A microRNA regulating adult hematopoietic stem cells
Guo S, Scadden DT. A microRNA regulating adult hematopoietic stem cells. Cell Cycle 2010, 9: 3637-3638. PMID: 20855952, DOI: 10.4161/cc.9.18.13174.Peer-Reviewed Original ResearchMicroRNA miR-125a controls hematopoietic stem cell number
Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT. MicroRNA miR-125a controls hematopoietic stem cell number. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 14229-14234. PMID: 20616003, PMCID: PMC2922532, DOI: 10.1073/pnas.0913574107.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsStem cell pool sizeStem cell stateLong-term hematopoietic stem cellsCell-autonomous mannerStem cellsStem cell populationCell pool sizeMiR-125aStem cell numbersHematopoietic stem cell numbersEnzyme DicerImmature hematopoietic progenitorsHematopoietic differentiationMutant animalsCell statesProgenitor cell apoptosisMicroRNA processing enzyme DicerMicroRNA clusterProapoptotic genesHSPC populationsHematopoietic expansionSpecific microRNAsUnique microRNAsHSPC apoptosisBone progenitor dysfunction induces myelodysplasia and secondary leukaemia
Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010, 464: 852-857. PMID: 20305640, PMCID: PMC3422863, DOI: 10.1038/nature08851.Peer-Reviewed Original ResearchConceptsSpecific mesenchymal cellsMesenchymal cellsHuman bone marrow failureDeletion of Dicer1Osteolineage cellsTissue homeostasisHeterologous cellsDicer1 deletionGene expressionMature osteoblastsRegulatory nicheBone marrow failureDiamond syndromeMesenchymal subsetsStem cellsOsteoprogenitorsReduced expressionDeletionSecondary neoplastic diseaseStromal cellsMarrow failureDICER1CellsHaematopoiesisGenetic abnormalities