2021
Combinatorial actions of glucocorticoid and mineralocorticoid stress hormone receptors are required for preventing neurodegeneration of the mouse hippocampus
Oakley R, Whirledge S, Petrillo M, Riddick N, Xu X, Moy S, Cidlowski J. Combinatorial actions of glucocorticoid and mineralocorticoid stress hormone receptors are required for preventing neurodegeneration of the mouse hippocampus. Neurobiology Of Stress 2021, 15: 100369. PMID: 34368410, PMCID: PMC8326231, DOI: 10.1016/j.ynstr.2021.100369.Peer-Reviewed Original ResearchDentate gyrus neuronsMineralocorticoid receptorGyrus neuronsKnockout miceSingle knockout counterpartsConditioned fear testDouble knockout miceStress hormone receptorsPrimary stress hormoneCA2 neuronsHippocampal glucocorticoidRelated nuclear receptorsKnockout counterpartsNeuronal deathDentate gyrusNeuronal markersLarge cohortMouse hippocampusPsychiatric disordersGlucocorticoidsHippocampusCell proliferation pathwaysChronic stressStress hormonesProfound neurodegeneration
2019
SAT-005 Gene Expression and Behavioral Alterations in Mice with Conditional Knockout of GR, MR, or Both GR and MR in the Hippocampus
Oakley R, Whirledge S, Riddick N, Quinn M, Xu X, Moy S, Cidlowski J. SAT-005 Gene Expression and Behavioral Alterations in Mice with Conditional Knockout of GR, MR, or Both GR and MR in the Hippocampus. Journal Of The Endocrine Society 2019, 3: sat-005. PMCID: PMC6552087, DOI: 10.1210/js.2019-sat-005.Peer-Reviewed Original ResearchMineralocorticoid receptorDouble knockout miceGlucocorticoid receptorGRKO miceKnockout miceEmx1-Cre miceRelated mineralocorticoid receptorDepression-like behaviorHippocampal glucocorticoid receptorsConditioned fear testOpen field testMonths of agePrimary stress hormoneSwim testPsychiatric disordersUnique signaling pathwaysBehavioral alterationsBody weightCognitive impairmentHippocampusGlucocorticoidsMutant miceStress hormonesBrain functionMice
2015
Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization
Whirledge SD, Oakley RH, Myers PH, Lydon JP, DeMayo F, Cidlowski JA. Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 15166-15171. PMID: 26598666, PMCID: PMC4679013, DOI: 10.1073/pnas.1508056112.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorPresence of GRExaggerated inflammatory responseSex steroid receptorsImmune cell recruitmentStromal cell decidualizationFemale reproductive tractAdrenal axisKO miceInflammatory responseUterine physiologyUterine biologyEndocrine organMouse uterusBlastocyst implantationGlucocorticoid signalingMouse modelCell recruitmentEmbryo implantationImmunomodulatory functionsKnockout miceGR signalingSteroid receptorsReproductive tractDecidualization