Shengtao Yang, PhD
Associate Research Scientist in NeuroscienceCards
About
Research
Publications
2025
Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness
Yang S, Datta D, Krienen F, Woo E, May A, Anderson G, Galvin V, Gonzalez-Burgos G, Lewis D, Ling E, McCarroll S, Arnsten A, Wang M. Kynurenic acid signaling expands in human and nonhuman primates and impairs dorsolateral prefrontal cortical cognition that is key to mental illness. Molecular Psychiatry 2025, 31: 1190-1200. PMID: 41413200, PMCID: PMC12929064, DOI: 10.1038/s41380-025-03425-y.Peer-Reviewed Original ResearchDysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology
Arnsten A, Perone I, Wang M, Yang S, Uchendu S, Bolat D, Datta D. Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer’s disease neuropathology. Frontiers In Aging Neuroscience 2025, 17: 1610350. PMID: 40735190, PMCID: PMC12303958, DOI: 10.3389/fnagi.2025.1610350.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original Researchβ1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2022
Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders
Yang S, Datta D, Elizabeth Woo, Duque A, Morozov YM, Arellano J, Slusher BS, Wang M, Arnsten AFT. Inhibition of glutamate-carboxypeptidase-II in dorsolateral prefrontal cortex: potential therapeutic target for neuroinflammatory cognitive disorders. Molecular Psychiatry 2022, 27: 4252-4263. PMID: 35732693, PMCID: PMC9718677, DOI: 10.1038/s41380-022-01656-x.Peer-Reviewed Original ResearchUnusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia
Arnsten AFT, Woo E, Yang S, Wang M, Datta D. Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia. Biological Psychiatry 2022, 92: 480-490. PMID: 35305820, PMCID: PMC9372235, DOI: 10.1016/j.biopsych.2022.02.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2021
M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance
Galvin VC, Yang S, Lowet AS, Datta D, Duque A, Arnsten AF, Wang M. M1 receptors interacting with NMDAR enhance delay-related neuronal firing and improve working memory performance. Current Research In Neurobiology 2021, 2: 100016. PMID: 35098156, PMCID: PMC8794314, DOI: 10.1016/j.crneur.2021.100016.Peer-Reviewed Original ResearchNMDAR Neurotransmission Needed for Persistent Neuronal Firing: Potential Roles in Mental Disorders
Yang S, Seo H, Wang M, Arnsten AFT. NMDAR Neurotransmission Needed for Persistent Neuronal Firing: Potential Roles in Mental Disorders. Frontiers In Psychiatry 2021, 12: 654322. PMID: 33897503, PMCID: PMC8064413, DOI: 10.3389/fpsyt.2021.654322.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAge‐related calcium dysregulation linked with tau pathology and impaired cognition in non‐human primates
Datta D, Leslie SN, Wang M, Morozov YM, Yang S, Mentone S, Zeiss C, Duque A, Rakic P, Horvath TL, van Dyck C, Nairn AC, Arnsten AFT. Age‐related calcium dysregulation linked with tau pathology and impaired cognition in non‐human primates. Alzheimer's & Dementia 2021, 17: 920-932. PMID: 33829643, PMCID: PMC8195842, DOI: 10.1002/alz.12325.Peer-Reviewed Original Research
2017
mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions
Jin L, Wang M, Yang S, Yang Y, Galvin V, Lightbourne T, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas C, Arnsten A. mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. Molecular Psychiatry 2017, 22: 1511-1511. DOI: 10.1038/mp.2017.206.Peer-Reviewed Original Research