SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro
Reddy VM, Dubuisson T, Einck L, Wallis RS, Jakubiec W, Ladukto L, Campbell S, Nacy CA. SQ109 and PNU-100480 interact to kill Mycobacterium tuberculosis in vitro. Journal Of Antimicrobial Chemotherapy 2012, 67: 1163-1166. PMID: 22258923, DOI: 10.1093/jac/dkr589.Peer-Reviewed Original ResearchConceptsPNU-100480Whole blood culturesMycobacterium tuberculosisRate of killingBlood culturesOrder of efficacyChequerboard titrationIndividual drugsIntracellular M. tuberculosisIntracellular Mycobacterium tuberculosisTime-kill studiesTwo-drug interactionsIntracellular activityMtb killingJ774A.1 mouse macrophagesSQ109M. tuberculosisMajor metaboliteTuberculosisMouse macrophagesBactericidal activityDrugsEfficacyKillingMacrophages