Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter
Eastman AE, Chen X, Hu X, Hartman AA, Morales A, Yang C, Lu J, Kueh HY, Guo S. Resolving Cell Cycle Speed in One Snapshot with a Live-Cell Fluorescent Reporter. Cell Reports 2020, 31: 107804. PMID: 32579930, PMCID: PMC7418154, DOI: 10.1016/j.celrep.2020.107804.Peer-Reviewed Original ResearchConceptsFluorescent reportersLive-cell fluorescent reporterCell cycle speedFluorescent timer proteinsCell proliferationCell cycle dynamicsRed fluorescent proteinFaster cycling cellsFate transitionsFusion reporterActive lociTimer proteinFluorescent proteinLength heterogeneityComplex tissuesHematopoietic cellsCycling cellsReporterFluorescence ratioCycle dynamicsProteinFunctional heterogeneityMouse strainsSolid tissuesCycle speedYAP Non-cell-autonomously Promotes Pluripotency Induction in Mouse Cells
Hartman AA, Scalf SM, Zhang J, Hu X, Chen X, Eastman AE, Yang C, Guo S. YAP Non-cell-autonomously Promotes Pluripotency Induction in Mouse Cells. Stem Cell Reports 2020, 14: 730-743. PMID: 32243844, PMCID: PMC7160372, DOI: 10.1016/j.stemcr.2020.03.006.Peer-Reviewed Original ResearchConceptsPluripotency inductionCell typesMouse somatic cellsMultiple stem cell typesHeterologous cell typesStem cell typesPluripotent stem cellsEarly embryogenesisSomatic cellsDistinct functionsMouse cellsMatricellular proteinYAPRecombinant CYR61Stem cellsAutonomous roleCyr61Specific cellsBystander cellsProteinCellsInductionPluripotencyEmbryogenesisControl mechanisms