Novel Fluorescent Timer Tool Enables Characterization of Erythropoietic Differentiation Based on Differential Cell Cycling Speeds
Modepalli S, Eastman A, Shaw C, Guo S, Hattangadi S, Kupfer G. Novel Fluorescent Timer Tool Enables Characterization of Erythropoietic Differentiation Based on Differential Cell Cycling Speeds. Blood 2020, 136: 27-28. DOI: 10.1182/blood-2020-141666.Peer-Reviewed Original ResearchCell cycle speedCell divisionErythroid differentiationFusion proteinOrthochromatic erythroblastsLive-cell reporterStress erythropoiesisFluorescent timer proteinsAvailable proteomic dataSubsequent cell divisionRapid cell divisionUpregulation of genesCell cycle dynamicsErythroid cell proliferationSingle-cell levelRed fluorescent proteinFaster cycling cellsCell cycle behaviorFT proteinPhosphoproteomic investigationsDiscrete molecular targetsInducible promoterProteomic dataActive lociStress hematopoiesis