Biology 2012, 955: 427-460. PMID: 23132074, PMCID: PMC7032944, DOI: 10.1007/978-1-62703-176-9_23.Peer-Reviewed Original ResearchCitations
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