2023
1901. High Prevalence of Latent Tuberculosis Infection in a Malaysian Prison
Zhang L, Shenoi S, Kamarulzaman A, Dhaliwal S, Ahmad A, Altice F. 1901. High Prevalence of Latent Tuberculosis Infection in a Malaysian Prison. Open Forum Infectious Diseases 2023, 10: ofad500.1729. PMCID: PMC10677608, DOI: 10.1093/ofid/ofad500.1729.Peer-Reviewed Original ResearchLatent tuberculosis infectionPrevalence of LTBIRisk of LTBITB preventive therapyIndependent risk factorTuberculin skin testC-reactive proteinActive TBPreventive therapyTuberculosis infectionRisk factorsHigh prevalenceMultivariable logistic regressionOpioid use disorderRisk of hepatotoxicityChest X-rayDrug use historyPaucity of dataLTBI treatmentHCV infectionHepatitis CHepatitis BMedian ageBlood testsSkin testCommunity health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa
Norton S, Moll A, Madi J, Nkomo N, Brooks R, Andrews L, Shenoi S. Community health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa. African Journal Of AIDS Research 2023, 22: 131-135. PMID: 37337826, DOI: 10.2989/16085906.2023.2213213.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyCommunity health workersLargest HIV epidemicCause of deathNon-communicable diseasesHealth workersPreventive therapyRural resource-limited settingsHigh TB incidence ratesFurther implementation researchTB incidence rateRate of referralResource-limited settingsMedian ageTreatment initiationHIV epidemicIncidence rateRural South AfricaHIVInfectious diseasesTuberculosisImplementation researchScreening resultsDiseasePatients
2022
Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients
Ortigoza MB, Yoon H, Goldfeld KS, Troxel AB, Daily JP, Wu Y, Li Y, Wu D, Cobb GF, Baptiste G, O’Keeffe M, Corpuz MO, Ostrosky-Zeichner L, Amin A, Zacharioudakis IM, Jayaweera DT, Wu Y, Philley JV, Devine MS, Desruisseaux MS, Santin AD, Anjan S, Mathew R, Patel B, Nigo M, Upadhyay R, Kupferman T, Dentino AN, Nanchal R, Merlo CA, Hager DN, Chandran K, Lai JR, Rivera J, Bikash CR, Lasso G, Hilbert TP, Paroder M, Asencio AA, Liu M, Petkova E, Bragat A, Shaker R, McPherson DD, Sacco RL, Keller MJ, Grudzen CR, Hochman JS, Pirofski LA, Rahman F, Ajayi A, Rodriguez S, Ledesma A, Keeling D, Rappoport N, Ebel S, Kim J, Chang M, Chan K, Patel P, Martocci A, Dave S, Darwish Y, Taveras M, Shoyelu V, Xin P, Iturrate E, Moldolsky L, Raimondo B, Mendez S, Hughes P, Sterling S, Lord A, Yaghi S, Veloso K, Sheikh M, Visconti-Ferrara E, Fleming A, Youn H, Jane Fran B, Medina R, McKell R, Khan S, Hamilton T, Sanchez C, Patel N, Cleare L, Vergnolle O, Nakouzi A, Quevedo G, Bortz R, Wirchnianski A, Florez C, Babb R, Ayala J, Tsagaris K, James A, Eke I, Obeidallah A, Sandu O, Sohval S, Serrano-Rahman L, Uehlinger J, Bartash R, Al-Abduladheem A, Gendlina I, Sheridan C, Bortnick A, Eichler J, Kaufman R, Yukelis S, Pennock M, Goggin M, Shen C, Annam J, Khokhar A, Barboto D, Lally B, Lee A, Lee M, Yang X, Allen S, Malaviya A, Moussa O, Park R, Sample R, Bae A, Benoni G, Boerger L, Baker L, Luther M, Ameti L, Briggs N, Golden M, Gormally M, Huang G, Johnson R, Morrison A, Montagna-Hill M, Rivera B, Cortezzo G, Debski K, Nicoletti, DeBenedictis K, Davis R, Marshall C, Duque Cuartas M, Beauchamps L, Bertran-Lopez J, Gonzales Zamora J, Delgado-Lelievre M, Dominguez S, Lee C, Kusack H, Karakeshishyan V, Hajaz A, Deniz D, Garcia G, Dae K, Blenet P, Jaffe D, Olson L, Sabogal D, Blust O, Del Prete Perez V, Bornia C, Rodriguez-Perez V, Calderon V, Ramdev R, Jolly A, Guzman I, Guerra R, Brito S, Hobbs R, Denham R, Dick J, Hernandez M, Nielsen L, Anjum S, Mader S, Stutz T, Mammadova M, Nichols P, Khan T, Boktour M, Castaneda B, Benitez B, Hinojosa E, Guerra B, Ortiz A, Hebbeler-Clark R, McShane P, Hibbard R, Hawkins B, Dohanich E, Wadle C, Greenlee K, Brooks J, Herrick C, Gode A, Bergl P, Hu K, Patel J, Srinivasan S, Graf J, Klis C, Reimer K, Carpenter E, Naczek C, Petersen R, Dex R, Drossart J, Zelten J, Brummitt C, Liang M, Yanny L, Dennison G, Runningen P, Brzezinski B, Fiebig S, Naczek C, Kasdorf M, Parameswaran L, Corcoran A, Rohatgi A, Wronska M, Wu X, Srinivasan R, Deng F, Filardo T, Pendse J, Blaser S, Whyte O, Gallagher J, Thomas O, Ramos D, Sturm-Reganato C, Fong C, Daus I, Payoen A, Chiofolo J, Friedman M, Wu D, Jacobson J, Schneider J, Sarwar U, Wang H, Huebinger R, Dronavalli G, Bai Y, Grimes C, Eldin K, Umana V, Martin J, Heath T, Bello F, Ransford D, Laurent-Rolle M, Shenoi S, Akide-Ndunge O, Thapa B, Peterson J, Knauf K, Patel S, Cheney L, Tormey C, Hendrickson J. Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients. JAMA Internal Medicine 2022, 182: 115-126. PMID: 34901997, PMCID: PMC8669605, DOI: 10.1001/jamainternmed.2021.6850.Peer-Reviewed Original ResearchConceptsCCP recipientsPlacebo recipientsSecondary outcomesSymptom durationHospitalized patientsPrimary outcomeDay 28COVID-19SARS-CoV-2 serostatusSARS-CoV-2 titersWorld Health Organization (WHO) ordinal scaleCOVID-19 convalescent plasmaConvalescent plasma usePlacebo-controlled trialLess daysExploratory subgroup analysisNon-Hispanic blacksSARS-CoV-2CCP efficacyConcomitant medicationsAdverse eventsClinical improvementSymptom onsetConvalescent plasmaMedian age
2021
Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa
Ahmed AA, Grammatico M, Moll AP, Malinga S, Makhunga P, Charalambous S, Ladines-Lim JB, Jones J, Choi K, Shenoi SV. Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa. Global Health Action 2021, 14: 1979281. PMID: 34652990, PMCID: PMC8525921, DOI: 10.1080/16549716.2021.1979281.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyHealth care workersPrimary healthcare clinicsLower prescription ratesPrescription ratesRural South AfricaCare workersIsoniazid preventative therapyIncidence of tuberculosisCross-sectional studyGovernment district hospitalsPreventive therapyMedian ageMultivariable analysisPreventative therapyDistrict hospitalHealthcare clinicsHCW trainingPatient disclosureTPT useConsolidated FrameworkLogistic regressionImplementation researchSelf-reported dataPrescribers
2020
989. Pre-exposure Prophylaxis (PrEP) Short-Term Retention Among Heavy Alcohol Users in Rural South Africa
Grammatico M, Choi K, Moll A, Shenoi S. 989. Pre-exposure Prophylaxis (PrEP) Short-Term Retention Among Heavy Alcohol Users in Rural South Africa. Open Forum Infectious Diseases 2020, 7: s523-s523. PMCID: PMC7776627, DOI: 10.1093/ofid/ofaa439.1175.Peer-Reviewed Original ResearchAlcohol use disorderHazardous alcohol usePrEP deliveryCommunity-based modelAntiretroviral therapyHIV testingAlcohol usersYoung menSexual partnersAlcohol usePre-exposure prophylaxisHazardous alcohol usersInconsistent condom useDifferentiated service deliveryOne-month followHome addressParticipant's home addressHeavy alcohol usersPrEP initiatorsPill countMedian ageHIV servicesEligible participantsHIV preventionPrevention services1656. Factors associated with low TB preventative therapy prescription rates among healthcare workers in rural South Africa
Ahmed A, Grammatico M, Malinga S, Makhunga P, Moll A, Ladines-Lim J, Jones J, Choi K, Shenoi S. 1656. Factors associated with low TB preventative therapy prescription rates among healthcare workers in rural South Africa. Open Forum Infectious Diseases 2020, 7: s816-s817. PMCID: PMC7778258, DOI: 10.1093/ofid/ofaa439.1834.Peer-Reviewed Original ResearchPrimary care clinicsLower prescription ratesPrescription ratesHealthcare workersPatients' nondisclosureRural South AfricaConclusions Healthcare workersIsoniazid preventive therapyProfessional nursesRural district hospitalMedical officersCross-sectional surveyEligible patientsMortality benefitPreventive therapyMedian ageCare clinicsPreventative therapyTuberculosis incidenceDistrict hospitalSelf-reported knowledgePatientsHCW trainingMultivariate analysisPrescribers759. Where can we find active TB? Case finding at community sites and alcohol based venues (ABVs) in rural South Africa
Choi K, Shenoi S, Moll A, Friedland G. 759. Where can we find active TB? Case finding at community sites and alcohol based venues (ABVs) in rural South Africa. Open Forum Infectious Diseases 2020, 7: s426-s426. PMCID: PMC7778049, DOI: 10.1093/ofid/ofaa439.949.Peer-Reviewed Original ResearchAlcohol Use Disorders Identification TestHazardous alcohol useActive TBTB casesAlcohol useCase detectionOlder ageMean AUDITActive TB diseaseUseful adjunctive strategyPrimary care clinicsHIV rapid testsCommunity health workersTuberculosis case detectionResource limited settingsCases of TBDisorders Identification TestSubstance abuse servicesTB diseaseRandom glucoseBlood pressureMedian ageCare clinicsAdjunctive strategiesRisk factors764. Correlates of Lost to Follow-up Among Newly Diagnosed Older People with HIV in Ukraine
Allen A, Zeziulin O, Postnov O, Rozanova J, Litz T, Zaviryukha I, Kiriazova T, Shenoi S. 764. Correlates of Lost to Follow-up Among Newly Diagnosed Older People with HIV in Ukraine. Open Forum Infectious Diseases 2020, 7: s427-s428. PMCID: PMC7777685, DOI: 10.1093/ofid/ofaa439.954.Peer-Reviewed Original ResearchHIV clinicSecond largest HIV epidemicMethods Retrospective chart reviewOlder peopleRetrospective chart reviewTime of diagnosisAdjusted odds ratioLargest HIV epidemicMultivariate logistic regressionHIV service deliveryResource-limited settingsCorrelates of lossHIV careART prescriptionChart reviewClinical characteristicsYounger patientsHIV outcomesMedian agePoor outcomeHIV epidemicOdds ratioFirst appointmentLTFUHIV
2019
1657. Notes From the Field: A Survey of Mobile Device Usage Among Individuals in KwaZulu-Natal, South Africa
Campbell B, Choi K, Gray M, Canan C, Moll A, Dillingham R, Shenoi S. 1657. Notes From the Field: A Survey of Mobile Device Usage Among Individuals in KwaZulu-Natal, South Africa. Open Forum Infectious Diseases 2019, 6: s606-s606. PMCID: PMC6810393, DOI: 10.1093/ofid/ofz360.1521.Peer-Reviewed Original ResearchMHealth interventionsRural KwaZulu-NatalCondomless sexHealthcare messagesCare of HIVLack of circumcisionMultivariable logistic regressionMedical male circumcisionMonthly grantsCircumcision statusMedian ageHIV counselingMiddle-income countriesLMIC populationsMale circumcisionCondom useCommunity settingsKwaZulu-NatalLogistic regressionYoung womenHealthcare interventionsHIVUnderserved populationsHealth information seekingHealth information1673. Gendered Patterns of HIV, TB, and Other Primary Care Referrals in Rural South Africa
Choi K, Moll A, Shenoi S. 1673. Gendered Patterns of HIV, TB, and Other Primary Care Referrals in Rural South Africa. Open Forum Infectious Diseases 2019, 6: s612-s613. PMCID: PMC6809581, DOI: 10.1093/ofid/ofz360.1537.Peer-Reviewed Original ResearchPrimary care servicesRural South AfricaHazardous drinkingPositive screeningHealth concernIsoniazid preventive therapyLast clinic visitPrimary care referralsMultivariable logistic regressionHealth careCommunity health workersHealth-seeking behaviourCommunity-based servicesCare referralClinic visitsPreventive therapyMedian ageClinical outcomesSaharan AfricaHealthcare useHealth workersHIV effortsMore referralsCare servicesHIV
2017
Community Health Workers Can Strengthen Isoniazid Preventive Therapy Implementation in Rural KwaZulu-Natal, South Africa
Norton S, Moll A, Madi J, Nkomo N, Brooks R, Shenoi S. Community Health Workers Can Strengthen Isoniazid Preventive Therapy Implementation in Rural KwaZulu-Natal, South Africa. Open Forum Infectious Diseases 2017, 4: s119-s119. PMCID: PMC5632264, DOI: 10.1093/ofid/ofx163.146.Peer-Reviewed Original ResearchIsoniazid preventive therapyCommunity health workersRural KwaZulu-NatalHealth workersHigh TB incidence ratesDifferentiated care modelProportion of patientsHIV treatment programsTB incidence rateCause of deathResource limited settingsIPT initiationPreventive therapySecondary outcomesTB casesMedian agePrimary outcomeTB epidemicPreventive treatmentChronic diseasesIncidence rateSymptom screenCHW rolesCare modelTherapy implementation
2015
What motivates use of community-based human immunodeficiency virus testing in rural South Africa?
Upadhya D, Moll AP, Brooks RP, Friedland G, Shenoi SV. What motivates use of community-based human immunodeficiency virus testing in rural South Africa? International Journal Of STD & AIDS 2015, 27: 662-671. PMID: 26134323, PMCID: PMC4851612, DOI: 10.1177/0956462415592789.Peer-Reviewed Original ResearchConceptsHIV testingRural South AfricaRural resource-limited settingsHuman immunodeficiency virus (HIV) testingCommunity-based HIVCommunity-based testingMedian CD4 countRecent HIV exposureCommunity-based HIV testing programmeFirst-time testersHIV testing programsVoluntary HIV testingResource-limited settingsCD4 countHIV exposureMedian ageHIV statusVirus testingCommunity testingHIVCells/Rural settingsFamily membersSix-itemRisky lifestyles
2014
Active case finding for tuberculosis among people who inject drugs on methadone treatment in Dar es Salaam, Tanzania
Gupta A, Mbwambo J, Mteza I, Shenoi S, Lambdin B, Nyandindi C, Doula BI, Mfaume S, Bruce RD. Active case finding for tuberculosis among people who inject drugs on methadone treatment in Dar es Salaam, Tanzania. The International Journal Of Tuberculosis And Lung Disease 2014, 18: 793-798. PMID: 24902554, PMCID: PMC4506927, DOI: 10.5588/ijtld.13.0208.Peer-Reviewed Original ResearchConceptsWorld Health OrganizationActive casesTB prevalenceCase findingMore TB symptomsNew TB casesSymptom-based questionnaireActive case findingPopulation of PWIDTuberculosis case detectionHigh occupational riskTB symptomsTB casesMedian ageTB controlMethadone treatmentHuman immunodeficiencyMethadone clientsCase detectionOccupational riskPrevalenceHealth OrganizationDar es SalaamPWIDDrugs